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Downstream Protein Purification Phd Jobs (NOW HIRING)

Responsibilities include chromatography-based purification, recombinant protein QC related tasks ... Execute established downstream workflows to meet project specifications and client requirements.

Research Technician

Pasadena, CA · On-site

$19 - $25.75/hr

Harvest cells and assist with downstream, protein purification (modern chromatography methods). * Perform immunofluorescence microscopy to assess protein localization. * Conduct SDS-PAGE gel analysis ...

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Downstream Protein Purification Phd information

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How much do downstream protein purification phd jobs pay per hour?

As of Aug 14, 2026, the average hourly pay for downstream protein purification phd in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a downstream protein purification PhD?

To thrive as a Downstream Protein Purification PhD, you need an advanced understanding of protein chemistry, chromatography, and bioprocess engineering, typically supported by a PhD in biochemistry, biotechnology, or a related field. Familiarity with purification systems (such as AKTA), analytical tools (like HPLC), and regulatory standards (cGMP) is crucial. Strong problem-solving, attention to detail, and effective communication help drive process optimization and successful collaboration with multidisciplinary teams. These skills ensure robust, scalable purification processes that meet quality and regulatory requirements in biopharmaceutical production.

What is the difference between Downstream Protein Purification Phd vs Downstream Processing Scientist?

AspectDownstream Protein Purification PhdDownstream Processing Scientist
Required CredentialsPhD in Biochemistry, Molecular Biology, or related fieldBachelor's or Master's in Life Sciences or Chemical Engineering
Work EnvironmentResearch labs, biotech, pharmaceutical companiesManufacturing facilities, biotech, pharma industries
Employer & Industry UsageAcademic research, biotech R&D, pharmaceutical developmentProduction, process development, quality control

While both roles involve working with bioprocesses, a Downstream Protein Purification Phd typically focuses on advanced research and development of purification techniques, often in academic or R&D settings. In contrast, a Downstream Processing Scientist usually works in manufacturing environments, applying established protocols to produce and purify biotherapeutics at scale. The Phd role emphasizes innovation and experimental design, whereas the scientist role centers on process optimization and production efficiency.

What is a downstream protein purification PhD?

A Downstream Protein Purification PhD refers to an individual who has earned a doctoral degree specializing in the purification of proteins after they have been expressed in a host organism, typically as part of biopharmaceutical production. Downstream protein purification focuses on isolating, purifying, and characterizing target proteins from complex mixtures using various biochemical and biophysical methods. Professionals in this field are experts in techniques like chromatography, filtration, and centrifugation, ensuring the final product meets purity and quality standards required for research or therapeutic use.

What are some common challenges faced in a downstream protein purification PhD role and how can they be addressed?

One common challenge in a Downstream Protein Purification PhD role is optimizing purification protocols for novel or complex proteins, which often requires troubleshooting issues like low yield, aggregation, or impurities. Addressing these challenges typically involves iterative experimentation, staying updated on emerging purification technologies, and collaborating closely with upstream teams and analytical scientists. Additionally, balancing project timelines with the need for thorough documentation and compliance with regulatory standards is essential. Being proactive in cross-functional communication and leveraging automation or high-throughput techniques can also help streamline workflows and improve outcomes.
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Infographic showing various Downstream Protein Purification Phd job openings in the United States as of August 2026, with employment types broken down into 65% Full Time, and 35% Contract. Highlights an 100% In-person job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

Process Development Scientist I **30-33/HR

Actalent

Saint Louis, MO

$30 - $33/hr

Contractor

Medical, Dental, Vision, Life, Retirement, PTO

Posted 6 days ago


Job description

Process Development Scientist I (Downstream)

Job Description

This role offers the opportunity to join a dedicated team of Process Development Scientists focused on downstream protein purification. You will contribute to the development, confirmation, and transfer of downstream purification processes that support biopharmaceutical manufacturing. Working closely with customers, scientists, and cross-functional departments, you will help implement advanced solutions in high-quality biopharmaceutical facilities and play a key role in global operations.

Responsibilities

  • Perform laboratory experiments to develop, assess, and transfer downstream protein purification processes for use in manufacturing.
  • Operate and optimize industry-standard technologies such as chromatography, filtration, and ultrafiltration/diafiltration (UF/DF) in support of process development.
  • Learn to interpret client documents, process descriptions, and scientific literature to design effective strategies for process development and transfer activities.
  • Generate, analyze, and document experimental data with high attention to detail and adherence to standard procedures.
  • Communicate experimental findings, data interpretations, and process recommendations to a multidisciplinary team including upstream, downstream, and analytical scientists, quality assurance, process engineers, and customers.
  • Collaborate with cross-functional colleagues to ensure smooth transfer of developed processes into manufacturing environments.
  • Prioritize tasks effectively in a dynamic setting while maintaining compliance with established laboratory practices and safety guidelines.
  • Continuously expand technical knowledge and laboratory skills to support evolving project and organizational needs.

Essential Skills

  • Bachelor or Master of Science degree in Biology, Chemistry, Biochemistry, Chemical Engineering, or a related scientific field.
  • 1–2 years of relevant laboratory experience, preferably in protein purification or related bioprocessing.
  • Hands-on experience with protein purification techniques, including chromatography.
  • Fundamental understanding of biochemistry and its application to downstream process development.
  • Ability to function effectively in a constantly evolving environment and adapt to changing project needs.
  • High attention to detail with a strong commitment to following standard procedures and documentation practices.
  • Ability to work independently while managing multiple tasks and priorities.
  • Strong communication skills, including the ability to clearly present data and conclusions to technical and cross-functional audiences.
  • Physical ability to stand for extended periods, lift materials as required for laboratory work, and perform repetitive hand motions.

Additional Skills & Qualifications

  • Strong desire and demonstrated willingness to learn new laboratory techniques and technologies.
  • Interest in working with industry-standard downstream technologies such as chromatography, filtration, and UF/DF.
  • Ability to collaborate effectively with upstream, downstream, analytical, quality, and engineering teams.
  • Solid organizational and time-management skills to support multiple ongoing experiments and projects.

Work Environment

This position is based in a laboratory environment supporting biopharmaceutical process development. You will work hands-on with downstream processing equipment such as chromatography systems, filtration units, and UF/DF setups. The role requires standing for extended periods, performing repetitive hand motions, and occasionally lifting laboratory materials or equipment. The standard work schedule is Monday through Friday, approximately 9:00 a.m. to 5:00 p.m., with expectations to follow established safety procedures and laboratory best practices in a collaborative, fast-evolving setting

Job Type & Location

This is a Contract to Hire position based out of Saint Louis, MO.

Pay and Benefits

The pay range for this position is $30.00 - $33.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: • Medical, dental & vision • Critical Illness, Accident, and Hospital • 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available • Life Insurance (Voluntary Life & AD&D for the employee and dependents) • Short and long-term disability • Health Spending Account (HSA) • Transportation benefits • Employee Assistance Program • Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in Saint Louis,MO.

Application Deadline

This position is anticipated to close on Aug 13, 2026.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 20,000 consultants and 5,000 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500. We are proud to be an Engineering News-Record (ENR) Top 500 Design Firm for our engineering design services and a ClearlyRated Best of Staffing® winner for both client and talent service.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.

San Francisco Fair Chance Ordinance: Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI): We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.


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About Actalent

Sourced by ZipRecruiter

Actalent connects passion with purpose. Our scalable talent solutions and services capabilities drive value and results and provide the expertise to help our customers achieve more. Every day, our experts around the globe are making an impact. We're supporting critical initiatives in engineering and sciences that advance how companies serve the world. Actalent promotes consultant care and engagement through experiences that enable continuous development. Our people are the difference. Actalent is an operating company of Allegis Group, the global leader in talent solutions.

Company size

5,001 - 10,000 Employees

Headquarters location

Hanover, MD, US

Year founded

1983

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