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It Infrastructure Manager Jobs (NOW HIRING)

GW Electric

$111K - $148K/yr

Develop and execute short-term and long-term IT infrastructure strategies to support business ... Oversee and manage enterprise-wide IT infrastructure, including data centers, servers, storage ...

Casne Engineering, Inc.

Be Seen First

IT Infrastructure Engineer

Bellevue, WA · On-site

$90K - $110K/yr

IT Infrastructure Engineer Casne Engineering is seeking an IT Infrastructure Engineer to lead the ... Manage VMware vSphere hypervisors and virtual machine infrastructure across multiple sites.

Austal USA LLC

Manager IT Infrastructure

Mobile, AL · On-site

The Manager of IT Infrastructure is responsible for leading the teams that maintain systems, networking, database, and datacenter infrastructure. This role includes managing individual contributors ...

Alcon

IT Site Infrastructure Manager

Johns Creek, GA · On-site

As a IT Site Infrastructure Manager supporting the Manufacturing & Technical Operations (MTO) Team in Johns Creek, GA. You will be responsible for the lifecycle management of infrastructure, driving ...

Austal USA

Manager IT Infrastructure

Mobile, AL · On-site

Austal USA is a leader in the shipbuilding industry, and they are seeking a Manager of IT Infrastructure to lead teams responsible for maintaining systems, networking, database, and datacenter ...

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It Infrastructure Manager information

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$69K

$123.6K

$181.5K

How much do it infrastructure manager jobs pay per year?

As of Jul 11, 2026, the average yearly pay for it infrastructure manager in the United States is $123,647.00, according to ZipRecruiter salary data. Most workers in this role earn between $98,000.00 and $146,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an IT Infrastructure Manager, and why are they important?

To thrive as an IT Infrastructure Manager, you need a solid background in IT systems, network administration, and project management, often supported by a bachelor's degree in computer science or related fields. Familiarity with virtualization platforms, cloud services (like AWS or Azure), and certifications such as ITIL or Cisco are typically essential. Leadership, problem-solving, and strong communication skills help you effectively manage teams and coordinate with stakeholders. These skills are crucial for ensuring reliable IT operations, efficient project delivery, and alignment with organizational goals.

What is the role of IT infrastructure management?

IT infrastructure management involves overseeing and maintaining an organization's hardware, software, networks, and data centers to ensure reliable and secure IT operations. It includes tasks such as system deployment, monitoring, troubleshooting, and implementing security protocols, often requiring knowledge of tools like network management systems and certifications such as ITIL or CompTIA. Effective management supports business continuity and technological efficiency.

What does an IT Infrastructure Manager do?

An IT Infrastructure Manager is responsible for overseeing the design, implementation, and maintenance of an organization's technology infrastructure, including servers, networks, and data storage. They ensure that all IT systems are secure, reliable, and meet the company's needs. This role involves managing IT staff, coordinating with other departments, and planning for future technology upgrades or expansions. Additionally, IT Infrastructure Managers are often responsible for disaster recovery planning and ensuring compliance with relevant regulations.

What are the 4 types of IT infrastructure?

As an IT Infrastructure Manager, understanding the four main types of IT infrastructure is essential. These include hardware infrastructure (servers, storage, networking equipment), software infrastructure (operating systems, enterprise applications), network infrastructure (routers, switches, internet connectivity), and data center infrastructure (physical facilities, power, cooling). Managing these components ensures reliable and secure IT operations within an organization.

What is the difference between It Infrastructure Manager vs Network Administrator?

AspectIt Infrastructure ManagerNetwork Administrator
ResponsibilitiesOversees entire IT infrastructure, including servers, storage, and network systems; manages teams and strategic planningMaintains and supports network hardware, software, and security; ensures network connectivity and performance
CertificationsITIL, PMP, Cisco, Microsoft certifications often preferredCCNA, CompTIA Network+, Cisco certifications
Work EnvironmentLeadership roles in IT departments, strategic planning, vendor managementHands-on technical work, troubleshooting, network configuration

The main difference is that an It Infrastructure Manager oversees the entire IT infrastructure and manages teams, while a Network Administrator focuses on maintaining and supporting network systems. The Infrastructure Manager has broader strategic responsibilities, whereas the Network Administrator handles day-to-day network operations.

What is the role of IT infrastructure manager?

An IT infrastructure manager oversees the planning, implementation, and maintenance of an organization’s IT systems, including networks, servers, and hardware. They ensure the reliability, security, and efficiency of technology infrastructure, often managing teams and working with tools like cloud platforms and network security protocols.

How does an IT Infrastructure Manager typically collaborate with other departments to ensure seamless technology operations?

An IT Infrastructure Manager works closely with various departments such as security, application development, and business operations to ensure that technology systems align with organizational needs. This involves regular meetings to understand requirements, coordinating system upgrades or migrations, and addressing any technical challenges that may impact other teams. Effective communication and cross-functional collaboration are essential, as the manager often acts as a bridge between technical staff and non-technical stakeholders. Building strong relationships helps proactively identify issues and implement solutions that support the entire organization's objectives.

How much do IT infrastructure managers make in the US?

IT Infrastructure Managers in the US typically earn a median annual salary of around $100,000 to $130,000, depending on experience, certifications, and location. Senior roles or those with specialized skills in cloud computing and network security can earn higher salaries, often exceeding $150,000 annually.
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It Infrastructure Manager jobs near you
Infographic showing various It Infrastructure Manager job openings in the United States as of July 2026, with employment types broken down into 95% Full Time, 3% Part Time, and 2% Contract. Highlights an 86% Physical, 4% Hybrid, and 10% Remote job distribution, with an average salary of $123,647 per year, or $59.4 per hour.
IT Infrastructure Manager

IT Infrastructure Manager

Lyell Immunopharma

South San Francisco, CA • On-site

Full-time

Posted 24 days ago

Job description

Using living cells to treat - and sometimes even cure - cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response. We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell's product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency.
This role will be based out of South San Francisco, California, and reports to the Director, IT Infrastructure & Operations.
POSITION SUMMARY:
The individual in this role serves as the internal technical expert for Lyell's infrastructure, cloud, identity, and collaboration environments. This is a hands-on individual contributor role responsible for the configuration, implementation, and ongoing operation of these platforms in partnership with Lyell's managed service provider (MSP). Acting as the bridge between business requirements and infrastructure, this person translates stakeholder needs into scalable, compliant solutions and ensures Lyell operates reliable, validated infrastructure in a regulated life sciences environment.
KEY ROLE AND RESPONSIBILITIES:
  • Design and build infrastructure across cloud (AWS), on-premises, networking, identity, and collaboration platforms in line with best practices, industry standards, and Lyell's technology strategy.
  • Translate approved architectures and designs into detailed configurations and implementation plans; execute builds and changes, validate against requirements, and hand off steady-state operations to the MSP while retaining configuration and implementation ownership
  • Provide key technical input and feedback into architecture standards, infrastructure strategy, and roadmap planning led by IT leadership - drawing on hands-on knowledge of platform capabilities, constraints, and operational realities - and maintain up-to-date documentation of systems configuration and project status
  • Own the configuration, operation, and optimization of Lyell's AWS environment - implementing governance, cost management, and security controls per defined standards and identifying opportunities to optimize and maximize the value of Lyell's infrastructure investment.
  • Configure and maintain on-premises server and network systems, including VMware vSphere clusters, Windows Server, Active Directory, and network platforms (Juniper, Cisco Meraki, Palo Alto Networks) spanning routing, switching, firewall policy, and segmentation.
  • Ensure backup and disaster recovery integrity (e.g., Veeam), including monitoring backup health and resolving exceptions, and manage VPN, and telecommunications infrastructure.
  • Own the configuration, and governance of Okta, Microsoft 365, Zoom, and Slack as core infrastructure platforms, ensuring identity, access, and collaboration systems meet security, audit, and compliance requirements (e.g., access reviews, joiner/mover/leaver, audit logging).
  • Support lab infrastructure, including associated software and attached instrumentation.
  • Serve as primary day-to-day contact and technical authority over the MSP: define scope, review performance against SLAs, oversee implementation to ensure adherence to defined architecture, and ensure service delivery aligns with ITIL practices (incident, problem, change, and request management).
  • Act as the Tier 3 escalation point for the service desk, personally resolving complex or time-sensitive infrastructure incidents during business hours and providing guidance to service desk staff on end-user computing systems.
  • Participate in vendor evaluations, SOW reviews, supplier and hosted-solution oversight, and ongoing contract governance.
  • Own security tooling configuration per confirmed architecture (EDR, SIEM, and related platforms), and partner with the validation team on computer system validation (CSV) to ensure infrastructure designs support compliant, audit-ready operations and SOX and GxP audit activities.
  • Own the configuration, administration, and governance of Lyell's enterprise AI platforms - primarily Anthropic Claude - including user provisioning and access controls, workspace and policy configuration, integration with identity and collaboration systems, and usage monitoring, while partnering with compliance teams to ensure responsible, audit-ready use that meets the company's data-protection and regulatory requirements.

PREFERRED EDUCATION & EXPERIENCE:
  • BA/BS in an information technology field, or equivalent experience, with a minimum of 10 years in IT infrastructure, including 8+ years of hands-on solution architecture, technical design, and implementation across cloud, on-premises, and networking environments.
  • Demonstrated experience in a life sciences or biotech environment, including an understanding of GxP, validated systems, and regulated IT operations.
  • Deep AWS expertise - system engineering, cost governance, security, and operational best practices.
  • Extensive experience with Windows Server, VMware vSphere, and Active Directory across macOS, Windows, and Linux systems.
  • Hands-on administration and governance experience with Okta, Microsoft 365, Zoom, and Slack.
  • Strong network administration experience and fundamentals (routing, switching, firewall rules, segmentation), with hands-on experience on platforms such as Cisco Meraki and Palo Alto Networks.
  • Experience managing and monitoring system backups (e.g., Veeam), and managing VPN, telecommunications, and video conferencing solutions.
  • Experience with one or more scripting/automation languages (Python, PowerShell, Ruby, or equivalent) or leveraging AI or other workflow automation tools to automate repeatable work
  • Experience managing or overseeing MSP or third-party service delivery relationships, and serving as a Tier 3 escalation point for service desk or operations teams.
  • Familiarity administering or governing enterprise AI platforms (Anthropic Claude or equivalent), including user and workspace administration, access and policy controls, and responsible-use, data-protection, and compliance considerations.

KNOWLEDGE, SKILLS AND ABILITIES:
  • Prior experience working in the life sciences or biotech industry, with a working understanding of how IT operates in a regulated, GxP environment.
  • Comfortable working hands-on daily - designing and governing, but also personally executing and resolving incidents when speed or quality demands it.
  • Strong vendor management instincts - able to lead by influence rather than direct authority, push back, hold partners accountable, and escalate appropriately.
  • Excellent problem-solving, analytical, and decision-making skills, with the ability to navigate complex technical trade-offs and manage large projects.
  • Ability to produce clear system documentation and standards that others can execute against.
  • Excellent written and verbal communication skills; able to convey technical concepts to both technical and non-technical audiences and interact with leadership.
  • Ability to work independently and collaboratively across cross-functional teams, prioritize workflow, meet deadlines, and balance competing priorities.
  • Preferred: AWS certifications (Solutions Architect, Security Specialty, SysOps, or DevOps Engineer); experience with infrastructure-as-code tooling (Terraform, CloudFormation, or equivalent);

The salary range for this position is $175,000 to $195,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell's compensation practices and an applicant's qualifications and experience. Employees are also eligible to participate in Lyell's Equity Incentive Plan.
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
We've learned from experience that some of the best people don't always match our requirements perfectly - if you're interested and think you could fit, please don't hesitate to apply.

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