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Downstream Processing Jobs in Raleigh, NC (NOW HIRING)

Novartis

Senior Manager, Process Engineering

Durham, NC

$114.10K - $211.90K/yr

Provide technical expertise on biologics process equipment across upstream and downstream manufacturing systems * Partner with Manufacturing Science and Technology, Operations, and Quality on process ...

Valspec

CQV Consultant

Holly Springs, NC

Downstream Processing * CIP (Clean-in-Place) Systems * PSE (Process Support Equipment) * Clean Utilities Key Responsibilities * Execute CQV lifecycle activities including commissioning, IQ/OQ, and ...

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How much do downstream processing jobs pay per hour?

As of May 31, 2026, the average hourly pay for downstream processing in Raleigh, NC is $23.98, according to ZipRecruiter salary data. Most workers in this role earn between $19.18 and $27.36 per hour, depending on experience, location, and employer.

What is a Downstream Processing job?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are the key skills and qualifications needed to thrive in the Downstream Processing position, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What are the typical daily responsibilities of someone working in Downstream Processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.
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Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Raleigh, NC as of May 2026, with employment types broken down into 1% As Needed, 84% Full Time, 8% Part Time, 1% Temporary, and 6% Contract. Highlights an 25% Physical, and 75% Remote job distribution, with an average salary of $49,886 per year, or $24 per hour.

Downstream Process Equipment Engineer

Technical Source

Holly Springs, NC

Contractor

Posted 25 days ago

Job description

Technical Source is currently in search of a Downstream Process Equipment Engineer for our pharmaceutical client in the Raleigh-Durham-Chapel Hill Area. This is a long-term contract position that requires on-site work. The qualified candidate should have experience supporting the start-up and commissioning of downstream process equipment.

Responsibilities of the Downstream Process Equipment Engineer include:

  • Provide Engineering Support to C&Q of Downstream Equipment
  • Troubleshoot Downstream Manufacturing Equipment
  • Initiate CAPA's and Change Controls
  • Lead Process Improvement Efforts

Qualifications of the Downstream Equipment Process Engineer include:

  • Bachelor's Degree in Engineering (Chemical Preferred)
  • 3+ Years of Experience in Process Engineering
  • Experience Working in a Greenfield Environment
  • Extensive Knowledge of Stainless Steel Downstream Equipment