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Downstream Protein Purification Phd Jobs (NOW HIRING)

Actalent

Scientist II, Protein Modification

Carlsbad, CA · On-site

$30 - $40/hr

This role focuses on downstream protein purification activities, including chromatography, tangential flow filtration (TFF), buffer preparation, analytical testing, and manufacturing documentation.

SIGNOBIO INC

Downstream Associate

Houston, TX · On-site

Responsibilities include chromatography-based purification, recombinant protein QC related tasks ... Execute established downstream workflows to meet project specifications and client requirements.

Zealand Pharma

$75 - $125/hr

PhD preferred (Scientist)* 1-2 years of relevant experience in protein purification and/or analytical chemistry (Associate Scientist); 2-3 years of relevant industry experience preferred (Scientist ...

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How much do downstream protein purification phd jobs pay per hour?

As of Aug 29, 2026, the average hourly pay for downstream protein purification phd in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What is a downstream protein purification PhD?

A Downstream Protein Purification PhD refers to an individual who has earned a doctoral degree specializing in the purification of proteins after they have been expressed in a host organism, typically as part of biopharmaceutical production. Downstream protein purification focuses on isolating, purifying, and characterizing target proteins from complex mixtures using various biochemical and biophysical methods. Professionals in this field are experts in techniques like chromatography, filtration, and centrifugation, ensuring the final product meets purity and quality standards required for research or therapeutic use.

What are the key skills and qualifications needed to thrive as a downstream protein purification PhD?

To thrive as a Downstream Protein Purification PhD, you need an advanced understanding of protein chemistry, chromatography, and bioprocess engineering, typically supported by a PhD in biochemistry, biotechnology, or a related field. Familiarity with purification systems (such as AKTA), analytical tools (like HPLC), and regulatory standards (cGMP) is crucial. Strong problem-solving, attention to detail, and effective communication help drive process optimization and successful collaboration with multidisciplinary teams. These skills ensure robust, scalable purification processes that meet quality and regulatory requirements in biopharmaceutical production.

What are some common challenges faced in a downstream protein purification PhD role and how can they be addressed?

One common challenge in a Downstream Protein Purification PhD role is optimizing purification protocols for novel or complex proteins, which often requires troubleshooting issues like low yield, aggregation, or impurities. Addressing these challenges typically involves iterative experimentation, staying updated on emerging purification technologies, and collaborating closely with upstream teams and analytical scientists. Additionally, balancing project timelines with the need for thorough documentation and compliance with regulatory standards is essential. Being proactive in cross-functional communication and leveraging automation or high-throughput techniques can also help streamline workflows and improve outcomes.

What is the difference between Downstream Protein Purification Phd vs Downstream Processing Scientist?

AspectDownstream Protein Purification PhdDownstream Processing Scientist
Required CredentialsPhD in Biochemistry, Molecular Biology, or related fieldBachelor's or Master's in Life Sciences or Chemical Engineering
Work EnvironmentResearch labs, biotech, pharmaceutical companiesManufacturing facilities, biotech, pharma industries
Employer & Industry UsageAcademic research, biotech R&D, pharmaceutical developmentProduction, process development, quality control

While both roles involve working with bioprocesses, a Downstream Protein Purification Phd typically focuses on advanced research and development of purification techniques, often in academic or R&D settings. In contrast, a Downstream Processing Scientist usually works in manufacturing environments, applying established protocols to produce and purify biotherapeutics at scale. The Phd role emphasizes innovation and experimental design, whereas the scientist role centers on process optimization and production efficiency.

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Downstream Protein Purification Phd jobs near you
Infographic showing various Downstream Protein Purification Phd job openings in the United States as of August 2026, with employment types broken down into 77% Full Time, 21% Part Time, and 2% Contract. Highlights an 73% Physical, 4% Hybrid, and 23% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

Scientist III, Protein Purification

Carlsbad, CA • On-site

Thermo Fisher Scientific
Biotechnology Research and Development • 10K+ employees

7.8

Company rating: 7.8 out of 10

Based on 429 frontline employees who took The Breakroom Quiz

170th of 545 rated manufacturers

People enjoy working here

Good employer

Recommended by students

Learn more about Thermo Fisher Scientificexternal

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 4 days ago

Job description

Work Schedule
Standard (Mon-Fri)
Environmental Conditions
Able to lift 40 lbs. without assistance, Adherence to all Good Manufacturing Practices (GMP) Safety Standards, Laboratory Setting, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.), Strong Odors (chemical, lubricants, biological products etc.), Will work with hazardous/toxic materials
Job Description
When you're part of the team at Thermo Fisher Scientific, you'll do important work. And you'll have the opportunity for continual growth and learning in a culture that empowers your development. With revenues of more than $40 billion and the largest investment in R&D in the industry, we give our people the resources and opportunities to make significant contributions to the world.
Location/Division-Specific Information:
Carlsbad, CA. Relocation assistance is NOT provided.
*Must be legally authorized to work in the United States without sponsorship.
*Must be able to pass a comprehensive background check, which includes a drug screen.
Discover Impactful Work
You will join a team performing all tasks related to protein purification. You will work in a controlled manufacturing laboratory environment using protein purification equipment and analytical techniques. As a Scientist III, you will also serve as a technical resource for purification processes, troubleshooting, and continuous improvement activities.
A Day in the Life
  • Purify protein products in a laboratory setting in accordance with standard operating procedures and controlled manufacturing documentation. Utilize laboratory techniques, calculations, materials measurement, equipment operation, and accurate record-keeping.
  • Perform column purification/chromatography, tangential flow filtration (TFF), buffer preparation, SDS-PAGE analysis, Western blotting, and other protein characterization techniques.
  • Operate Cytiva ÄKTA FPLC systems using UNICORN software and Bio-Rad NGC chromatography systems.
  • Apply specialized technical knowledge of protein purification and chromatography to make detailed observations, analyze process data, evaluate chromatograms, and ensure processes are operating within established parameters.
  • Independently identify and troubleshoot process, equipment, and product-related issues and recommend appropriate technical solutions.
  • Maintain accurate Batch Data Records, laboratory notebooks, work orders, equipment records, and other required documentation.
  • Maintain equipment, materials, product inventories, and related records as assigned.
  • Author and revise technical documents, including standard operating procedures and manufacturing batch records, within the requirements of the Quality Management System.
  • Lead or substantially contribute to process improvement activities to improve product quality, yield, process robustness, and productivity.
  • Support validation, qualification, investigations, and implementation of new or revised manufacturing processes as required.
  • Serve as a technical resource and provide guidance and training to less-experienced team members on protein purification processes and equipment.
  • Comply with all company safety procedures, Quality Management System requirements, and EH&S programs and maintain knowledge of Safety Data Sheets (SDSs) for relevant materials.
  • May perform other related duties as required and/or assigned.

Keys to Success:
Education
  • Bachelor's degree in Biology, Chemistry, Biochemistry, or another related discipline required. A Master's degree in a relevant field is preferred.
Experience
  • 5+ years of work experience in protein purification within a manufacturing environment or R&D laboratory.
  • Demonstrated hands-on experience with Cytiva ÄKTA FPLC systems and UNICORN software and/or Bio-Rad NGC chromatography systems.
  • Extensive experience with multiple chromatography modes, including affinity, ion-exchange, size-exclusion, and hydrophobic interaction chromatography, with a strong understanding of protein/resin interactions.
  • Demonstrated ability to independently troubleshoot protein purification processes and resolve technical problems using scientific principles and data analysis.
  • Experience with tangential flow filtration (TFF) and other downstream protein processing techniques.
  • Experience in executing validation or qualification protocols is preferred.
  • Experience working within a Quality Management System; experience with ISO 9001 and/or GMP environments is strongly preferred.

Knowledge, Skills, and Abilities
  • Strong theoretical and practical understanding of protein chemistry, chromatography methods, and protein purification techniques.
  • Demonstrated scientific troubleshooting and problem-solving skills.
  • Ability to independently execute scientific procedures, analyze results, and identify opportunities for process improvement.
  • Results-oriented and data-driven with excellent attention to detail and documentation practices.
  • Proactive approach that anticipates needs and problems while developing effective solutions.
  • Strong collaborative and communication skills with the ability to provide technical guidance and influence others without direct authority.
  • Ability to manage multiple priorities effectively in a manufacturing environment.
  • Working knowledge of manufacturing-related computer software preferred.
  • Intermediate Excel skills.

Working Conditions
  • Works in a clean, controlled manufacturing laboratory environment with specialized equipment.
  • Regularly required to lift up to 20 pounds. May occasionally be required to lift 45 pounds or more with assistance and/or appropriate equipment.
  • May be required to stand for extended periods while performing duties.
  • Must be flexible to work varying schedules and hours as needed.
  • Must be able to work safely with chemicals and hazardous materials.
  • Must be able to work in a +4°C cold room.

Benefits:
We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!
Compensation and Benefits
The salary range estimated for this position based in California is $83,300.00-$100,000.00.
This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
  • A choice of national medical and dental plans, and a national vision plan, including health incentive programs
  • Employee assistance and family support programs, including commuter benefits and tuition reimbursement
  • At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
  • Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
  • Employees' Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards

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