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Downstream Protein Purification Phd Jobs (NOW HIRING)

BioTalent

Associate Researcher

Tustin, CA · On-site

Support downstream process development and routine purification of monoclonal antibodies and recombinant proteins. * Assist with chromatography method development and execution for protein ...

Caltech

Research Technician

Pasadena, CA · On-site

$19 - $25.75/hr

Harvest cells and assist with downstream, protein purification (modern chromatography methods). * Perform immunofluorescence microscopy to assess protein localization. * Conduct SDS-PAGE gel analysis ...

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How much do downstream protein purification phd jobs pay per hour?

As of Jul 27, 2026, the average hourly pay for downstream protein purification phd in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Downstream Protein Purification PhD, and why are they important?

To thrive as a Downstream Protein Purification PhD, you need an advanced understanding of protein chemistry, chromatography, and bioprocess engineering, typically supported by a PhD in biochemistry, biotechnology, or a related field. Familiarity with purification systems (such as AKTA), analytical tools (like HPLC), and regulatory standards (cGMP) is crucial. Strong problem-solving, attention to detail, and effective communication help drive process optimization and successful collaboration with multidisciplinary teams. These skills ensure robust, scalable purification processes that meet quality and regulatory requirements in biopharmaceutical production.

What is the difference between Downstream Protein Purification Phd vs Downstream Processing Scientist?

AspectDownstream Protein Purification PhdDownstream Processing Scientist
Required CredentialsPhD in Biochemistry, Molecular Biology, or related fieldBachelor's or Master's in Life Sciences or Chemical Engineering
Work EnvironmentResearch labs, biotech, pharmaceutical companiesManufacturing facilities, biotech, pharma industries
Employer & Industry UsageAcademic research, biotech R&D, pharmaceutical developmentProduction, process development, quality control

While both roles involve working with bioprocesses, a Downstream Protein Purification Phd typically focuses on advanced research and development of purification techniques, often in academic or R&D settings. In contrast, a Downstream Processing Scientist usually works in manufacturing environments, applying established protocols to produce and purify biotherapeutics at scale. The Phd role emphasizes innovation and experimental design, whereas the scientist role centers on process optimization and production efficiency.

What is a Downstream Protein Purification PhD?

A Downstream Protein Purification PhD refers to an individual who has earned a doctoral degree specializing in the purification of proteins after they have been expressed in a host organism, typically as part of biopharmaceutical production. Downstream protein purification focuses on isolating, purifying, and characterizing target proteins from complex mixtures using various biochemical and biophysical methods. Professionals in this field are experts in techniques like chromatography, filtration, and centrifugation, ensuring the final product meets purity and quality standards required for research or therapeutic use.

What are some common challenges faced in a Downstream Protein Purification PhD role and how can they be addressed?

One common challenge in a Downstream Protein Purification PhD role is optimizing purification protocols for novel or complex proteins, which often requires troubleshooting issues like low yield, aggregation, or impurities. Addressing these challenges typically involves iterative experimentation, staying updated on emerging purification technologies, and collaborating closely with upstream teams and analytical scientists. Additionally, balancing project timelines with the need for thorough documentation and compliance with regulatory standards is essential. Being proactive in cross-functional communication and leveraging automation or high-throughput techniques can also help streamline workflows and improve outcomes.
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Downstream Protein Purification Phd jobs near you
Infographic showing various Downstream Protein Purification Phd job openings in the United States as of July 2026, with employment types broken down into 95% Full Time, 1% Part Time, and 4% Contract. Highlights an 84% Physical, 4% Hybrid, and 12% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

DOWNSTREAM PROCESS DEVELOPMENT SCIENTIST

MyGradJob

Billerica, MA

Other

Posted 4 days ago

Job description

Company Description

MilliporeSigma is the North American life science brand of Merck KGaA, Darmstadt, Germany - a leading science and technology company. It offers a broad range of innovative products and services to biotech and pharmaceutical drug therapies businesses. Through dedicated collaboration with the scientific and engineering communities, and as one of the top three R&D investors in the life science tools industry, the brand serves as a strategic partner to customers and helps advance the promise of life science.

Job Description
  • Design fit-for-purpose purification experiments according to the stage of development
  • Ensure scientific evaluation of impact of deviations to Downstream validation studies
  • Compile and analyze experimental data to generate process knowledge and decide on next steps
  • Write development and validation reports and ensure their timely delivery
  • Prepare and present project updates to global project team and to upper management
  • Ensure a continuous improvement within Downstream process development activities
  • Represent & promote E2E and Biodevelopment activities (presentations, congresses, events)
  • Technical lead on the overall projects (supervises Downstream processes development and implementation of new methods and services)
  • Technical leader for equipment, technologies for Downstream process development
  • Responsible for activities ranging from protein purification, filtration, biochemical and biophysical characterization of proteins: -
  • Execute routine protein purification with affinity, size exclusion, ion exchange, and hydrophobic interaction chromatography using AKTA systems (Unicorn software)
  • Perform analyses including but not limited to SDS-PAGE, SE-HPLC, LAL, host cell-DNA, host cell protein, as necessary
  • To develop, validate and transfer robust analytical methods required for successful drug development and manufacturing.
  • To support follow-up and troubleshooting on analytical methods.
  • Provide expertise and insight to guide development of appropriate purification methods
  • Develop novel purification processes as well as using standard methods to purify proteins from the mg to gram scale. Processes will be multiple steps and must provide necessary clearance of viruses, endotoxin, and host cell proteins and DNA.
  • Perform, develop and optimize robust, efficient, scalable strategies for improving process performance. Activities will include small-scale studies and pilot scale purification studies.
  • Apply DOE methods to purification activities
Qualifications
  • Engineering/Master degree (PhD preferred) in biotechnology with 5+ years in the biopharmaceutical industry
  • Solid and proven theoretical basis and hands-on experience in protein purification and analytical characterization
  • Hands-on experience with purification unit operations including filtration, chromatography, TFF, UF/DF, AKTA, UNICORN and HPLC systems.
  • Strong hands-on experience in troubleshooting and routine instrument maintenance.
  • Experienced in protein purification via affinity, hydrophobic interaction (HIC), ion exchange (IEX), size exclusion (SEC) and mixed-mode chromatography
  • Knowledge and skills in biochemical characterization of proteins including analytical and biophysical
  • Proven track record in Purification Process Development is necessary with emphasis on chromatographic separations and excellent understanding of and experience with chromatographic resin screening and process optimization.  Experience with scale-up and GMP manufacturing is desirable.
  • Solid and proven working knowledge of DOE. Ability to critically analyze data using statistical tools and to compile technical reports
  • Excellent presentation and communication skills
  • Results-oriented with ability to work and deliver under pressure
  • Excellent English (written, oral) 
Additional Information

All your information will be kept confidential according to EEO guidelines.

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