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Director Protein Engineering Jobs (NOW HIRING)

Merck & Co.

... Director to contribute to our Company's protein therapeutic efforts from discovery through to ... engineering, molecular biology, bioengineering, or related STEM field; Relevant experience that ...

Manifold Bio

Senior Director, Biotherapeutics

Boston, MA

$240K - $340K/yr

Our team of protein engineers, biologists, and computational scientists works across this full ... Manifold Bio is seeking an exceptional Senior Director of Biotherapeutics to help guide and mature ...

Grifols, S.A

Principal Scientist

San Carlos, CA · On-site

$165 - $205/hr

We are seeking an innovative and experienced Principal Scientist to direct protein engineering and molecular biology projects as a part of the Technology Development team. This team initiates and ...

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$73K

$194.7K

$254K

How much do director protein engineering jobs pay per year?

As of Aug 18, 2026, the average yearly pay for director protein engineering in the United States is $194,709.00, according to ZipRecruiter salary data. Most workers in this role earn between $141,500.00 and $253,000.00 per year, depending on experience, location, and employer.

What does a director protein engineering do?

A Director of Protein Engineering leads teams in designing, optimizing, and developing proteins for various applications, such as therapeutics, biotechnology, or industrial enzymes. They oversee research strategies, manage cross-functional collaborations, and ensure project goals align with company objectives. This role requires expertise in molecular biology, structural biology, and protein design, along with strong leadership and project management skills.

What are the key skills and qualifications needed to thrive in the director protein engineering position?

A Director Protein Engineering typically requires a PhD in biochemistry, molecular biology, or related fields, along with extensive experience in protein engineering, assay development, and team leadership. Familiarity with industry-standard tools like molecular modeling software, high-throughput screening systems, and relevant regulatory compliance certifications is important. Exceptional project management, communication, and strategic decision-making skills help in guiding cross-functional teams and driving innovation. These competencies ensure effective oversight of research programs, facilitate collaboration, and enable advanced problem-solving to achieve organizational goals.

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Director Protein Engineering jobs near you
Infographic showing various Director Protein Engineering job openings in the United States as of August 2026, with employment types broken down into 92% Full Time, 4% Part Time, 3% Contract, and 1% Nights. Highlights an 85% Physical, 5% Hybrid, and 10% Remote job distribution, with an average salary of $194,709 per year, or $93.6 per hour.

Scientist, Computational Protein Design

Adimab

Mountain View, CA • On-site

Full-time

Medical, Retirement

Re-posted 13 days ago

Job description

Role: Scientist, Computational Protein Design

Adimab is the leading technology provider for therapeutic antibody drug discovery, focusing solely on our partnerships without pursuing an internal product pipeline. Since 2009, we have partnered with over 140 pharmaceutical and biotechnology companies, generating more than 650 therapeutic programs, of which more than 85 have entered clinical trials.  

Role Overview 
The role is on Adimab's computational biology team in Mountain View, CA. Data-driven approaches have been central to the development of the Adimab platform, and the team is actively utilizing and developing modern de novo protein design and generative AI methods to extend its capabilities. You will serve as the computational lead for protein design campaigns, embedded within a world-class team of modeling and wet-bench scientists, with direct access to Adimab's industry-leading experimental capabilities to drive the design-build-test cycle.  

Responsibilities 

  • Take end-to-end ownership of computational protein design campaigns — from design generation through wet-lab collaboration, analysis of experimental data, and optimization of the design-build-test cycle. Applications span de novo epitope-targeted IgG, VHH, and minibinder design, as well as protein solubilization and stabilization. 
  • Partner with wet-lab teams to design experiments that generate custom training data for affinity, epitope, and specificity prediction models. Train and rigorously benchmark resulting models against internal and external baselines. 
  • Build and maintain the computational infrastructure supporting both protein design campaigns and model development, including reproducible pipelines and integration of computational outputs with wet-lab data. 
  • Track developments in computational protein design and ML; evaluate relevance to Adimab's platform and identify opportunities for integration. 
  • Serve as a resource for wet-lab scientists on AI/ML capabilities and best practices, helping antibody and protein engineering teams apply computational design methods. 

Needed Upon Hire 

  • PhD in Biophysics, Biochemistry, Structural Biology, Computational Biology, or a related field. 
  • 2–4 years of post-PhD experience specifically in computational protein or binder design. 
  • Strong foundation in the analysis of structural and energetic factors driving protein-protein interactions. 
  • Proficiency with structure prediction and generative design tools such as RFAntibody, BindCraft, and Protenix. Crystallography or cryo-EM experience is a plus. 
  • Strong Python skills and experience building reproducible analysis and modeling pipelines. 
  • Proven track record of publication or patent contribution in applied ML for proteins or computational design. 
Pay Range: $156,800 - $165,760 base salary and eligibility for 15% bonus

Come join us! 

Our integrated antibody discovery and engineering platform provides unprecedented speed from antigen to purified, full-length human IgGs with exquisite specificity and biophysical behavior. We offer fundamental advantages by delivering diverse panels of antibodies that meet the most demanding standards for affinity, epitope specificity, species cross-reactivity, and developability. We enable our partners to rapidly expand their biologics pipelines through a broad spectrum of technology access arrangements.

As a profitable privately-held biotech company, we take a long-term view on value creation and make substantial investments in technology development, research, and our people. We offer individually tailored compensation packages comprised of a competitive salary, meaningful equity, a 2:1 401(k) match, and comprehensive health care benefits.

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