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Senior Scientist Downstream Process Development Jobs in Raleigh, NC

MedPharm

Sr. Process Engineer/Sr. Scientist

Durham, NC · On-site

$94K - $121K/yr

Job Summary The Sr. Process Engineer/Senior Scientist will lead late-stage development activities for topical and liquid oral pharmaceutical products, including process scale-up, technology transfer ...

MedPharm

Sr. Process Engineer/Sr. Scientist

Durham, NC · On-site

$94K - $121K/yr

Job Summary The Sr. Process Engineer/Senior Scientist will lead late-stage development activities for topical and liquid oral pharmaceutical products, including process scale-up, technology transfer ...

Berriehill Research

Senior Scientist

Raleigh, NC · On-site +1

$80K - $110K/yr

Process and interpret property insurance exposure data for input to HurLoss, ARA's hurricane ... Lead marketing/business development activities in one or more client areas. * Document work and ...

ARA

Senior Scientist

Raleigh, NC · On-site

$80K - $110K/yr

Process and interpret property insurance exposure data for input to HurLoss, ARA's hurricane ... Lead marketing/business development activities in one or more client areas. * Document work and ...

IQVIA

Senior Scientist

Durham, NC

$80K - $167K/yr

Collaborate with Discovery and Bioinformatics teams to guide R&D efforts related to antibody ... IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for ...

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

$180 - $240/hr

... Scientists and will collaborate with Process Development, Quality, Supply Chain, Facilities ... Must have demonstrated biologics expertise in upstream or downstream processing and operations Must ...

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

... Scientists and will collaborate with Process Development, Quality, Supply Chain, Facilities ... Oversees and maintains the procedures, business processes and tools for downstream tech transfer.

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

... Scientists and will collaborate with Process Development, Quality, Supply Chain, Facilities ... Oversees and maintains the procedures, business processes and tools for downstream tech transfer.

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Senior Scientist Downstream Process Development information

See Raleigh, NC salary details

$64.6K

$107.5K

$159.9K

How much do senior scientist downstream process development jobs pay per year?

As of Aug 23, 2026, the average yearly pay for senior scientist downstream process development in Raleigh, NC is $107,458.00, according to ZipRecruiter salary data. Most workers in this role earn between $88,900.00 and $121,500.00 per year, depending on experience, location, and employer.

What does a senior scientist in downstream process development do?

A Senior Scientist in Downstream Process Development focuses on developing, optimizing, and scaling up processes to purify biological products such as proteins or antibodies after cell culture (the 'downstream' part of biomanufacturing). They design experiments, analyze data, and work with cross-functional teams to ensure product quality and regulatory compliance. Their role is critical in moving biopharmaceutical products from research to commercial production by ensuring efficient and robust purification processes.

What are the key skills and qualifications needed to thrive as a senior scientist in downstream process development?

To thrive as a Senior Scientist in Downstream Process Development, you need advanced knowledge in bioprocess engineering, protein purification, and process scale-up, typically supported by a Ph.D. or Master’s degree in a relevant field. Expertise with chromatography systems (such as AKTA), analytical instrumentation, and familiarity with regulatory requirements like GMP are essential. Strong problem-solving abilities, leadership, and effective communication skills distinguish top performers in this role. These competencies are crucial for developing robust, scalable processes that meet quality standards and drive successful product development.

What are some common challenges faced by senior scientists in downstream process development, and how can they be addressed?

Senior Scientists in Downstream Process Development often encounter challenges such as optimizing purification processes for novel biologics, scaling up from lab to production scale, and ensuring product consistency and regulatory compliance. Addressing these challenges typically involves close collaboration with cross-functional teams, continuous process optimization, and staying current with industry advancements in chromatography and filtration technologies. Proactive problem-solving, effective communication, and leveraging data analytics are also key strategies for overcoming obstacles in this role.

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For Senior Scientist Downstream Process Development jobs in Raleigh, NC, the most frequently searched job titles are:

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Senior Scientist Downstream Process Development jobs near you
Infographic showing various Senior Scientist Downstream Process Development job openings in Raleigh, NC as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 14% Part Time, and 2% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $107,458 per year, or $51.7 per hour.

Process Development Associate II

KBI Biopharma, Inc.

Durham, NC • On-site

Full-time

Posted 19 days ago

KBI Biopharma rating

6.5

Company rating: 6.5 out of 10

Based on 6 frontline employees who took The Breakroom Quiz

Job description

Position Summary:
The Downstream Process Development Associate II supports and executes laboratory studies within the KBI Biopharma (KBI) Downstream Process Development organization under general supervision.
Position Responsibilities:
  • Conducts laboratory experiments in support of downstream/drug substance process development including preparing solutions, running downstream unit operations (chromatography, tangential flow filtration, clarification, normal filtration, etc.), sampling and executing basic analysis of process samples (concentration, pH, conductivity, etc.).
  • Exercises judgment within defined procedures and practices to determine appropriate action (sometimes called upon to exercise judgment outside of defined procedures).
  • Observes and analyzes data resulting from executed experiments; identifies and troubleshoots unexpected results with input and/or review from peers or management.
  • Compiles data and contributes to drafting of templated technical documents. May contribute to client presentation development and may interact with clients.
  • May contribute to the evaluation, development and implementation of new downstream technologies leading to process improvements and efficiency of operation in support of downstream process development and manufacturing activities.
  • Documents procedures, observations, and results in laboratory notebooks and responsible for maintaining training compliance, according to site expectation. Reviews documentation and records as assigned.
  • Contributes to general lab maintenance and operation excellence initiatives in accordance with internal guidance. Assures proper labeling, handling, and storage of all chemicals used in the area; assures proper labeling and disposition of hazardous waste in satellite areas; adheres to all safety requirements and follows safe procedures, and attends all required safety and health training, including handling hazardous waste.
  • Reacts to change productively and handles other essential tasks as assigned.

Minimum Requirements:
  • Process Development Associate II requires a B.S. degree and 2+ years experience or a M.S. degree.
  • Excellent written and verbal communication skills, focus on customer service, and ability to meet strict client deadlines. Flexibility of hours to support downstream processes. Knowledge of GMPs and biotechnology-derived product regulations preferred.

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.
I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.
I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.

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