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How much do downstream processing jobs pay per hour?

As of May 30, 2026, the average hourly pay for downstream processing in the United States is $24.67, according to ZipRecruiter salary data. Most workers in this role earn between $19.71 and $28.12 per hour, depending on experience, location, and employer.

What is a Downstream Processing job?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are the key skills and qualifications needed to thrive in the Downstream Processing position, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What are the typical daily responsibilities of someone working in Downstream Processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.
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Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in the United States as of May 2026, with employment types broken down into 1% As Needed, 94% Full Time, 1% Temporary, and 4% Contract. Highlights an 30% Physical, and 70% Remote job distribution, with an average salary of $51,319 per year, or $24.7 per hour.
Pilot Plant Downstream Processing Operator

Pilot Plant Downstream Processing Operator

Manus Bio

Augusta, GA • On-site

Full-time

Posted 11 days ago

Job description

Manus works across industries and value chains to accelerate the transition to BioAlternatives - better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today. We are seeking a highly motivated Pilot Plant Downstream Processing Operator. This person will be expected to play an integral part of Manus' manufacturing and process development team located in Augusta, GA.
The Pilot Plant Downstream Processing Operator is responsible for the continuing efficient operation of the pilot plant. This includes maintenance, equipment reliability, and operations. Creativity and decision-making skills are required. Must be able to maintain a good working relationship with all personnel. Work as a member of the pilot plant team which includes assisting both with fermentation and downstream work assignments. Controls, monitors, and measures processes as instructed. Abides by all safely, environmental, and quality requirements. Perform minor maintenance and duties related to product testing, including sampling.
Why work at Manus:
  • Opportunity - For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
  • Accountability - You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
  • Passion - We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that come with working on the cutting edge.

Responsibilities:
Interface with process development team to provide resources to solve fermentation and product isolation challenges. Execute and help evaluate experiments. This activity includes:
  • Perform downstream purification operations including centrifugation, chromatography (e.g., affinity, ion exchange), filtration (TFF, depth, sterile).
  • Set up, operate, and clean process equipment such as columns, tanks, and filtration systems.
  • Collect, label, and process in-process and final product samples.
  • Monitor process parameters, record data, and ensure batch documentation is completed accurately.
  • Perform cleaning and sterilization of equipment and cleanroom areas (CIP/SIP procedures).
  • Assist in deviation investigations and continuous improvement initiatives.
  • Collaborate with upstream and quality departments to ensure efficient process flow and product quality.
  • Maintain inventory of DSP consumables and request resupply as needed.
  • Become familiar with all required batch records, execute according to the batch records and ensure clear communication of the targeted design parameters.
  • Execute day-to-day Pilot Plant activities, coordinating equipment maintenance and installation activities, troubleshooting process upsets, troubleshooting equipment and instrumentation problems, optimizing operations, addressing contamination issues, addressing downtime or other runtime losses.
  • Maintain the upkeep of the Pilot Plant equipment through the process of initiating work notifications/work orders and maintenance scheduling; Be capable of correcting minor maintenance issues.
  • Adhere to company environmental, safety, and health policies and procedure. Ensure Pilot Plant compliance with safety and environmental regulations.
  • Physical demand requirements are more than sedentary work due to inspection of equipment. Must be able to climb stairs and ladders. Must be able to lift 50 pounds.

Working Hazards and Conditions:
This position involves work on the third floor of the facility and requires occasional manual handling of hazardous materials, including carrying pitchers of sulfuric acid and glassware (such as beakers, flasks, and similar lab equipment).
  • The role also involves working around hot steam tanks, requiring strict adherence to safety procedures and use of appropriate personal protective equipment (PPE) at all times.
  • At certain times, the employee may be required to work alone, necessitating compliance with Manus Bio's lone worker safety protocols to ensure proper communication and emergency preparedness.
  • Employees must maintain a heightened awareness of their surroundings, follow all established chemical handling and steam safety procedures, and participate in mandatory hazard and emergency response training.
  • Must be able to wear the required protective equipment, including respirators when needed.
  • Work schedule is considered shift but will vary depending on manufacturing plan and other extraordinary conditions.

Required Qualifications:
  • High school diploma or GED equivalent.
  • Minimum of 3 years downstream or related plant operator experience.
  • Must be able to follow minimal instructions and support safe work practices.
  • Must be an excellent team member with strong communication skills and a desire to work collaboratively.
  • Must be flexible with day-to-day duties and able to thrive in a start-up environment.
  • Must hold themselves to the highest professional and ethical standards.
  • Some familiarity with the production fermentation and downstream processes and equipment as well as microbiological and analytical laboratory procedures.
  • Demonstrates flexibility in job rotations/various assignments.
  • Basic PC skills which include Windows, Microsoft Office.

Preferred Qualification and Working Style:
  • SAP skills
  • Certified Train the Trainer skills
  • Delta V controls experience

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