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Downstream Processing Jobs in Raleigh, NC (NOW HIRING)

NCSU

BTEC Scientist

Raleigh, NC · On-site

We are looking for a self-driven Scientist who thrives in a collaborative team environment and is ready to lead laboratory work, instruct students, and master complex downstream processes. Your daily ...

CAI

Validation Engineer

Raleigh, NC · On-site

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

CAI

Validation Engineer

Raleigh, NC

$72.80K - $80.10K/yr

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

Amgen

Sr Engineer I - 2 Shift

Holly Springs, NC · On-site

$90.50K - $124.20K/yr

This role will develop domain expertise and system ownership to support process operations, focusing on Downstream Process engineering APPLICABLE SHIFTS AVAILABLE: - 2ndShift: 3pm to 11pm Monday ...

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$13

$23

$34

How much do downstream processing jobs pay per hour?

As of Jun 1, 2026, the average hourly pay for downstream processing in Raleigh, NC is $23.98, according to ZipRecruiter salary data. Most workers in this role earn between $19.18 and $27.36 per hour, depending on experience, location, and employer.

What is a Downstream Processing job?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are the key skills and qualifications needed to thrive in the Downstream Processing position, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What are the typical daily responsibilities of someone working in Downstream Processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.
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Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Raleigh, NC as of May 2026, with employment types broken down into 1% As Needed, 84% Full Time, 8% Part Time, 1% Temporary, and 6% Contract. Highlights an 25% Physical, and 75% Remote job distribution, with an average salary of $49,886 per year, or $24 per hour.
Downstream Bioprocess Engineer - Drug Substance Tech Transfer & Manufacturing Support (Biologics) (

Downstream Bioprocess Engineer - Drug Substance Tech Transfer & Manufacturing Support (Biologics) (

3 Key Consulting

Holly Springs, NC

$34 - $38/hr

Full-time

Posted 17 days ago

Job description

Job Title: Downstream Bioprocess Engineer – Drug Substance Tech Transfer & Manufacturing Support (Biologics)  (JP15229)
Location: Holly Springs, NC. 27540
Employment Type: Contract
Business Unit: Drug Substance
Duration: 1+ year with likely extensions and/or conversion to permanent
Posting Date: 4/14/2026
Pay Rate: $34 - $38/hour W2
Notes: Working Schedule: Dayshift with potential overtime
3 Key Consulting is hiring an Engineer for a consulting engagement with our direct client, a leading global biopharmaceutical company.
Job Details:
In this vital role you will be a part of the Process Development Drug Substance Technology group at FleX Batch Biologics Manufacturing Facility. This role will be immersed in all aspects of operations in a commercial bulk drug substance facility, which includes collaborating with other drug substance teams across our network.
Why is the Position Open?
Supplement additional workload on team.
Top Must Have Skills:
  • Manufacturing support
  • Downstream
  • Tech transfer

Day to Day Responsibilities:
  • Apply a fundamental understanding of Downstream bioprocessing to support biologics technology transfer, process validation, plant start-up, MFG troubleshooting and investigations
  • Support continuous process verification, process monitoring, optimization, complex investigation, and product life cycle management
  • Ensure safety and compliance of process development activities
  • Provide person-in-plant on floor process support as required
  • Provide support for regulatory filing, inspection, and other CMC activities

Basic Qualifications:
Master degree OR Bachelor degree and 2 years of experience OR Associate degree and 6 years of experience OR High school diploma / GED and 8 years of experience
Red Flags:
Not a team player
Interview process:
Phone with hiring manager, followed by virtual interviews with tech transfer team
We invite qualified candidates to send your resume to resumes@3keyconsulting.com.  If you decide that you’re not interested in pursuing this particular position, please feel free to take a look at the other positions on our website www.3keyconsulting.com/careers. You are also welcome to share this opportunity with anyone you think might be interested in applying for this role.