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Downstream Processing Jobs Near Me

CAI

Validation Engineer

Columbus, OH · On-site

$72K - $80K/yr

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

CAI

Validation Engineer

Columbus, OH

$72K - $80K/yr

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

Bobbie

Processing Operator (2nd, 3rd Shift)

Heath, OH · On-site

$24/hr

If something is off here, everything downstream is affected. What you'll do every shift * Operate ... You've worked in food processing, pharma manufacturing, or another technical production environment ...

Bobbie

Processing Operator (2nd, 3rd Shift)

Heath, OH

$24/hr

If something is off here, everything downstream is affected. What you'll do every shift * Operate ... You've worked in food processing, pharma manufacturing, or another technical production environment ...

Bobbie

Processing Operator (2nd, 3rd Shift)

Heath, OH · On-site

$24/hr

If something is off here, everything downstream is affected. What you'll do every shift * Operate ... You've worked in food processing, pharma manufacturing, or another technical production environment ...

Duraco Inc.

Machine Operator (2nd Shift)

Lancaster, OH · On-site

$21/hr

Complete machine start-up and shut-down tasks, maintain accurate production reports and roll labels, and support inventory, shipping, or downstream processes. * Maintain a clean, orderly, and safe ...

PNC Bank

HR System Solution Architect--Varicent

Columbus, OH · On-site

$234K/yr

Review and validate inbound and outbound data, calculations, and reports to ensure accuracy, auditability, and consistency across payroll and downstream processes. Monitor and recommend improvements ...

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As of Jul 13, 2026, the average hourly pay for downstream processing in the United States is $24.67, according to ZipRecruiter salary data. Most workers in this role earn between $19.71 and $28.12 per hour, depending on experience, location, and employer.
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Downstream Processing jobs near you
A map of the United States highlighting the number of Downstream Processing job openings by state according to ZipRecruiter. The image is accompanied by a detailed chart listing the number of Downstream Processing job openings in each state, with California having the most at 2 and Hawaii the least at 0.
Senior GMP Technician, Downstream

Senior GMP Technician, Downstream

Forge Biologics

Columbus, OH • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 27 days ago

Job description

Forge Your Future with Us:
At Forge Biologics, we believe in turning bold ideas into life-changing realities. Our mission is simple yet powerful: to enable access to life-changing gene therapies and help bring them from ideas into reality. We partner with scientists, physicians, biotech and pharma innovators, and patient communities - all united by one goal: improving lives. If you're driven by purpose and excited to make a tangible impact, this is where your journey begins.
Our team works out of The Hearth, a state-of-the-art, 200,000-square-foot cGMP facility in Columbus, Ohio. Here, you won't just watch innovation happen - you'll be part of it. Whether you're scaling AAV manufacturing, collaborating on cutting-edge therapies, or supporting complex technical projects, you'll play a key role in bringing hope to patients with genetic diseases.
What sets Forge apart is our culture of H.O.P.E. We are hardworking, showing up each day with determination and grit. We are open, creating a space where ideas flow freely, and every voice is valued. We are purpose-driven, with every task directly tied to changing lives. And we are engaged, energized by the challenges we face and the milestones we achieve together.
At Forge, your growth matters. We're committed to helping you expand your skills, take on new challenges, and develop your career through mentorship, hands-on learning, and opportunities for advancement. Our people are our greatest investment, and we're proud to see team members grow with us.
If you're ready to use your talent to help deliver hope to patients around the world, join us - and be part of something bigger than yourself.
About The Role:
We are seeking an experienced and highly skilled individual to join our Downstream Manufacturing team. As a Senior Technician, GMP Manufacturing - Downstream you will play a pivotal role in the purification and processing of AAV-based gene therapy products in compliance with current Good Manufacturing Practices (cGMP) regulations. Your expertise in downstream bioprocessing and strong leadership abilities will contribute to the success of our manufacturing operations and the delivery of cutting-edge gene therapies that have the potential to transform the lives of patients.
Responsibilities:
  • Lead and execute downstream manufacturing operations, including but not limited to chromatography, filtration, ultrafiltration/diafiltration, and viral vector formulation steps, according to Standard Operating Procedures (SOPs) and batch records.
  • Independently prepare, operate, and troubleshoot advanced downstream equipment, such as chromatography systems, filtration systems, centrifuges, and tangential flow filtration (TFF) systems, ensuring optimal performance and compliance.
  • Monitor critical process parameters during manufacturing operation, analyze data, and proactively identify and address deviations or abnormalities, ensuring timely reporting and resolution.
  • Perform in-process testing and quality control checks, such as pH, conductivity, pressure measurements, and other analytical techniques to ensure product quality and compliance with specifications.
  • Lead and document all manufacturing activities, data, and results accurately and in compliance with cGMP regulations and company policies.
  • Collaborate closely with cross-functional teams, including Quality Assurance (QA) and Quality Control (QC), to investigate and resolve deviations, non-conformances, and quality incidents, ensuring compliance with regulations and meeting production timelines.
  • Drive process improvements by evaluating new technologies, equipment, and methods, and leading the implementation of strategies to enhance manufacturing efficiency, productivity, and compliance.
  • Mentor and train junior team members, providing guidance on process execution, troubleshooting, and adherence to cGMP guidelines.
  • Ensure the highest standards of safety procedures and environmental health and safety guidelines are followed, maintaining a safe working environment.
  • Stay updated with the latest advancements in gene therapy downstream manufacturing processes, regulatory requirements, and industry trends, and actively contribute to the continuous improvement of manufacturing practices.

Qualifications:
  • Bachelor's Degree (B.A. or B.S.) in Biology, Biochemistry, Biomedical Engineering or related life science field (or equivalent experience).
  • Prior experience working in a GxP or regulated environment.
  • Downstream processing or biologics manufacturing experience.
  • Extensive expertise and hands-on experience with downstream processing techniques and equipment, such as chromatography systems, filtration systems, centrifuges, and TFF systems.
  • Proficiency in conducting in-process testing and quality control checks to ensure product quality and compliance..
  • Excellent attention to detail and ability to accurately document and record experimental data and manufacturing activities.
  • Strong organizational skills and the ability to manage multiple tasks, prioritize effectively, and meet project timelines in a fast-paced environment.
  • Commitment to following SOPs, safety protocols, and regulatory guidelines to ensure compliance and product quality.
  • Demonstrated leadership abilities, including experience in mentoring and training junior team member.
  • Flexibility to work in shifts, including weekends and holidays, as required by manufacturing schedules.
  • Ability to stand for extended periods, and work in a cleanroom environment while wearing appropriate gowning and PPE.

Preferred Skills:
  • Basic understanding of viral vector-based gene therapy processes, principles, and quality requirements.

This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee. Duties, responsibilities and activities may change, or new ones may be assigned.
Work Environment and Physical Demands
Forge Biologics is an equal opportunity employer dedicated to building an inclusive and diverse workforce. Forge Biologics, provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.
We've Got You Covered:
At Forge Biologics, we believe our people deserve to be taken care of - in and out of the workplace. We've built a comprehensive compensation and benefits package designed to help you thrive, grow, and feel valued every step of the way:
Health from day one
  • Health, dental and vision insurance start your first day - with 90% of premiums covered for you and your family.

Time to recharge
  • A competitive paid time off plan - because rest fuels innovation.
  • 12 weeks of fully paid parental leave so you can focus on family when it matters most.

Rewarding your impact
  • Annual bonus opportunities for all full-time team members.
  • 401(k) with company match to help you plan for the future.
  • Special employee discounts, including childcare and dependent care savings.

Your wellness, supported
  • Onsite fitness facility at The Hearth.
  • Mental health counseling and financial planning services through our Employee Assistance Program.
  • Employer-paid short and long-term disability coverage to protect your peace of mind.

Fuel for your workday
  • A fully stocked kitchen with free snacks and beverages - we keep you energized and ready for what's next.

Grow with us
  • Ongoing professional development resources, training, and mentorship programs to help you build your care and grow within Forge.

Apply