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Downstream Processing Jobs in Raleigh, NC (NOW HIRING)

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How much do downstream processing jobs pay per hour?

As of Sep 13, 2026, the average hourly pay for downstream processing in Raleigh, NC is $23.98, according to ZipRecruiter salary data. Most workers in this role earn between $19.18 and $27.36 per hour, depending on experience, location, and employer.

What is downstream processing?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are the typical daily responsibilities of someone working in downstream processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What are the key skills and qualifications needed to thrive in downstream processing, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What does downstream processing involve?

Downstream processing involves the purification and recovery of products such as proteins, enzymes, or pharmaceuticals from bioreactors. It includes steps like filtration, chromatography, and concentration to ensure product quality and safety, often requiring knowledge of bioprocessing techniques and quality control standards.

What are popular job titles related to Downstream Processing jobs in Raleigh, NC?

For Downstream Processing jobs in Raleigh, NC, the most frequently searched job titles are:

What job categories do people searching Downstream Processing jobs in Raleigh, NC look for?

The top searched job categories for Downstream Processing jobs in Raleigh, NC are:

Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Raleigh, NC as of September 2026, with employment types broken down into 1% As Needed, 74% Full Time, 17% Part Time, 1% Temporary, 6% Contract, and 1% Nights. Highlights an 86% Physical, 2% Hybrid, and 12% Remote job distribution, with an average salary of $49,886 per year, or $24 per hour.

Senior Engineer, Manufacturing Sciences

Durham, NC • On-site

KBI Biopharma, Inc.
Biotechnology Research and Development • 1 - 5K employees
Learn more about KBI Biopharma, Inc.external

$101K - $138K/yr

Full-time

Posted 13 days ago

KBI Biopharma rating

6.3

Company rating: 6.3 out of 10

Based on 7 frontline employees who took The Breakroom Quiz

Job description

Job Summary:
This role offers an exciting opportunity for a skilled engineer to impact the efficiency, quality, and innovation within downstream biologics processing at a KBI Biopharma. As the MS&T Senior Engineer - Downstream, you will be pivotal in supporting cGMP production operations through expertise in process engineering, technology transfer, and validation. Working closely with cross-functional teams and directly engaging with clients, you will lead the implementation of process improvements, troubleshoot technical issues, and ensure that client and regulatory standards are consistently met.
This position is ideal for an experienced engineer with a strong background in downstream processes and biologics, who thrives in a collaborative environment and is committed to driving excellence in manufacturing science and technology. The role offers opportunities for professional growth, exposure to cutting-edge technologies, and a dynamic work environment where your contributions will directly influence production success and client satisfaction.
Your Duties and Responsibilities
  • Technical Support and Process Ownership: Provide technical expertise for cGMP production runs, ensuring efficient and reliable downstream operations.Oversee and support the transfer of processes from development to manufacturing, including critical process descriptions and requirement definitions for site implementation.Develop and implement process validation, monitoring strategies, and documentation to ensure ongoing compliance and process stability.
  • Client Communication and Requirement Definition: Act as the primary point of contact for clients, managing communication to clearly articulate process requirements, expectations, and modifications.Facilitate client alignment on process design, transfer plans, and performance criteria, ensuring all production activities meet defined client standards.
  • Cross-Functional Collaboration and Team Leadership: Lead cross-functional teams to coordinate process implementation, validation, and optimization projects.Work closely with Manufacturing, Validation, QA, Facilities & Engineering, Supply Chain, IT, Automation, QC, and Process Development teams to ensure compliant, efficient process execution.Drive effective collaboration to align on process goals, solve complex challenges, and implement improvements.

Your Qualifications
  • Educational Background: Bachelor's degree in science or engineering with a minimum of 9 years of industry experience,OR Master's degree with at least 7 years of industry experience,OR PhD with at least 5 years of industry experience.
  • Skill and Competencies: Proven expertise in biologics, specifically in upstream or downstream processing, technical transfer, and operational support.Strong background in cGMP production operations is essential. Demonstrated experience in technical transfer and scale-up processes. Familiarity with process validation and GMP compliance requirements is highly preferred.Previous experience working in a cGMP manufacturing environment is an advantage.Detail-oriented and organized, with a strong commitment to quality and regulatory compliance.Team-oriented mindset with experience in leading projects and cross-functional initiatives.

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.
I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.
I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.

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