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Downstream Processing Jobs in Maryland (NOW HIRING)

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Downstream GMP Manufacturing Associate

Rockville, MD · On-site

$20 - $23.49/hr

Monitor processes using automated production systems and controls with supervision. * Obtain and perform in-process sampling. * Prepare buffers and solutions needed for Downstream activities ...

New

Buckeye Global IT Inc

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GMP MANUFACTURING ASSOCIATE - DOWNSTREAM

Rockville, MD · On-site

$22.50 - $23.50/hr

The Downstream GMP Manufacturing Associate will work as part of a team and work directly in ... Follow verbal and written procedures in operating production equipment and performing processing ...

New

Axle

Scientist

Gaithersburg, MD · On-site

Oversee the development of downstream processes for VRC clinical candidates and the process tech transfer to the VCMP for clinical material generation for the VRC - 1 * Provide project support to ...

Axle

Scientist

Gaithersburg, MD

Oversee the development of downstream processes for VRC clinical candidates and the process tech transfer to the VCMP for clinical material generation for the VRC - 1 * Provide project support to ...

Axle

Scientist

Gaithersburg, MD

Oversee the development of downstream processes for VRC clinical candidates and the process tech transfer to the VCMP for clinical material generation for the VRC -- 1 * Provide project support to ...

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How much do downstream processing jobs pay per hour?

As of Aug 9, 2026, the average hourly pay for downstream processing in Maryland is $23.95, according to ZipRecruiter salary data. Most workers in this role earn between $19.13 and $27.31 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in downstream processing, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

How does downstream processing work?

Downstream processing in a biological or pharmaceutical context involves the purification and recovery of target products, such as proteins or vaccines, from a complex mixture. It typically includes steps like filtration, chromatography, and concentration, often requiring specialized equipment and quality control measures. Downstream processing technicians need knowledge of bioprocessing techniques and safety protocols to ensure product purity and compliance with regulations.

What are the typical daily responsibilities of someone working in downstream processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What is downstream processing?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are popular job titles related to Downstream Processing jobs in Maryland? For Downstream Processing jobs in Maryland, the most frequently searched job titles are:
What job categories do people searching Downstream Processing jobs in Maryland look for? The top searched job categories for Downstream Processing jobs in Maryland are:
What cities in Maryland are hiring for Downstream Processing jobs? Cities in Maryland with the most Downstream Processing job openings:
Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Maryland as of August 2026, with employment types broken down into 80% Full Time, 15% Part Time, 1% Temporary, 3% Contract, and 1% Nights. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $49,807 per year, or $23.9 per hour.

Senior Downstream Bioprocess Engineer

Johns Hopkins Applied Physics Laboratory

Laurel, MD • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 6 days ago

Johns Hopkins Applied Physics Laboratory rating

9.6

Company rating: 9.6 out of 10

Based on 8 frontline employees who took The Breakroom Quiz

2nd of 73 rated research

Job description

Description
Do you enjoy developing downstream purification processes for microbial production of small molecules and metabolites?
Do you want to apply your expertise in in downstream bioprocess engineering to pressing national security challenges?
Do you enjoy working as part of an interdisciplinary team of scientists to solve complex biotechnology challenges?
If so, we're looking for someone like you to join our team in the Biological Sciences Group, here at the Johns Hopkins University Applied Physics Lab.
We are seeking a downstream bioprocess engineer to help us develop scalable purification processes for microbial biomanufacturing. You'll join an interdisciplinary team of microbiologists, metabolic engineers, and chemists working together to develop innovative biotechnology solutions for national security. As the team's downstream processing expert, you'll work closely with colleagues across multiple disciplines to recover, purify, and characterize microbially produced small molecules and metabolites.
As part of the Biological Sciences Group, in the Research Exploratory Development Department, you will be at the forefront of APL's mission to provide impactful contributions to critical challenges. You will contribute to building outstanding expertise in molecular biology, in the pursuit of challenges in national security.
As a Senior Downstream Bioprocess Engineer you will...
  • Develop and optimize downstream processes for recovery and purification of microbially produced small molecules and metabolites.
  • Design and execute experiments to improve process performance and characterize biomanufacturing products using analytical chemistry techniques.
  • Collaborate with interdisciplinary teams of scientists and engineers to develop innovative biotechnology solutions for national security applications.
  • Lead technical efforts on internally and externally funded research projects, including project planning, execution, and communication of results.
  • Contribute to the growth of our research portfolio by developing new technical concepts, writing proposals, and building relationships with sponsors and collaborators.

Qualifications
You meet our minimum qualifications for the job if you...
  • Have a PhD in Chemical Engineering, Biological Engineering, Biochemistry, Chemistry, or a related field
  • 1+ year of postdoctoral research experience.
  • Have experience developing downstream processing methods for microbial production of small molecules or metabolites.
  • Have experience developing and applying analytical chemistry methods, including HPLC, LC/MS, GC/MS, or related techniques.
  • Have experience designing, executing, and troubleshooting laboratory experiments for purification, characterization, and process optimization.
  • Have strong written and verbal communication skills, demonstrated through publications, presentations, or related experience.
  • Are able to obtain an Interim Secret level security clearance by your start date and can ultimately obtain a TS/SCI level clearance. If selected, you will be subject to a government security clearance investigation and must meet the requirements for access to classified information. Eligibility requirements include U.S. citizenship.

You'll go above and beyond our minimum requirements if you...
  • Have experience engineering microbial metabolic pathways or microbial strain development.
  • Have experience with yeast or non-model microorganisms.
  • Have experience scaling microbial bioprocesses from bench to pilot scale.
  • Have experience with molecular biology techniques used to support bioprocess development
  • Have experience leading multidisciplinary research projects or developing research proposals.

About Us
Why Work at APL?
The Johns Hopkins University Applied Physics Laboratory (APL) brings world-class expertise to our nation's most critical defense, security, space and science challenges. While we are dedicated to solving complex challenges and pioneering new technologies, what makes us truly outstanding is our culture. We offer a vibrant, welcoming atmosphere where you can bring your authentic self to work, continue to grow, and build strong connections with inspiring teammates.
At APL, we celebrate our differences of perspectives and encourage creativity and bold, new ideas. Our employees enjoy generous benefits, including a robust education assistance program, unparalleled retirement contributions, and a healthy work/life balance. APL's campus is located in the Baltimore-Washington metro area. Learn more about our career opportunities at https://www.jhuapl.edu/careers.
All qualified applicants will receive consideration for employment without regard to race, creed, color, religion, sex, gender identity or expression, sexual orientation, national origin, age, physical or mental disability, genetic information, veteran status, occupation, marital or familial status, political opinion, personal appearance, or any other characteristic protected by applicable law. APL is committed to providing reasonable accommodation to individuals of all abilities, including those with disabilities. If you require a reasonable accommodation to participate in any part of the hiring process, please contact Accessibility@jhuapl.edu.
The referenced pay range is based on JHU APL's good faith belief at the time of posting. Actual compensation may vary based on factors such as geographic location, work experience, market conditions, education/training and skill level with consideration for internal parity. For salaried employees scheduled to work less than 40 hours per week, annual salary will be prorated based on the number of hours worked. APL may offer bonuses or other forms of compensation per internal policy and/or contractual designation. Additional compensation may be provided in the form of a sign-on bonus, relocation benefits, locality allowance or discretionary payments for exceptional performance. APL provides eligible staff with a comprehensive benefits package including retirement plans, paid time off, medical, dental, vision, life insurance, short-term disability, long-term disability, flexible spending accounts, education assistance, and training and development. Applications are accepted on a rolling basis.
Minimum Rate
$105,000 Annually
Maximum Rate
$290,000 Annually

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