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Downstream Processing Jobs in Raleigh, NC (NOW HIRING)

Astrix Inc

Manufacturing Associate

Cary, NC · On-site

The ideal candidate holds a BS degree and has hands-on expertise within both upstream and downstream processing. Key Responsibilities: * Operate and maintain bioreactors for cell culture and gene ...

Valspec

Validation Engineer

Holly Springs, NC · On-site

This role will focus on downstream process systems and requires strong hands-on field execution, system troubleshooting, and automation verification experience in a GMP-regulated environment. Key ...

Valspec

Validation Engineer (CQV)

Holly Springs, NC · On-site

This role will focus on downstream process systems and requires strong hands-on field execution, system troubleshooting, and automation verification experience in a GMP-regulated environment. Key ...

Valspec

Validation Engineer

Raleigh, NC

This role will focus on downstream process systems and requires strong hands-on field execution, system troubleshooting, and automation verification experience in a GMP-regulated environment. Key ...

Valspec

Validation Engineer (CQV)

Raleigh, NC · On-site

This role will focus on downstream process systems and requires strong hands-on field execution, system troubleshooting, and automation verification experience in a GMP-regulated environment. Key ...

Valspec

CQV Consultant

Holly Springs, NC

Downstream Processing * CIP (Clean-in-Place) Systems * PSE (Process Support Equipment) * Clean Utilities Key Responsibilities * Execute CQV lifecycle activities including commissioning, IQ/OQ, and ...

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Downstream Processing information

See Raleigh, NC salary details

$13

$23

$34

How much do downstream processing jobs pay per hour?

As of Jul 13, 2026, the average hourly pay for downstream processing in Raleigh, NC is $23.98, according to ZipRecruiter salary data. Most workers in this role earn between $19.18 and $27.36 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Processing position, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What is the best job in science stream?

The best job in the science stream depends on individual interests and skills, but roles such as research scientist, biomedical engineer, or data analyst are highly regarded. These positions often require relevant degrees, technical skills, and sometimes certifications, and they offer opportunities in research, healthcare, and technology sectors.

What are the typical daily responsibilities of someone working in Downstream Processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What is a Downstream Processing job?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What is a downstream technician?

A downstream technician is responsible for the purification and formulation of biopharmaceutical products after the initial production phase. They operate equipment such as chromatography systems and filtration units, following strict safety and quality protocols, often requiring knowledge of Good Manufacturing Practices (GMP).

What are the life science jobs?

Downstream processing jobs in the life sciences involve the purification and recovery of biological products such as proteins, vaccines, and antibodies. These roles typically require knowledge of bioprocessing techniques, laboratory skills, and familiarity with equipment like chromatography systems. Positions may include process technicians, bioprocess engineers, and quality control specialists working in manufacturing or research settings.

What is the role of a bioprocess engineer?

A bioprocess engineer designs, develops, and optimizes processes for producing biological products such as vaccines, therapeutics, and enzymes. They work with bioreactors, chromatography, and other downstream processing techniques to ensure efficient and scalable manufacturing, often requiring knowledge of biochemistry, engineering principles, and regulatory standards.
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Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Raleigh, NC as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $49,886 per year, or $24 per hour.
Process Development Associate Scientist

Process Development Associate Scientist

DSC Resources

Durham, NC • On-site

$90K - $100K/yr

Full-time

Posted 20 days ago

Job description

Process Development & Scale-Up Associate


No visa sponsorship | No third-party agencies


** Must be local to the Durham, NC area **


Seeking a motivated individual with experience in fermentation and downstream processing development and scale-up. This role reports to the Senior Director of Operations and sits within the supply chain and operations team. As the Process Development & Scale-Up Associate, you will support the technical development of new strains and help guide selected programs from bench-scale development to mature manufacturing at scale — sitting at the intersection of science and operations, with end-to-end visibility of product development and the opportunity to contribute directly to technical success across active scale-up programs. Alongside deep technical understanding, you will be expected to consider practical aspects of the business and support the operational excellence of the processes you develop.


Experience:

  • Bachelor's degree or higher in relevant field (life sciences, engineering)
  • 2–5 years of experience in industrial fermentation, biotechnology, or downstream processing
  • Experience with technical transfer documents and scale-up
  • Experience with live probiotic strains preferred
  • Experience with anaerobic strains preferred


Role:

  • Work with CDMOs and CMOs to develop processes for scaling novel strains in the probiotics industry
  • Help guide processes from proof-of-concept at bench scale to pilot and manufacturing scales
  • Conduct thorough research and contribute to the development of processes that meet the company's cost targets for commercialization of new technologies
  • Organize and maintain data records of all process development, both in-house and across partner facilities
  • Track and maintain timelines to ensure projects meet required deadlines
  • Travel to 3rd party facilities to support development and aid in commercialization efforts (25%)
  • Troubleshoot issues related to technology scale-up
  • Assist with various downstream applications including product formulation, stability, and shelf life
  • Contribute to development of downstream applications for freeze drying, spray drying, and cryopreservation


Salary - $90,000