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Protein Engineering Jobs in Maryland (NOW HIRING)

Axle

Scientist

Rockville, MD · On-site

With experts in biomedical science, software engineering, and program management, we focus on ... Work products and documents related to performing protein assays, phenotyping of mutant mouse ...

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Protein Engineering information

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$31.5K

$61.1K

$92.7K

How much do protein engineering jobs pay per year?

As of Sep 4, 2026, the average yearly pay for protein engineering in Maryland is $61,122.00, according to ZipRecruiter salary data. Most workers in this role earn between $45,600.00 and $69,900.00 per year, depending on experience, location, and employer.

What is protein engineering?

A Protein Engineering job involves designing, modifying, and optimizing proteins for specific applications in medicine, biotechnology, and industry. Scientists in this field use computational modeling, directed evolution, and genetic engineering to enhance protein functions. Roles may include developing enzymes for drug production, improving therapeutic proteins, or creating biomaterials. This work often requires expertise in molecular biology, biochemistry, and structural biology.

What are the typical daily responsibilities of someone working in protein engineering?

A typical day in Protein Engineering involves designing and conducting experiments to modify protein sequences, expressing and purifying proteins, and analyzing their structure or function using techniques like chromatography and spectroscopy. You will often document your results, troubleshoot unexpected findings, and present data to colleagues or project teams. Collaboration with scientists in molecular biology, bioinformatics, and structural biology is common to ensure robust experimental design and data interpretation. The role may also include literature reviews to stay updated with the latest research and participating in team meetings to plan next steps or project timelines.

What are the key skills and qualifications needed to thrive in protein engineering, and why are they important?

To thrive in Protein Engineering, you need a solid background in biochemistry, molecular biology, and genetic engineering, typically supported by a relevant advanced degree. Experience with laboratory techniques such as PCR, site-directed mutagenesis, protein expression/purification, and analytical tools like mass spectrometry or chromatography is essential. Strong problem-solving abilities, attention to detail, and effective teamwork and communication skills help you stand out in this role. These competencies are crucial for designing novel proteins, collaborating in multidisciplinary teams, and ensuring successful project outcomes in biotech or pharmaceutical environments.

How much do protein engineers make?

Protein engineers typically earn a median salary ranging from $70,000 to $120,000 annually, depending on experience, education, and location. Advanced skills in molecular biology, bioinformatics, and laboratory techniques can lead to higher compensation, especially in biotech or pharmaceutical industries.

What do protein engineers do?

Protein engineers design and modify proteins to improve their functions or create new ones, often using techniques like directed evolution and computational modeling. They work in research labs, utilizing tools such as gene editing and structural analysis to develop applications in medicine, agriculture, and industry.

What are the most commonly searched types of Protein Engineering jobs in Maryland?

The most popular types of Protein Engineering jobs in Maryland are:

What are popular job titles related to Protein Engineering jobs in Maryland?

For Protein Engineering jobs in Maryland, the most frequently searched job titles are:

What job categories do people searching Protein Engineering jobs in Maryland look for?

The top searched job categories for Protein Engineering jobs in Maryland are:

What cities in Maryland are hiring for Protein Engineering jobs?

Cities in Maryland with the most Protein Engineering job openings:

Protein Engineering jobs near you
Infographic showing various Protein Engineering job openings in Maryland as of August 2026, with employment types broken down into 94% Full Time, 3% Part Time, 2% Contract, and 1% Nights. Highlights an 86% Physical, 4% Hybrid, and 10% Remote job distribution, with an average salary of $61,122 per year, or $29.4 per hour.

Computational Protein Engineer

H. T. PROF Group

Rockville, MD • On-site

$140 - $210/hr

Other

Posted 7 hours ago

Posted today

Job description

Do you value scientific rigor, long-term relationships, and working alongside the best in the field?


My client offers scientists genuine latitude to pursue creative endeavors and true research.


My client seeks a Computational Protein Engineer to build and lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles.


The ideal candidate will take on the following responsibilities:
  • Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design
  • Drive protein expression, purification, and characterization workflows across multiple formats
  • Design and execute binding and functional assays to evaluate and iterate on engineered proteins
  • Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
  • Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies

The ideal candidate will possess the following qualifications:
  • PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience
  • Hands-on expertise in protein expression, purification, and characterization
  • Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
  • Peer-reviewed publications and/or patents in antibody or protein engineering
  • Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
  • Proven ability to lead technical teams and manage complex, multi-faceted projects
  • Outstanding written and verbal communication skills
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