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Senior Scientist Downstream Process Development Jobs in Raleigh, NC

IQVIA

Senior Scientist

Durham, NC

$80K - $167K/yr

Collaborate with Discovery and Bioinformatics teams to guide R&D efforts related to antibody ... IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for ...

Alcami Corporation

Sr. Scientist I - Bioassay

Durham, NC · On-site

$82K - $113K/yr

The Sr. Scientist I, Bioassay may also be required to work on method development and method validation projects. The Senior Scientist I, Bioassay will demonstrate strong knowledge in cell-based ...

Alcami Corporation

Sr. Scientist I - Bioassay

Durham, NC

$82K - $113K/yr

The Sr. Scientist I, Bioassay may also be required to work on method development and method validation projects. The Senior Scientist I, Bioassay will demonstrate strong knowledge in cell-based ...

Alcami Corporation

Sr. Scientist I - Bioassay

Durham, NC

$82K - $113K/yr

The Sr. Scientist I, Bioassay may also be required to work on method development and method validation projects. The Senior Scientist I, Bioassay will demonstrate strong knowledge in cell-based ...

BioFire Diagnostics

Sr. Scientist

Durham, NC

$83K - $106K/yr

Performs data collection, interprets, and draws conclusions to continue the development process ... Bachelor's degree required in Life Sciences (Microbiology, Biology, Biotechnology). * 2+ years of ...

bioMerieux

Sr. Scientist

Durham, NC · On-site

$83K - $106K/yr

Performs data collection, interprets, and draws conclusions to continue the development process ... Bachelor's degree required in Life Sciences (Microbiology, Biology, Biotechnology). * 2+ years of ...

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All JobsScientist Downstream Process Development JobsSenior Scientist Downstream Process Development JobsSenior Scientist Downstream Process Development Jobs in Raleigh, NC

Senior Scientist Downstream Process Development information

See Raleigh, NC salary details

$64.6K

$107.5K

$159.9K

How much do senior scientist downstream process development jobs pay per year?

As of Jul 13, 2026, the average yearly pay for senior scientist downstream process development in Raleigh, NC is $107,458.00, according to ZipRecruiter salary data. Most workers in this role earn between $88,900.00 and $121,500.00 per year, depending on experience, location, and employer.

What does a Senior Scientist in Downstream Process Development do?

A Senior Scientist in Downstream Process Development focuses on developing, optimizing, and scaling up processes to purify biological products such as proteins or antibodies after cell culture (the 'downstream' part of biomanufacturing). They design experiments, analyze data, and work with cross-functional teams to ensure product quality and regulatory compliance. Their role is critical in moving biopharmaceutical products from research to commercial production by ensuring efficient and robust purification processes.

What are the key skills and qualifications needed to thrive as a Senior Scientist in Downstream Process Development, and why are they important?

To thrive as a Senior Scientist in Downstream Process Development, you need advanced knowledge in bioprocess engineering, protein purification, and process scale-up, typically supported by a Ph.D. or Master’s degree in a relevant field. Expertise with chromatography systems (such as AKTA), analytical instrumentation, and familiarity with regulatory requirements like GMP are essential. Strong problem-solving abilities, leadership, and effective communication skills distinguish top performers in this role. These competencies are crucial for developing robust, scalable processes that meet quality standards and drive successful product development.

What are some common challenges faced by Senior Scientists in Downstream Process Development, and how can they be addressed?

Senior Scientists in Downstream Process Development often encounter challenges such as optimizing purification processes for novel biologics, scaling up from lab to production scale, and ensuring product consistency and regulatory compliance. Addressing these challenges typically involves close collaboration with cross-functional teams, continuous process optimization, and staying current with industry advancements in chromatography and filtration technologies. Proactive problem-solving, effective communication, and leveraging data analytics are also key strategies for overcoming obstacles in this role.
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Senior Scientist Downstream Process Development jobs near you
Process Development Associate Scientist

Process Development Associate Scientist

DSC Resources

Durham, NC

$90K - $100K/yr

Full-time

Posted 20 days ago

Job description

Process Development & Scale-Up Associate


No visa sponsorship | No third-party agencies


** Must be local to the Durham, NC area **


Seeking a motivated individual with experience in fermentation and downstream processing development and scale-up. This role reports to the Senior Director of Operations and sits within the supply chain and operations team. As the Process Development & Scale-Up Associate, you will support the technical development of new strains and help guide selected programs from bench-scale development to mature manufacturing at scale — sitting at the intersection of science and operations, with end-to-end visibility of product development and the opportunity to contribute directly to technical success across active scale-up programs. Alongside deep technical understanding, you will be expected to consider practical aspects of the business and support the operational excellence of the processes you develop.


Experience:

  • Bachelor's degree or higher in relevant field (life sciences, engineering)
  • 2–5 years of experience in industrial fermentation, biotechnology, or downstream processing
  • Experience with technical transfer documents and scale-up
  • Experience with live probiotic strains preferred
  • Experience with anaerobic strains preferred


Role:

  • Work with CDMOs and CMOs to develop processes for scaling novel strains in the probiotics industry
  • Help guide processes from proof-of-concept at bench scale to pilot and manufacturing scales
  • Conduct thorough research and contribute to the development of processes that meet the company's cost targets for commercialization of new technologies
  • Organize and maintain data records of all process development, both in-house and across partner facilities
  • Track and maintain timelines to ensure projects meet required deadlines
  • Travel to 3rd party facilities to support development and aid in commercialization efforts (25%)
  • Troubleshoot issues related to technology scale-up
  • Assist with various downstream applications including product formulation, stability, and shelf life
  • Contribute to development of downstream applications for freeze drying, spray drying, and cryopreservation


Salary - $90,000