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Downstream Processing Jobs in Texas (NOW HIRING)

Lonza

Scientist II, Downstream

Houston, TX · On-site

Scientist II, Downstream Location: This is an on-site position located in Pearland, TX. The purpose ... The ideal candidate will be responsible for leading new process development and improving existing ...

Lonza

Scientist II, Downstream

Houston, TX · On-site

Scientist II, Downstream Location: This is an on-site position located in Pearland, TX. The purpose ... The ideal candidate will be responsible for leading new process development and improving existing ...

Converge Resources

Engineering Manager

Houston, TX · On-site

... in downstream processing systems and operations support Proficiency with process simulation tools (e.g., ProMax or equivalent) Solid understanding of applicable industry standards (API, ASME, NFPA ...

Staffingine LLC

Drone Data Engineer

Houston, TX · On-site

$109K - $131K/yr

Enable downstream processing for * Computer vision models * Defect detection * Asset condition monitoring * Digital twin platforms * Work closely with data science teams to operationalize AI models ...

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How much do downstream processing jobs pay per hour?

As of Jul 9, 2026, the average hourly pay for downstream processing in Texas is $22.99, according to ZipRecruiter salary data. Most workers in this role earn between $18.37 and $26.20 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Processing position, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What is the best job in science stream?

The best job in the science stream depends on individual interests and skills, but roles such as research scientist, biomedical engineer, or data analyst are highly regarded. These positions often require relevant degrees, technical skills, and sometimes certifications, and they offer opportunities in research, healthcare, and technology sectors.

What are the typical daily responsibilities of someone working in Downstream Processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What is a Downstream Processing job?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What is a downstream technician?

A downstream technician is responsible for the purification and formulation of biopharmaceutical products after the initial production phase. They operate equipment such as chromatography systems and filtration units, following strict safety and quality protocols, often requiring knowledge of Good Manufacturing Practices (GMP).

What are the life science jobs?

Downstream processing jobs in the life sciences involve the purification and recovery of biological products such as proteins, vaccines, and antibodies. These roles typically require knowledge of bioprocessing techniques, laboratory skills, and familiarity with equipment like chromatography systems. Positions may include process technicians, bioprocess engineers, and quality control specialists working in manufacturing or research settings.

What is the role of a bioprocess engineer?

A bioprocess engineer designs, develops, and optimizes processes for producing biological products such as vaccines, therapeutics, and enzymes. They work with bioreactors, chromatography, and other downstream processing techniques to ensure efficient and scalable manufacturing, often requiring knowledge of biochemistry, engineering principles, and regulatory standards.
What are popular job titles related to Downstream Processing jobs in Texas? For Downstream Processing jobs in Texas, the most frequently searched job titles are:
What job categories do people searching Downstream Processing jobs in Texas look for? The top searched job categories for Downstream Processing jobs in Texas are:
Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Texas as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $47,811 per year, or $23 per hour.

Downstream Supervisor, Manufacturing

Velocity Bioworks

San Antonio, TX • On-site

Full-time

Re-posted 10 days ago

Job description

TITLE: Downstream Supervisor
REPORTS TO: Manager, Manufacturing
LOCATION: San Antonio, Texas (On-site)
The Company
Velocity Bioworks is a U.S.-based biopharma CDMO headquartered in San Antonio, Texas supporting funded programs as they move from development into manufacturing for clinical trials. We collaborate with sponsors who are past exploration and are ready to apply discipline, structure, and technical rigor to development, analytics, and manufacturing.
Velocity is built to accelerate speed to clinic through aligned execution. Our work focuses on translating defined program goals into scalable manufacturing processes and robust analytical strategies. These activities are designed to support near-term clinical timelines while meeting quality requirements. We operate where quality and execution directly influence clinical and business progress.
Position Summary
Reporting directly to the Manufacturing Manager, the Downstream Supervisor will be responsible for overseeing daily operations related to downstream processing in a CGMP-compliant biologics environment. An ideal candidate must have strong experience in downstream manufacturing, process execution, and the operation of qualified scaled equipment. Strong understanding of Good Manufacturing Practices (CGMP) and Regulatory Guidelines, strict attention to detail, high-quality customer service skills, sound judgment and ability to escalate issues appropriately, and the ability to work well and collaborate in cross-functional teams at Velocity Bioworks .
Key Responsibilities
Supervisory Role in Manufacturing Operations
  • Responsible for supervising daily manufacturing activities.
  • Responsible for setting manufacturing schedules and timelines and ensure adherence by manufacturing team.
  • Responsible for authoring and reviewing batch records and other CGMP documentation.
  • Accountable for time and resources management. Managing shift operations, prioritizing tasks, strategic resources allocation, delegating tasks effectively to assure schedule adherence.
  • Capable of motivating, coaching, and leading a team in a fast-paced, regulated environment. Leads by example, especially regarding GMP compliance and safety.
  • Responsible for hiring, onboarding, training, and performance evaluations.
  • Ensure team execution is logged in NetSuite program.
  • Ensure manufacturing execution is in compliance with equipment calibration and preventive maintenance.
  • Responsible for implementing continuous improvement methodologies. Encourages team suggestions for process improvement and error reduction.

Downstream Processing Expertise
  • Operate bench-scale to large-scale chromatography (AKTA) systems.
  • Operate bench-scale to large-scale filtration systems including tangential flow filtration (TFF) and depth filtration (DF).
  • Expert in Unicorn software for programming and control of chromatography (AKTA Pilot and AKTA Ready) and filtration (AKTA Ready Flux) systems.
  • Large-scale column packing and evaluation.
  • Single-use mixing and centrifugation systems (continuous and bucket)
  • Bulk fill and aseptic handling techniques
  • Filter use, handling, and filter integrity testing (FIT) with troubleshooting experience
  • Drive proactive troubleshooting among staff, encouraging equipment and processes SMEs development.

Documentation and Compliance
  • Maintain company and client confidentiality.
  • Responsible for meticulous and accurate review of executed production records for proper GDP and execution of production activities within established timelines.
  • Active collaboration with Change Controls, Risk Assessments, and Deviations Management, Investigation Tools (5 Why's, Fishbone Diagram, etc.) and CAPA Implementation in association with SMEs and QA team.
  • Communicate safety policies and goals and ensure team members adhere to facility safety policies.
  • Ability to track and interpret manufacturing performance data and use metrics to drive improvements.

Cross-functional Collaboration
  • Provide input and feedback to the Process Sciences/Technical Transfer team during development and scale-up.
  • Ability to coordinate activities with QA, QC, Process Sciences, Facilities, GMP Services, and Supply Chain teams.

Requirements
Education and Experience
Shall have education, training and experience, or any combination thereof.
  • Associate's, BS, MS, Ph.D. from an accredited college or university with major coursework in a Scientific or Engineering discipline preferred.
  • Ph.D. with 0-2 years, Master's with 4+ years, Bachelor's Degree with 6+ years or Associate's with 8+ years of experience within related discipline and track record of success.
  • Experience working in a GMP manufacturing environment is essential.
  • Manufacturing processes in downstream microbial systems is highly desirable.
  • Requires a strong background in CGMP and GDP principles and experience handling Quality Management Systems.

Knowledge and Skills
  • Must demonstrate proper writing and PC skills with a knowledge base in Microsoft Office Suite.
  • Must obtain a working knowledge of current global regulatory requirements and guidelines and perform within all Standard Operating Procedures (SOPs) and policies.
  • Must maintain a working knowledge of commercial and phase-appropriate cGMP's as they apply to various phases of clinical and commercial manufacturing.
  • Perform with accountability and integrity: Owns decisions and outcomes. Ability to take responsibility and "get the job done" in a high-energy, high-intensity, results-oriented environment.
  • Proven ability to communicate, engage and coordinate with external vendors and suppliers to ensure timely delivery of materials and services.
  • Communication skills: Excellent verbal and written communication skills; strong presentation skills as this role requires the ability to communicate and connect with all levels of the organization.
  • Strong listening skills to understand staff concerns or operational issues.
  • Critical and analytical thinking, good judgment and ethics, professional presence, interdepartmental collaboration, and demeanor.

Physical Requirements and Working Environment
  • Flexibility is required for working hours. Weekend work may be needed and earlier or later start/finish times may also be required.
  • The essential functions of the job are mostly performed in an environmentally controlled facility.
  • Job duties require a combination of office and cleanroom/ lab environments, and application of automated equipment with moderate noise levels.
  • Must meet gowning requirements for cleanroom Grade A/ISO 5 environments and pass PAPR physical requirements.
  • Job execution may require the employee to sit, stand up and walk during prolonged periods.
  • Reach with hands and arms and to talk and/or hear.
  • Lift and/or move up to 20 pounds may be part of the process tasks.
  • Vision acuity is required, including close vision, distance vision, color vision, and the ability to adjust focus.
  • Manual dexterity and manual ability to effectively use computer terminals are required.

Notice to Third Party Agencies: Velocity Bioworks does not accept unsolicited resumes from recruiters or employment agencies. In the event a recruiter or agency submits a resume or candidate without a previously signed agreement and approved engagement request with Velocity Bioworks, Velocity Bioworks reserves the right to pursue and hire those candidate(s) without any financial obligation to the recruiter or agency.
Velocity Bioworks is proud to be an EEO/AAP Employer. Velocity Bioworks encourages protected veterans, individuals with disabilities, and applicants from all backgrounds to apply. Velocity Bioworks ensures nondiscrimination in all programs and activities in accordance with Title VI of the Civil Rights Act.

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