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Downstream Processing Jobs in Raleigh, NC (NOW HIRING)

Syngenta

Fermentation Scientist

Durham, NC · On-site

Proven hands-on experience in microbial fermentation (bacteria, fungi, or yeast) and downstream processing (e.g., centrifugation, filtration, freeze-drying). * Professional Experience: 2-3 years of ...

Syngenta Group

Fermentation Scientist

Durham, NC · On-site

Proven hands-on experience in microbial fermentation (bacteria, fungi, or yeast) and downstream processing (e.g., centrifugation, filtration, freeze-drying). * Professional Experience: 2-3 years of ...

CAI

Validation Engineer

Raleigh, NC

$72K - $80K/yr

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

NCSU

BTEC Scientist

Raleigh, NC

We are looking for a self-driven Scientist who thrives in a collaborative team environment and is ready to lead laboratory work, instruct students, and master complex downstream processes. Your daily ...

North Carolina State University

BTEC Scientist

Raleigh, NC · On-site

$63K - $88K/yr

We are looking for a self-driven Scientist who thrives in a collaborative team environment and is ready to lead laboratory work, instruct students, and master complex downstream processes. Your daily ...

CAI

Validation Engineer

Raleigh, NC

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

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Downstream Processing information

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How much do downstream processing jobs pay per hour?

As of Jun 22, 2026, the average hourly pay for downstream processing in Raleigh, NC is $23.98, according to ZipRecruiter salary data. Most workers in this role earn between $19.18 and $27.36 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Processing position, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What jobs pay $10,000 a month without a degree?

In downstream processing and related fields, high-paying roles such as process engineers, quality managers, or technical specialists can reach or exceed $10,000 per month with relevant experience and industry knowledge. These positions often require technical skills, certifications, or on-the-job training rather than a formal degree, especially in manufacturing, biotech, or pharmaceutical environments.

What is the role of downstream processing?

Downstream processing in a job context involves the purification, formulation, and packaging of products, such as biopharmaceuticals or chemicals, after initial production. It requires skills in chromatography, filtration, and aseptic techniques to ensure product quality and compliance with regulatory standards.

What is the highest paying biotech job?

In downstream processing, senior roles such as Director of Downstream Processing or Vice President of Bioprocessing tend to be the highest paying, often earning six-figure salaries. These positions require extensive experience, leadership skills, and expertise in bioprocessing techniques and regulatory compliance.

What is the highest paying job in food engineering?

In food engineering, senior roles such as Food Processing Plant Managers or Food Technology Directors tend to have the highest salaries, often exceeding six figures. These positions typically require extensive experience, advanced degrees, and strong leadership skills, with compensation influenced by company size and location.

What are the typical daily responsibilities of someone working in Downstream Processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What is a Downstream Processing job?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are popular job titles related to Downstream Processing jobs in Raleigh, NC? For Downstream Processing jobs in Raleigh, NC, the most frequently searched job titles are:
What job categories do people searching Downstream Processing jobs in Raleigh, NC look for? The top searched job categories for Downstream Processing jobs in Raleigh, NC are:
What cities near Raleigh, NC are hiring for Downstream Processing jobs? Cities near Raleigh, NC with the most Downstream Processing job openings:
Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Raleigh, NC as of June 2026, with employment types broken down into 1% As Needed, 84% Full Time, 14% Part Time, and 1% Nights. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $49,886 per year, or $24 per hour.
Manufacturing Sciences Engineer II

Manufacturing Sciences Engineer II

KBI Biopharma, Inc.

Durham, NC • On-site

$70K - $90K/yr

Full-time

Posted 8 days ago

Job description

JOB SUMMARY The Upstream MS&T Engineer II will apply sound scientific and engineering principles to successfully transfer and enroll new biopharmaceutical processes into the cGMP manufacturing facility. The scope of this role includes:
  • Leading technical transfer projects for platform and/or repeat clinical manufacturing programs
  • Supporting and/or driving business decisions and operations related to facility fit, time in plant and new technologies or equipment and communicating recommendations to the client
  • Performing facility fit activities including process flow diagram generation, scaleup calculations, defining equipment and solution requirements, and generation of bill of materials (BOM) and new item specifications
  • Providing technical support for cGMP production runs, CAPAs, process and product impact assessments for deviations and change controls
  • Providing supervisory and technical support for cGMP production runs, deviations and process/product impact assessments, change controls, and CAPAs
  • Providing supervisory and technical support during technical document execution, new equipment testing, water runs in manufacturing.
  • Compiling/Collecting and analyzing process data and communicating out to the client and upper management via production updates and campaign summary reports
  • Supporting/leading complex investigational and troubleshooting efforts and providing recommendations to manufacturing for implementation
  • Supporting/leading collaboration on strategic projects or studies with external partners (i.e. process development, vendors) and presents results in technical reports

JOB RESPONSIBILITIES The candidate should be able to apply engineering principles in-order to problem solve and drive projects to successful completion within defined timelines. The ability to manage multiple projects and resources is required. The candidate should have the ability to work independently and with teams. The candidate should also possess excellent communication skills.
MINIMUM REQUIREMENTS
  • BS in Science or Engineering with minimum of 4 years industry experience, Master's with 2 years industry experience or PhD with no years industry experience.
  • Expertise in upstream and/or downstream processing techniques and equipment in biologics
  • Experience with technical transfer and scale up is required
  • Experience with GMP compliance requirements
  • Working knowledge of Process Development and technical knowledge supporting IND development and early phase GMP production • Experience working in a cGMP manufacturing environment is preferred
  • Strong proficiency in English and overall communication is required
  • Strong engineering and scientific reasoning skills are required
  • Strong math skills are required
  • Position requires limited physical demands
  • Strong computers skills are required particularly in all MS Office programs
  • Some equipment operations and testing is required

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.
I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.
I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.

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