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Process Optimization Jobs in Indiana (NOW HIRING)

Mural Group

Senior Maintenance Manager

Evansville, IN

$150K - $175K/yr

Position Overview Mural Group is partnering with a global manufacturing organization to hire a Process Engineering & Maintenance Manager to lead both process optimization and equipment reliability ...

JASPER SEATING COMPANY, Inc.

Process Engineer

IN · On-site

Description A Process Engineer at Jasper Group is responsible for designing, implementing, and optimizing procedures and equipment in the metal fabrication and powder coating manufacturing process.

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How much do process optimization jobs pay per hour?

As of May 30, 2026, the average hourly pay for process optimization in Indiana is $29.58, according to ZipRecruiter salary data. Most workers in this role earn between $25.62 and $35.24 per hour, depending on experience, location, and employer.

What is a Process Optimization job?

A Process Optimization job focuses on analyzing, improving, and streamlining workflows to enhance efficiency, reduce costs, and improve overall performance. Professionals in this role use data analysis, automation, and best practices to identify bottlenecks and implement solutions. They often collaborate with cross-functional teams to drive continuous improvement and ensure sustainable operational success. Depending on the industry, this role may involve Lean, Six Sigma, or other methodologies to optimize business processes.

What are the key skills and qualifications needed to thrive in the Process Optimization position, and why are they important?

To thrive in Process Optimization, you need strong analytical skills, a background in process engineering or industrial engineering, and often a relevant degree in engineering, business, or operations management. Familiarity with process mapping software, Lean Six Sigma methodologies, and data analysis tools such as Excel, Minitab, or Tableau is commonly required, with certifications like Lean Six Sigma Green or Black Belt being advantageous. Exceptional problem-solving abilities, communication skills, and a collaborative mindset help candidates stand out in this role. These skills are crucial for identifying inefficiencies, facilitating improvements, and driving measurable results across diverse business operations.

What does a typical day look like for someone working in Process Optimization?

A typical day for a Process Optimization professional involves analyzing current workflows, identifying areas for improvement, and collaborating with cross-functional teams to implement solutions. You may spend time mapping out processes, conducting data analysis, and facilitating meetings or workshops to gather input and drive change. The role often requires balancing hands-on problem solving with documentation and reporting progress to stakeholders. Close collaboration with departments such as production, quality assurance, and IT is common to ensure sustainable improvements. These varied responsibilities keep the work dynamic and provide opportunities for ongoing learning and impact.

What does process optimization do?

Process optimization involves analyzing and improving business processes to increase efficiency, reduce costs, and enhance quality. Process optimization professionals use tools like data analysis and workflow redesign to streamline operations and achieve better performance outcomes.

What job pays $400,000 a year without a degree?

In process optimization, high-paying roles often require extensive experience and specialized skills rather than formal degrees. Positions such as senior consultants or operations managers in certain industries can reach or exceed $400,000 annually, especially with bonuses and performance incentives, but typically demand strong expertise, certifications, and proven results.
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What are the most commonly searched types of Process Optimization jobs in Indiana? The most popular types of Process Optimization jobs in Indiana are:
What are popular job titles related to Process Optimization jobs in Indiana? For Process Optimization jobs in Indiana, the most frequently searched job titles are:
What job categories do people searching Process Optimization jobs in Indiana look for? The top searched job categories for Process Optimization jobs in Indiana are:
Process Optimization jobs near you
Infographic showing various Process Optimization job openings in Indiana as of May 2026, with employment types broken down into 1% As Needed, 79% Full Time, 17% Part Time, and 3% Contract. Highlights an 99% Physical, and 1% Remote job distribution, with an average salary of $61,534 per year, or $29.6 per hour.
Principal Process Engineer - API External Manufacturing (Small Molecule)

Principal Process Engineer - API External Manufacturing (Small Molecule)

Eli Lilly and Company

Indianapolis, IN • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 27 days ago

Eli Lilly and Company rating

8.8

Company rating: 8.8 out of 10

Based on 62 frontline employees who took The Breakroom Quiz

11th of 70 rated pharmaceutical

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Position Brand Description:
The position of Principle Process Engineer - API EM Small Molecule reports to the API EM Engineering Director and provides technical leadership and expertise in conjunction with API EM contract manufacturer personnel in the reliable supply and commercialization of medicines with safety first and quality always by:
  • Developing and sustaining process knowledge in order to ensure the execution of the appropriate product, process, and operational control strategy at a number of Contract Manufacturers (CMs)
  • Assessment of the suitability of proposed equipment sets to ensure success of process validations
  • Direct and Indirect interaction with CM personnel to ensure reliable supply via the CM execution of the operational control strategy
  • FUME assessment to ensure an understanding of risk presented to the operational control strategy
  • Participation with internal or CM resources in the equipment specification, procurement, and IQ/OQ/PQ
  • Participation with internal and CM resources to assess the HSE and PSM elements of the CM that impact Lilly products
  • Engaged with internal and external resources in developing capabilities with new or evolving technologies that may impact delivery of internal or external portfolio assets.
  • Adherence to the expectations of the Lilly Red Book when carrying out interactions with API EM's CMs.

Key Objectives/Deliverables:
Coach and Mentor Process Team Members
  • Utilize past experiences with unit operation control to provide insight and feedback to members of the CM Joint Process Team (JPT).
  • Champion the application of statistical thinking and use of data to monitor process performance and make engineering decisions with CM members of the JPT.
  • Support and peer review root cause analysis around FUME and operational incidents.
  • Peer review documentation of learning points, technical studies, and incident investigations.

Scale-Up & Tech Transfer
  • Lead/support tech transfers and scale-up from development through PV and commercial supply.
  • Translate process intent into operating strategies, equipment fit/gap, batch documentation, and PV readiness at CMs.
  • Support engineering runs and PV readiness through parameter optimization and performance trending.

Develop and Sustain Process Knowledge
  • Identify process knowledge gaps that impact equipment and process capability.
  • Develop or support the capture of key process knowledge (examples include material and energy balances, kinetics, chemistry, process modeling, and equipment design basis).
  • Enable the development and maintenance of process knowledge. infrastructure such as key models, report history, lab models, and literature.
  • Utilize optimization resources and tools for process analysis and process improvement studies.
  • Review and track key process engineering metrics.

Provide Process & Equipment Support:
  • Identify systemic issues affecting production and reliable supply from CMs
  • Lead or participate in root cause analysis and countermeasure development and implementation for major safety, quality, or throughput incident investigations. Perform reviews of incident documentation for technical accuracy.
  • Review and approve documentation and engineering decisions.

Process Optimization & Continuous Improvement:
  • Support development and technical analysis for on-going continuous improvement activities.
  • Review and identify cost reduction opportunities, as well as process capacities and bottlenecks. Assist in prioritization of opportunities with respect to overall business objectives.
  • Work with the CMs to ensure the application of statistical thinking and methods to understand process variability and capability.
  • Perform and promote optimization of unit operation cycle time, loading, and yield performance.
  • Engage with late phase development and Engineering Technical Center resources to ensure staying contemporary with key engineering disciplines and developing portfolio platforms (e.g. continuous manufacturing operations).

Equipment Capability and Asset Management:
  • Create an appropriate methodology to ensure visibility of the ongoing state of qualification of key FUME systems at the CMs.
  • Review equipment and process system user requirements and qualification plans to ensure that the equipment and systems are appropriate for the intended purpose.
  • Act as customer representative for review of Contact Manufacturer (CM) requests for capital projects targeted at both short- and long-term needs.

Oversight of HSE and PSM:
  • Serve as the liaison for API EM and Global HSE on health, safety, and environmental (HSE) and process safety management (PSM) oversight at the relevant contract manufacturing sites.
  • Leverage internal Lilly experts in HSE and PSM to ensure appropriate risk reduction at CMs.
  • Participate in Lilly HSE and PSM audits of contract manufacturing sites as applicable.
  • Maintain key HSE and PSM metrics for review within API EM.

Adherence to Business, Quality, and Financial Systems:
  • Understand and follow all applicable Lilly policies and procedures with respect to interactions and oversight of API contract manufacturing sites.

Basic Requirements:
  • Bachelor of Science degree in Chemical Engineering, or another engineering discipline with extensive chemical manufacturing experience.
  • 3+ years of work experience in a manufacturing/process engineering related role related to small molecules.
  • Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Additional Preferences:
  • Experience in typical unit operations for Small Molecule API Manufacturing
  • Deep technical knowledge of API / Drug Substance manufacturing equipment and unit operations.
  • Demonstrated ability to apply fundamental chemical engineering principles to process understanding, problem solving, and process improvement.
  • Demonstrated ability to function in a team environment as a technical leader and as a member of teams.
  • Demonstrated ability to manage and prioritize competing priorities and to appropriately communicate verbally and in writing to various audiences.
  • Develop and implement innovative approaches to problems
  • Process Hazard Analysis experience
  • Successful application of root cause analysis and systematic problem solving
  • Strong Computer skills in a variety of software packages ( e.g Batch Plus, JMP, Visio, Aspen, Dynochem, OSI PI, MS Office Suite).
  • Visualize an operation/process and reflect it in a model.

Other Information:
  • This role is located onsite in Indianapolis, IN with the ability to work from home up to 4 days per month. Relocation assistance will be provided if applicable.
  • This role is not approved for 100% remote work
  • Travel may routinely be required to support process start-ups, troubleshooting, and commercial manufacturing. This travel is typically in the range of 15% to 25% annually, depending on the needs of the process(s).

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$66,000 - $171,600
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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About Eli Lilly

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Eli Lilly, based in Indianapolis, IN, US, is one of the pioneers in the pharmaceutical industry with a rich history dating back to 1876. This global pharmaceutical company focuses on discovering, developing, manufacturing and selling pharmaceutical products in approximately 120 countries. The company's product categories include endocrinology, oncology, cardiovascular, neuroscience, and immunology. Having invested over $9 billion in research and development in the past decade, Eli Lilly is also committed to creating high-quality medicines that meet real needs. As a recipient of several awards and recognitions, Eli Lilly is known for its focus on life-saving research and drug development. Their mission is to make medicines that help people live longer, healthier, and more active lives.

Industry

Pharmaceutical product wholesalers

Company size

10,000+ Employees

Headquarters location

Indianapolis, IN, US

Year founded

1876

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