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Downstream Processing Jobs in Raleigh, NC (NOW HIRING)

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

Oversees and maintains the procedures, business processes and tools for downstream tech transfer. * Represents department in various technical and projects team meetings with client, board of health ...

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

$180 - $240/hr

Must have demonstrated biologics expertise in upstream or downstream processing and operations Must have experience in collaborating with process development, quality, supply chain, engineering and ...

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC

Oversees and maintains the procedures, business processes and tools for downstream tech transfer. * Represents department in various technical and projects team meetings with client, board of health ...

CAI

Validation Engineer

Raleigh, NC

$72K - $80K/yr

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

CAI

Validation Engineer

Raleigh, NC

$72K - $80K/yr

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

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Downstream Processing information

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How much do downstream processing jobs pay per hour?

As of Aug 24, 2026, the average hourly pay for downstream processing in Raleigh, NC is $23.98, according to ZipRecruiter salary data. Most workers in this role earn between $19.18 and $27.36 per hour, depending on experience, location, and employer.

What is downstream processing?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are the typical daily responsibilities of someone working in downstream processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What are the key skills and qualifications needed to thrive in downstream processing, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What does downstream processing involve?

Downstream processing involves the purification and recovery of products such as proteins, enzymes, or pharmaceuticals from bioreactors. It includes steps like filtration, chromatography, and concentration to ensure product quality and safety, often requiring knowledge of bioprocessing techniques and quality control standards.

What are popular job titles related to Downstream Processing jobs in Raleigh, NC?

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What job categories do people searching Downstream Processing jobs in Raleigh, NC look for?

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What cities near Raleigh, NC are hiring for Downstream Processing jobs?

Cities near Raleigh, NC with the most Downstream Processing job openings:

Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Raleigh, NC as of August 2026, with employment types broken down into 1% As Needed, 80% Full Time, 14% Part Time, 1% Temporary, 3% Contract, and 1% Nights. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $49,886 per year, or $24 per hour.

Specialist Manufacturing - Process Owner - Upstream / Downstream / Services

Amgen

Holly Springs, NC • On-site

Full-time

Re-posted 14 days ago

Job description

Career CategoryManufacturingJob Description

HOW MIGHT YOU DEFY IMAGINATION?

You'veworked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience,and passion to work toward your goals? At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over10 million patientsworldwide. Come do your bestworkalongside other innovative, driven professionals in this meaningful role.

Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the AmgenFleXBatch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. TheFleXBatch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.

Specialist Manufacturing - Process Owner - Upstream / Downstream / Services (Multiple Positions)

Live

What You Will Do

In this vital role, you will serve as a Process Owner within the Manufacturing Support organization atAmgenNorth Carolina (ANC). The Process Owner serves as a technical process steward and key interface between Manufacturing Operations and support organizations. This roleis responsible forsupporting manufacturing execution through technical process ownership, floor support, operational readiness activities, process governance, manufacturing change implementation support, and continuous improvement initiatives.

This position may support one of the following manufacturing areas depending on business needs and organizational assignment: Upstream Manufacturing, Downstream Manufacturing, or Manufacturing Services (Raw Material Dispensing and Solution Preparation).

  • Serve as the technical process owner for assigned manufacturing processes, equipment, and unit operations.

  • Provide manufacturing floor support, troubleshootingassistance, andhypercareduring routine manufacturing operations, process changes, startup activities, and first-time executions.

  • Support operational readiness activities including water runs, dry runs, equipment readiness verification, and Electronic Batch Record (EBR) testingsupport.

  • Partner with Manufacturing Operations to support reliable, compliant, and efficient manufacturing execution.

  • Monitor process performance andidentifyopportunities for process optimization, operational improvement, and risk reduction.

  • Support manufacturing-related change controls associated with process, equipment, procedural, and operational improvements.

  • Author, revise, review, andmaintainmanufacturing SOPs, forms, and other GMP documentation.

  • Ensure manufacturing processes are effectively translated into SOPs, manufacturing workflows, training materials, and associated digital manufacturing processes.

  • Provide technical input to manufacturing risk assessments and support identification and mitigation of process, equipment, procedural, and operational risks.

  • Participate in root cause analysis (RCA) activities and provide technical processexpertiseto support manufacturing investigations, major deviations, and quality events.

  • Support CAPA applicability assessments, CAPA implementation activities, and CAPA effectiveness checks.

  • Partner with Process Development to support process overviews, knowledge transfer activities, and facility fit assessments.

  • Partner with Supply Chain, Manufacturing, and Engineering to support material readiness and Bill of Material (BOM) alignment, including single-use assemblies and consumables.

  • Support MES and EBR activities by providing processexpertiseand manufacturing representation.

  • Participate ininspectionreadiness activities and support audits asrequired.

  • Appropriately escalate process, operational, quality, and compliance concerns.

Win

What We Expect of You

Basic Qualifications

  • Doctorate degree and 2 years of biotechnology operations experience OR

  • Master's degree in Engineering, Biology, Chemistry, Biochemistry, or related field and 4 years of biotechnology operations experience OR

  • Bachelor's degree and 6 years of biotechnology operations experience OR

  • Associate's degree and 10 years of biotechnology operations experience OR

  • High school diploma / GED and 12 years of biotechnology operations experience

Preferred Qualifications

  • Technicalexpertisein Upstream Manufacturing, Downstream Manufacturing, or Manufacturing Services (Raw Material Dispensing and Solution Preparation).

  • Strong technical knowledge of drug substance manufacturing processes, equipment, and unit operations.

  • Experience supporting GMP manufacturing operations in a biotechnology or pharmaceutical environment.

  • Experience supporting manufacturing floor operations, troubleshooting, andhypercareactivities.

  • Experience supporting operational readiness activities including water runs, dry runs, equipment testing, and startup support.

  • Experience authoring and maintaining GMP documentation including SOPs and manufacturing procedures.

  • Experience supporting manufacturing change controls and implementation activities.

  • Experienceparticipatingin risk assessments, root cause analyses, investigations, and CAPA implementation activities.

  • Experience supporting CAPA applicability assessments and effectiveness checks.

  • Experience supporting Manufacturing Execution Systems (MES) and Electronic Batch Records (EBRs) within a GMP manufacturing environment.

  • Knowledge of single-use technologies and Bill of Material (BOM) structures.

  • Strong technical writing, communication, problem-solving, and organizational skills.

Thrive

As we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being through comprehensive benefits, career development opportunities, and a collaborative culture.

.

Salary Range

107,545.40USD -145,502.60USD

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