1

Downstream Processing Jobs in Maryland (NOW HIRING)

Design, implement, and support dataflow architectures that move information securely from front-end systems to back-end services and downstream processing environments. * Analyze interfaces, data ...

Production Technician

Frederick, MD · On-site

$17.25 - $21.50/hr

You will be operating downstream processing equipment according to established SOPs. This is your chance to be part of a team that's reimagining how we do things and creating a collective legacy.

Production Technician

Frederick, MD · On-site

$17.25 - $21.50/hr

You will be operating downstream processing equipment according to established SOPs. This is your chance to be part of a team that's reimagining how we do things and creating a collective legacy.

This position involves meticulously inspecting, sorting, and categorizing various types of waste and recyclable materials to optimize the efficiency of downstream processing and recycling operations.

This role ensures automation solutions are reliable, compliant, secure, and aligned with industry standards while supporting upstream and downstream process performance. The SME works closely with ...

Process Engineer -- Upstream / Downstream / Clean Utilities (Consultant) -- Contract Engagement: Valspec consultant placed onsite at a major biopharmaceutical manufacturing site in the Raleigh-Durham ...

Data Processing Developer

Columbia, MD · On-site

$150K - $200K/yr

Architect new data processing and presentation systems for downstream users. * Create custom automated data flows to make domain-specific data human-readable. * Integrate new data flows with existing ...

Automation SME

Gaithersburg, MD · On-site

$170K - $190K/yr

This role ensures automation solutions are reliable, compliant, secure, and aligned with industry standards while supporting upstream and downstream process performance. The SME works closely with ...

This role ensures automation solutions are reliable, compliant, secure, and aligned with industry standards while supporting upstream and downstream process performance. The SME works closely with ...

Sr. Data Scientist

Rockville, MD · On-site

$150K - $200K/yr

Analyze raw data: assessing quality, cleansing, structuring for downstream processing * Design accurate and scalable prediction algorithms * Collaborate with engineering team to bring analytical ...

Showing results 21-40

Downstream Processing information

See Maryland salary details

$13

$23

$34

How much do downstream processing jobs pay per hour?

As of Aug 9, 2026, the average hourly pay for downstream processing in Maryland is $23.95, according to ZipRecruiter salary data. Most workers in this role earn between $19.13 and $27.31 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in downstream processing, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

How does downstream processing work?

Downstream processing in a biological or pharmaceutical context involves the purification and recovery of target products, such as proteins or vaccines, from a complex mixture. It typically includes steps like filtration, chromatography, and concentration, often requiring specialized equipment and quality control measures. Downstream processing technicians need knowledge of bioprocessing techniques and safety protocols to ensure product purity and compliance with regulations.

What are the typical daily responsibilities of someone working in downstream processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What is downstream processing?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What cities in Maryland are hiring for Downstream Processing jobs? Cities in Maryland with the most Downstream Processing job openings:
Infographic showing various Downstream Processing job openings in Maryland as of August 2026, with employment types broken down into 80% Full Time, 15% Part Time, 1% Temporary, 3% Contract, and 1% Nights. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $49,807 per year, or $23.9 per hour.

DevSecOps / Sys Admin

Oak Leaf Solutions

Columbia, MD • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 11 days ago


Job description

DevSecOps / Systems AdministratorPosition SummaryTOP SECRET/SCI Clearance Required, with a CI POLY
SALARY RANGE:  $210 - 228K
LOCATION:  Columbia, MD

We are seeking an experienced DevSecOps / Systems Administrator to design, implement, secure, and maintain development and operational environments across cloud-based, on-premises, and air-gapped systems. This position will integrate security throughout the software development lifecycle, automate deployment and security processes, administer critical infrastructure, and support the secure movement and processing of data from front-end applications through back-end and downstream systems.

The ideal candidate will have broad technical expertise spanning DevSecOps, systems administration, cybersecurity, cloud infrastructure, server deployment, dataflow architecture, encryption, and compliance. This individual must be comfortable working across multidisciplinary teams and translating technical, security, operational, and customer requirements into reliable and secure solutions.

Key ResponsibilitiesDevSecOps and Security Integration
  • Integrate security controls, practices, and testing throughout the software development lifecycle.

  • Design, implement, and maintain secure CI/CD pipelines.

  • Automate application security testing, vulnerability scanning, compliance checks, and deployment processes.

  • Incorporate security tools into development, build, testing, and release workflows.

  • Conduct security assessments of new and existing systems, applications, and infrastructure.

  • Identify, prioritize, document, and support the remediation of security vulnerabilities.

  • Implement security frameworks, standards, policies, and industry best practices.

  • Monitor systems and infrastructure for security incidents, vulnerabilities, configuration issues, and emerging threats.

  • Develop technical solutions to satisfy system security and data-protection requirements.

  • Establish and publish DevSecOps procedures, technical standards, and security best practices.

Systems and Infrastructure Administration
  • Build, configure, secure, administer, and maintain physical and virtual servers.

  • Support cloud, on-premises, hybrid, and air-gapped computing environments.

  • Manage system configurations, operating systems, user access, permissions, patching, backups, and system availability.

  • Implement and maintain encryption for data at rest and in transit.

  • Monitor the health, performance, reliability, and security of networks, servers, applications, and supporting infrastructure.

  • Troubleshoot complex system, network, application, integration, and deployment issues.

  • Develop infrastructure-as-code solutions to create consistent, repeatable, and secure environments.

  • Support system hardening, configuration management, change management, and lifecycle maintenance.

  • Assist with the integration and administration of Cross Domain Solutions and other controlled data-transfer technologies, as applicable.

Dataflow and Systems Integration
  • Design, implement, and support dataflow architectures that move information securely from front-end systems to back-end services and downstream processing environments.

  • Analyze interfaces, data dependencies, processing requirements, and security boundaries across interconnected systems.

  • Support secure data exchanges among applications, networks, cloud environments, and external systems.

  • Work with software, hardware, and systems engineering teams to integrate system components and resolve technical dependencies.

  • Ensure data-handling solutions comply with applicable security, encryption, access-control, and operational requirements.

Compliance and Authorization Support
  • Support Authorization to Operate activities, including the preparation and maintenance of required security documentation.

  • Assist with security control implementation, assessment, evidence collection, remediation tracking, and audit preparation.

  • Develop and maintain system policies, procedures, diagrams, configuration records, and other technical documentation.

  • Work with cybersecurity, engineering, customer, and program stakeholders to address compliance requirements and authorization findings.

  • Ensure system configurations and operational practices remain consistent with applicable security frameworks and organizational policies.

Collaboration and Operational Support
  • Collaborate closely with software engineers, hardware engineers, systems engineers, cybersecurity personnel, customers, and support operations teams.

  • Provide technical guidance during system design, development, integration, testing, deployment, and operational implementation.

  • Promote shared responsibility for security across development, engineering, and operations teams.

  • Communicate technical risks, system requirements, vulnerabilities, and recommended solutions clearly to both technical and nontechnical stakeholders.

  • Support production deployments, system upgrades, incident response, troubleshooting, and operational transition activities.

  • Evaluate new technologies and recommend improvements to security, automation, scalability, reliability, and system performance.

Required Qualifications
  • Bachelor’s degree in computer science, engineering, information technology, cybersecurity, or a related field, or an equivalent combination of education and relevant experience.

  • At least five years of relevant experience in DevSecOps, systems administration, cloud engineering, cybersecurity engineering, infrastructure engineering, or a related technical field.

  • Strong understanding of DevOps and DevSecOps principles, secure software development practices, and the software development lifecycle.

  • Experience designing, implementing, or maintaining CI/CD pipelines.

  • Hands-on experience with infrastructure automation, configuration management, and version-control technologies.

  • Experience with tools such as:

    • Ansible

    • Jenkins

    • Terraform

    • Git and GitHub

    • GitHub Actions

    • Artifactory

    • Jira

    • Black Duck

    • Comparable DevSecOps, security, and automation platforms

  • Experience building, configuring, securing, and maintaining servers and supporting infrastructure.

  • Experience working in cloud-based, on-premises, hybrid, or air-gapped environments.

  • Knowledge of vulnerability management, secure configuration, access control, encryption, system hardening, and security monitoring.

  • Familiarity with information security frameworks, security controls, and compliance standards.

  • Experience developing technical documentation, operating procedures, security policies, or authorization materials.

  • Strong troubleshooting, analytical, organizational, and communication skills.

  • Demonstrated ability to work effectively across multiple technical disciplines and stakeholder groups.

Preferred Qualifications
  • Eight or more years of experience in DevSecOps, systems administration, cybersecurity, cloud infrastructure, or related roles.

  • Experience supporting highly regulated, government, defense, or other security-sensitive environments.

  • Experience with Authorization to Operate processes and security-control documentation.

  • Experience with Cross Domain Solutions or secure data-transfer systems.

  • Experience designing or supporting dataflow architectures from front-end applications through back-end and downstream processing systems.

  • Experience supporting disconnected, restricted, or air-gapped systems.

  • Knowledge of containerization, orchestration, artifact management, automated code scanning, and software supply-chain security.

  • Experience integrating static application security testing, dynamic application security testing, software-composition analysis, and infrastructure scanning into CI/CD pipelines.

  • Relevant technical or cybersecurity certifications.
    About Oak Leaf Solutions
    Founded in 2008, Oak Leaf Solutions is a mission-driven small business delivering advanced systems engineering, cybersecurity, and technical operations to U.S. Government customers. We specialize in high-impact work that supports national security, while cultivating a culture that values innovation, integrity, and employee well-being. At Oak Leaf, you’ll find a place where your skills make a difference—and where your compensation reflects your value. We offer highly competitive salaries, exceptional benefits, and meaningful opportunities for professional growth. Veterans, reservists, and cleared professionals are strongly encouraged to apply. Learn more at www.oakleafsolutions.net.
    What We Offer
    Our benefits are designed to take care of you—at work, at home, and everywhere in between:

  • Premium Medical Coverage
  • Tricare Supplement Plan – 100% employer-paid for employees, 80% for dependents
  • Dental & Vision Insurance – 100% employer-paid
  • Disability Insurance – 100% employer-paid
  • Life Insurance – $100,000 policy, 100% employer-paid
  • 401(k) with Company Contribution – Pre-tax or Roth, with up to $5,000/year in contributions
  • Generous Paid Leave – 15 PTO days + 11 federal holidays + up to 12 weeks parental leave
  • Professional Development – Up to $5,250/year for certifications, training, and education
  • Wellness Perks – Gym membership reimbursement (up to $50/month) + CareFirst Blue365 discounts
  • Support for Military Families – Pay differential for active duty reserve service
  • …and more.

Powered by JazzHR

vp3D3Jktq2