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Downstream Protein Purification Phd Jobs (NOW HIRING)

SIGNOBIO INC

Downstream Associate

Houston, TX · On-site

Responsibilities include chromatography-based purification, recombinant protein QC related tasks ... Execute established downstream workflows to meet project specifications and client requirements.

Caltech

Research Technician

Pasadena, CA · On-site

$19 - $25.75/hr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Harvest cells and assist with downstream, protein purification (modern chromatography methods). * Perform immunofluorescence microscopy to assess protein localization. * Conduct SDS-PAGE gel analysis ...

Alloy Therapeutics

Associate Scientist, Protein Science

Waltham, MA · On-site

$93K - $110K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

The ideal candidate will bring hands-on experience with mammalian cell transfection, recombinant DNA techniques, and a working familiarity with downstream protein purification. We are looking for ...

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How much do downstream protein purification phd jobs pay per hour?

As of Aug 18, 2026, the average hourly pay for downstream protein purification phd in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What is a downstream protein purification PhD?

A Downstream Protein Purification PhD refers to an individual who has earned a doctoral degree specializing in the purification of proteins after they have been expressed in a host organism, typically as part of biopharmaceutical production. Downstream protein purification focuses on isolating, purifying, and characterizing target proteins from complex mixtures using various biochemical and biophysical methods. Professionals in this field are experts in techniques like chromatography, filtration, and centrifugation, ensuring the final product meets purity and quality standards required for research or therapeutic use.

What are the key skills and qualifications needed to thrive as a downstream protein purification PhD?

To thrive as a Downstream Protein Purification PhD, you need an advanced understanding of protein chemistry, chromatography, and bioprocess engineering, typically supported by a PhD in biochemistry, biotechnology, or a related field. Familiarity with purification systems (such as AKTA), analytical tools (like HPLC), and regulatory standards (cGMP) is crucial. Strong problem-solving, attention to detail, and effective communication help drive process optimization and successful collaboration with multidisciplinary teams. These skills ensure robust, scalable purification processes that meet quality and regulatory requirements in biopharmaceutical production.

What are some common challenges faced in a downstream protein purification PhD role and how can they be addressed?

One common challenge in a Downstream Protein Purification PhD role is optimizing purification protocols for novel or complex proteins, which often requires troubleshooting issues like low yield, aggregation, or impurities. Addressing these challenges typically involves iterative experimentation, staying updated on emerging purification technologies, and collaborating closely with upstream teams and analytical scientists. Additionally, balancing project timelines with the need for thorough documentation and compliance with regulatory standards is essential. Being proactive in cross-functional communication and leveraging automation or high-throughput techniques can also help streamline workflows and improve outcomes.

What is the difference between Downstream Protein Purification Phd vs Downstream Processing Scientist?

AspectDownstream Protein Purification PhdDownstream Processing Scientist
Required CredentialsPhD in Biochemistry, Molecular Biology, or related fieldBachelor's or Master's in Life Sciences or Chemical Engineering
Work EnvironmentResearch labs, biotech, pharmaceutical companiesManufacturing facilities, biotech, pharma industries
Employer & Industry UsageAcademic research, biotech R&D, pharmaceutical developmentProduction, process development, quality control

While both roles involve working with bioprocesses, a Downstream Protein Purification Phd typically focuses on advanced research and development of purification techniques, often in academic or R&D settings. In contrast, a Downstream Processing Scientist usually works in manufacturing environments, applying established protocols to produce and purify biotherapeutics at scale. The Phd role emphasizes innovation and experimental design, whereas the scientist role centers on process optimization and production efficiency.

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Downstream Protein Purification Phd jobs near you
Infographic showing various Downstream Protein Purification Phd job openings in the United States as of August 2026, with employment types broken down into 77% Full Time, 21% Part Time, and 2% Contract. Highlights an 73% Physical, 4% Hybrid, and 23% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

Scientist / Protein Purification

Pioneer Data

Cambridge, MA • On-site

Contractor

Posted 3 days ago

New

Job description

Position Details:
Our client, a world-leading Pharmaceutical Company in Cambridge, MA is currently looking for an Scientist to join their expanding team.
 
Job Title: Scientist / Protein Purification
Duration: 24 months contract, extendable up to 48 months
Location: Cambridge, MA
 
Note:
The client has the right-to-hire you as a permanent employee at any time during or after the end of the contract.
You may participate in the company group medical insurance plan
 
Job Description:
We are seeking a motivated Bench Scientist to join a biotherapeutics research team in Cambridge, MA.
This is a hands-on laboratory position focused primarily on recombinant protein expression, purification, and characterization to support downstream biotherapeutic research.

Key Responsibilities
Perform routine recombinant protein purification using FPLC/AKTA and related chromatography techniques.
Support the production of recombinant proteins and antigens for downstream biotherapeutic research.
Participate in protein expression workflows and, as needed, molecular biology/DNA-related activities.
Perform protein characterization and assess protein quality, purity, concentration, and suitability for downstream applications.
Work with antigens, antibodies, mAbs, Fabs, and other recombinant proteins.
Perform routine protein labeling and conjugation, including fluorescent and biotin labeling.
Assist with analytical techniques such as SDS-PAGE, Western blotting, and HPLC.
Maintain accurate laboratory records, sample tracking, and experimental documentation.
Manage multiple protein-production and purification requests while meeting project timelines.
Work collaboratively with scientists across the research organization and provide purified proteins for downstream studies.
Maintain a clean, organized, and compliant laboratory environment and follow all required laboratory safety and PPE procedures.

Required Qualifications
Bachelor's degree in Biochemistry, Biology, Chemistry, Molecular Biology, or a related scientific discipline.
At least 1 year of hands-on experience with recombinant protein purification or a closely related protein-science discipline.
Hands-on experience with AKTA/FPLC or comparable chromatography systems.
Understanding of protein purification and characterization principles.
Strong laboratory organization and time-management skills.
Ability to work effectively in a collaborative, fast-paced research environment.

Preferred Qualifications
Master's degree in Biochemistry, Biology, Biophysics, Molecular Biology, or a related field.
Experience with recombinant protein expression.
Experience with protein biophysics and protein characterization.
Experience working with antibodies, mAbs, Fabs, or recombinant antigens.
Background in immunology or biotherapeutic research.