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How much do protein engineering jobs pay per year?

As of Jul 26, 2026, the average yearly pay for protein engineering in the United States is $62,977.00, according to ZipRecruiter salary data. Most workers in this role earn between $47,000.00 and $72,000.00 per year, depending on experience, location, and employer.

What is a Protein Engineering job?

A Protein Engineering job involves designing, modifying, and optimizing proteins for specific applications in medicine, biotechnology, and industry. Scientists in this field use computational modeling, directed evolution, and genetic engineering to enhance protein functions. Roles may include developing enzymes for drug production, improving therapeutic proteins, or creating biomaterials. This work often requires expertise in molecular biology, biochemistry, and structural biology.

What are the key skills and qualifications needed to thrive in the Protein Engineering position, and why are they important?

To thrive in Protein Engineering, you need a solid background in biochemistry, molecular biology, and genetic engineering, typically supported by a relevant advanced degree. Experience with laboratory techniques such as PCR, site-directed mutagenesis, protein expression/purification, and analytical tools like mass spectrometry or chromatography is essential. Strong problem-solving abilities, attention to detail, and effective teamwork and communication skills help you stand out in this role. These competencies are crucial for designing novel proteins, collaborating in multidisciplinary teams, and ensuring successful project outcomes in biotech or pharmaceutical environments.

What are typical daily responsibilities for someone working in Protein Engineering?

A typical day in Protein Engineering involves designing and conducting experiments to modify protein sequences, expressing and purifying proteins, and analyzing their structure or function using techniques like chromatography and spectroscopy. You will often document your results, troubleshoot unexpected findings, and present data to colleagues or project teams. Collaboration with scientists in molecular biology, bioinformatics, and structural biology is common to ensure robust experimental design and data interpretation. The role may also include literature reviews to stay updated with the latest research and participating in team meetings to plan next steps or project timelines.

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What cities are hiring for Protein Engineering jobs? Cities with the most Protein Engineering job openings:
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Protein Engineering jobs near you
Infographic showing various Protein Engineering job openings in the United States as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $62,977 per year, or $30.3 per hour.
Scientist II, Protein Expression and Purification

Scientist II, Protein Expression and Purification

Foresite Labs

San Diego, CA • On-site

$110K - $120K/yr

Full-time

Posted 9 days ago

Job description

Scientist II, Protein Expression and Purification
Location: San Diego, CA
Job Type: Full-Time
Compensation: $110,000 to $120,000
About Us
We are a venture-backed, stealth-stage biotechnology company based in San Diego, focused on developing novel technologies that will redefine how disease is detected, characterized, and managed with a novel approach to clinical genomics. Our mission is to fundamentally transform healthcare through a convergence of innovation across multiple scientific disciplines.
Founded by industry veterans with decades of experience in life sciences tools and diagnostics, our leadership team brings a proven track record of translating scientific insight into successful commercial products. Our investors include some of the most respected names in healthcare and deep tech.
Position Overview
We are seeking a Scientist II, Enzyme Assay & Characterization to play a key role in developing and executing biochemical assays that support the company's multi-omics platform development. This individual will optimize and implement assays.
The Scientist II will contribute directly to enzyme evaluation. This role offers opportunities for broad technical growth, including assay development, molecular biology, protein engineering and integration.
The candidate must be detail-oriented, analytical, and collaborative, thriving in a dynamic environment that values innovation, cross-disciplinary interaction, and scientific rigor.
Key Responsibilities
• Clone, express, and screen protein constructs in bacterial expression systems.
• Optimize bacterial expression conditions.
• Execute purification workflows.
• Characterize protein quality.
• Optimize and implement biochemical assays.
• Develop, optimize, and validate spectroscopic and fluorescence-based assays.
• Troubleshoot and refine assays for reproducibility, sensitivity, and throughput.
• Collaborate closely with protein expression/purification, enzymology, protein engineering, and molecular biology teams.
• Document methods, maintain rigorous records, contribute to SOPs and prepare data summaries and reports.
• Support lab organization, maintain equipment, and ensure compliance with safety and reproducibility practices.
Qualifications
Required
• B.S. in Biochemistry, Molecular Biology, Enzymology, or related field with 4-6 years
of relevant experience, OR M.S. with 2-4 years of relevant experience.
• Demonstrated experience optimizing and implementing biochemical assays.
• Hands-on experience with spectroscopic and fluorescence-based assays.
• Hands-on experience with gel electrophoresis and gel-based assays.
• Strong experience with data visualization software.
• Excellent organizational, problem-solving, and communication skills.
• Ability to work independently and collaboratively in cross-functional teams.
Why Join Us
• Influence the foundational technologies and strategies of a company poised to shape the future of clinical genomics and healthcare.
• Work in a dynamic, collaborative environment where innovation and scientific rigor are deeply valued.
• Join a seasoned and multidisciplinary team tackling high-impact problems at the intersection of science and engineering.
• Competitive compensation and equity package, comprehensive benefits, and flexibility to support work-life integration.
We are an equal opportunity employer. We thrive on diversity and collaboration.

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