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Downstream Processing Jobs in Raleigh, NC (NOW HIRING)

Astrix Inc

Manufacturing Associate

Cary, NC · On-site

The ideal candidate holds a BS degree and has hands-on expertise within both upstream and downstream processing. 6 month contract (potential of becoming permanent) Schedule M-F, 8am-4pm Key ...

Actalent

Senior Scientist

Raleigh, NC

$88K - $121K/yr

Strong experience in downstream processing, chromatography, purification, or bioprocessing applications. * Hands-on experience developing, validating, and applying analytical methods using HPLC and ...

New

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

Oversees and maintains the procedures, business processes and tools for downstream tech transfer. * Represents department in various technical and projects team meetings with client, board of health ...

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

Oversees and maintains the procedures, business processes and tools for downstream tech transfer. * Represents department in various technical and projects team meetings with client, board of health ...

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Downstream Processing information

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How much do downstream processing jobs pay per hour?

As of Aug 3, 2026, the average hourly pay for downstream processing in Raleigh, NC is $23.98, according to ZipRecruiter salary data. Most workers in this role earn between $19.18 and $27.36 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Processing position, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What is the best job in science stream?

The best job in the science stream depends on individual interests and skills, but roles such as research scientist, biomedical engineer, or data analyst are highly regarded. These positions often require relevant degrees, technical skills, and sometimes certifications, and they offer opportunities in research, healthcare, and technology sectors.

What are the typical daily responsibilities of someone working in Downstream Processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What is a Downstream Processing job?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What is a downstream technician?

A downstream technician is responsible for the purification and formulation of biopharmaceutical products after the initial production phase. They operate equipment such as chromatography systems and filtration units, following strict safety and quality protocols, often requiring knowledge of Good Manufacturing Practices (GMP).

What are the life science jobs?

Downstream processing jobs in the life sciences involve the purification and recovery of biological products such as proteins, vaccines, and antibodies. These roles typically require knowledge of bioprocessing techniques, laboratory skills, and familiarity with equipment like chromatography systems. Positions may include process technicians, bioprocess engineers, and quality control specialists working in manufacturing or research settings.

What is the role of a bioprocess engineer?

A bioprocess engineer designs, develops, and optimizes processes for producing biological products such as vaccines, therapeutics, and enzymes. They work with bioreactors, chromatography, and other downstream processing techniques to ensure efficient and scalable manufacturing, often requiring knowledge of biochemistry, engineering principles, and regulatory standards.
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What cities near Raleigh, NC are hiring for Downstream Processing jobs? Cities near Raleigh, NC with the most Downstream Processing job openings:
Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Raleigh, NC as of July 2026, with employment types broken down into 92% Full Time, 3% Part Time, and 5% Contract. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution, with an average salary of $49,886 per year, or $24 per hour.

Downstream Process Equipment Engineer

Technical Source

Holly Springs, NC

Contractor

Re-posted 29 days ago

Job description

Technical Source is currently in search of a Downstream Process Engineer for our pharmaceutical client in the Raleigh-Durham-Chapel Hill Area. This is a long-term contract position that requires on-site work. The qualified candidate should have experience supporting the start-up and commissioning of downstream process equipment.

Responsibilities of the Downstream Process Engineer include:

  • P&ID Walkdowns and Redlining
  • Provide Engineering Support to C&Q of Downstream Equipment
  • Troubleshoot Downstream Manufacturing Equipment
  • Interface with Vendors and Relevant Teams
  • Lead Process Improvement Efforts

Qualifications of the Downstream Process Engineer include:

  • Bachelor's Degree in Engineering (Chemical Preferred)
  • 3+ Years of Experience in Process Engineering
  • Experience Working in a Greenfield Environment
  • Extensive Knowledge of Stainless Steel Downstream Equipment

*No C2C or Sponsorship is available at this time*

*Compensation will scale based on experience and fit*