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Senior Scientist Downstream Process Development Jobs in Raleigh, NC

Novartis

Senior Manager, Process Engineering

Durham, NC

$114.10K - $211.90K/yr

As a Senior Manager, Process Engineering, you will lead a team of engineers responsible for the ... and downstream manufacturing systems * Partner with Manufacturing Science and Technology ...

Amgen

Sr Engineer I - 2 Shift

Holly Springs, NC · On-site

$90.50K - $124.20K/yr

Our award-winning culture is collaborative, innovative, and science based. If you have a passion ... Manufacturing, Quality, Process Development, Maintenance, network partners) to ensure reliable ...

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$64.6K

$107.5K

$159.9K

How much do senior scientist downstream process development jobs pay per year?

As of May 30, 2026, the average yearly pay for senior scientist downstream process development in Raleigh, NC is $107,458.00, according to ZipRecruiter salary data. Most workers in this role earn between $88,900.00 and $121,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior Scientist in Downstream Process Development, and why are they important?

To thrive as a Senior Scientist in Downstream Process Development, you need advanced knowledge in bioprocess engineering, protein purification, and process scale-up, typically supported by a Ph.D. or Master’s degree in a relevant field. Expertise with chromatography systems (such as AKTA), analytical instrumentation, and familiarity with regulatory requirements like GMP are essential. Strong problem-solving abilities, leadership, and effective communication skills distinguish top performers in this role. These competencies are crucial for developing robust, scalable processes that meet quality standards and drive successful product development.

What are some common challenges faced by Senior Scientists in Downstream Process Development, and how can they be addressed?

Senior Scientists in Downstream Process Development often encounter challenges such as optimizing purification processes for novel biologics, scaling up from lab to production scale, and ensuring product consistency and regulatory compliance. Addressing these challenges typically involves close collaboration with cross-functional teams, continuous process optimization, and staying current with industry advancements in chromatography and filtration technologies. Proactive problem-solving, effective communication, and leveraging data analytics are also key strategies for overcoming obstacles in this role.

What does a Senior Scientist in Downstream Process Development do?

A Senior Scientist in Downstream Process Development focuses on developing, optimizing, and scaling up processes to purify biological products such as proteins or antibodies after cell culture (the 'downstream' part of biomanufacturing). They design experiments, analyze data, and work with cross-functional teams to ensure product quality and regulatory compliance. Their role is critical in moving biopharmaceutical products from research to commercial production by ensuring efficient and robust purification processes.
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What cities near Raleigh, NC are hiring for Senior Scientist Downstream Process Development jobs? Cities near Raleigh, NC with the most Senior Scientist Downstream Process Development job openings:
Senior Scientist Downstream Process Development jobs near you
Infographic showing various Senior Scientist Downstream Process Development job openings in Raleigh, NC as of May 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $107,458 per year, or $51.7 per hour.
Process Development Research Associate I/II - Downstream

Process Development Research Associate I/II - Downstream

KBI Biopharma, Inc.

Durham, NC

$55K - $75.90K/yr

Full-time

Posted 19 days ago

Job description

Position Summary

Responsible for supporting process development activities for downstream production processes, instruments and equipment.

Position Responsibilities

  • Support all downstream process development activities including execution of experiments, compilation and analysis of data and drafting of technical documents.

  • Assist in the evaluation, development and implementation of new downstream technologies leading to process improvements and efficiency of operation.

  • Assist with development of preliminary schedules along with material/personnel/equipment requirements to allow accurate and appropriate performance guarantees

  • Equipment troubleshooting and maintenance

  • General lab organization

Minimum Requirements

  • B.S. degree in biotechnology or related (or equivalent training) with 0-4 years experience or a M.S. degree with 0-2 years experience.

  • Research Associate II requires a B.S. degree and 2+ years experience or a M.S. degree.

  • Experience with downstream process development and chromatography equipment required. Excellent written and communication skills for customer service and ability to meet strict client deadlines. Flexibility of hours to support downstream processes. Knowledge of GMPs and biotechnology-derived product regulations preferred.

Salary:

Process Development Associate I: $55,000-$75,900

Process Development Associate II: $63,000-$86,900

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.

I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.

I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.

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