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Downstream Process Development Scientist Jobs in Maryland

Axle

Scientist

Gaithersburg, MD · On-site

Oversee the development of downstream processes for VRC clinical candidates and the process tech ... Mentors junior level scientists * Work closely with Project Managers to ensure downstream ...

Axle

Scientist

Gaithersburg, MD

Oversee the development of downstream processes for VRC clinical candidates and the process tech ... Mentors junior level scientists * Work closely with Project Managers to ensure downstream ...

Axle

Scientist

Gaithersburg, MD

Oversee the development of downstream processes for VRC clinical candidates and the process tech ... Mentors junior level scientists * Work closely with Project Managers to ensure downstream ...

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How much do downstream process development scientist jobs pay per hour?

As of Aug 8, 2026, the average hourly pay for downstream process development scientist in Maryland is $37.52, according to ZipRecruiter salary data. Most workers in this role earn between $27.55 and $44.81 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a downstream process development scientist?

To thrive as a Downstream Process Development Scientist, you need expertise in biochemistry, chemical engineering, and purification techniques, typically supported by a relevant science degree or higher. Experience with protein chromatography systems, filtration equipment, and data analysis software is highly valued, along with familiarity with GMP and regulatory requirements. Strong analytical thinking, problem-solving abilities, and effective teamwork and communication are key soft skills for this position. These competencies are crucial for optimizing manufacturing processes and ensuring the successful scale-up of biologic products in a collaborative environment.

What typical challenges might a downstream process development scientist encounter in their daily work?

Downstream Process Development Scientists often face challenges related to optimizing purification processes to achieve high yield and product purity, while maintaining efficiency and scalability. They may need to troubleshoot issues with chromatography, filtration, or product stability, sometimes under tight timelines. Working closely with cross-functional teams—including upstream development, quality control, and manufacturing—is common for resolving complex technical problems. Adaptability and continuous learning are important, as methods and equipment may evolve based on project needs and technological advancements.

What is a downstream process development scientist?

A Downstream Process Development Scientist is responsible for developing and optimizing processes to purify biological products, such as proteins, antibodies, or vaccines, after they are produced in upstream bioprocessing. They work with techniques like filtration, chromatography, and centrifugation to refine and scale up purification methods for manufacturing. Their role involves ensuring product quality, improving yields, and troubleshooting any processing challenges. Scientists in this field collaborate with cross-functional teams, including upstream development, analytical sciences, and manufacturing, to ensure efficient and scalable bioprocesses.

What are the most commonly searched types of Downstream Process Development Scientist jobs in Maryland? The most popular types of Downstream Process Development Scientist jobs in Maryland are:
What are popular job titles related to Downstream Process Development Scientist jobs in Maryland? For Downstream Process Development Scientist jobs in Maryland, the most frequently searched job titles are:
What job categories do people searching Downstream Process Development Scientist jobs in Maryland look for? The top searched job categories for Downstream Process Development Scientist jobs in Maryland are:
Downstream Process Development Scientist jobs near you
Infographic showing various Downstream Process Development Scientist job openings in Maryland as of August 2026, with employment types broken down into 87% Full Time, and 13% Contract. Highlights an 94% In-person, and 6% Hybrid job distribution, with an average salary of $78,051 per year, or $37.5 per hour.

Sr. Scientist (Downstream Process Development)

Kelly Services

Gaithersburg, MD • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 8 days ago

Job description

Kelly Government Solutions is a strategic supplier and business partner to the federal government and its key suppliers.  Through our partnership with the National Institutes of Health, Kelly Government Solutions offers administrative, IT, engineering, scientific, and healthcare professionals the opportunity to work with the leading medical research center in the world.  We have an opening for a Senior Scientist (Downstream Process Development) to work on-site at the National Institutes of Health (NIH) in Gaithersburg, MD.
This is a long-term contract position which offers:
-    Competitive compensation and comprehensive benefit package
-    Optional health, vision, and dental plans
-    Paid leave as well as 11 paid federal holidays and 401K plan.  
-    Access to NIH’s unparalleled resources and niche scientific initiatives
KEY TASKS
(1) Oversee the development of downstream processes for clinical candidates and the process of tech transfer for clinical material generation
(2) Provide project support to develop downstream process methods that meet the product quality and recovery characteristics to guarantee successful production of clinical material.
(3) Serve as a subject matter expert (SME) in guiding purification strategies for new vaccine or therapeutic mAb candidates 
(4) Work with regulatory team to support IND submissions and other requests. 
(5) Oversee viral clearance strategies in relevant downstream processes and direct the viral clearance validation efforts 
(6) Plan and oversee downstream processes for toxicology lot material production. 
(7) Coordinate with manufacturing teams to ensure timely and scale-appropriate Technology Transfer is achieved
(8) Write/edit/review tech transfer documents to support downstream process Master Batch Record authoring.
(9) Serve as SME in downstream troubleshooting and facility fit calculations. 
(10) Serve as the Center’s downstream SME in external collaborations for clinical development projects
(11) Work to troubleshoot and improve downstream methods during the development cycle. This includes efforts in designing optimization studies (DOE with JMP) and streamlining efforts to ensure timely development schedules
REQUIREMENTS
(1) Ph.D. in Bioengineering, Chemical Engineering, Biochemistry, or a related field
(2) Minimum of 8 years of relevant experience with recombinant protein purification development for GMP clinical-phase products
PLEASE APPLY ONLINE
When you apply, please know a Kelly Government Solutions Recruiter will review your resume and will contact you directly, if your skills and experience match the requirements of this position; a full job description can be made available at that time.
Due to the high volume of inquiries, we regret that we cannot accept phone calls. Even if you aren’t contacted for this position, you are still part of our talent network.  All Kelly recruiters have access to your profile, which expands your opportunities even further.
As part of our promise to talent, Kelly supports those who work with us through a variety of benefits, perks, and work-related resources. Kelly offers eligible employees voluntary benefit plans including medical, dental, vision, telemedicine, term life, whole life, accident insurance, critical illness, short-term disability, and a transportation spending account. In addition, this position offers employees the ability to earn up to 160 hours of paid time off annually and eleven paid holidays per benefit year. We also offer a generous defined 401(k) contribution to help you save for retirement. Visit https://www.mykelly.us/us-mykelly/perks/ for more information on benefits and perks that may be available to you as a member of the Kelly Talent Community.
#government
As part of our promise to talent, Kelly supports those who work with us through a variety of benefits, perks, and work-related resources. Kelly offers eligible employees voluntary benefit plans including medical, dental, vision, telemedicine, term life, whole life, accident insurance, critical illness, a legal plan, and short-term disability. As a Kelly employee, you will have access to a retirement savings plan, service bonus and holiday pay plans (earn up to eight paid holidays per benefit year), and a transit spending account. In addition, employees are entitled to earn paid sick leave under the applicable state or local plan. Click here for more information on benefits and perks that may be available to you as a member of the Kelly Talent Community.

Why Kelly® Government Solutions?

Looking to connect with premier government agencies or the top 25 federal government contractors? Kelly Government Solutions partners with these organizations to create expert talent solutions that solve the world’s most critical challenges. We offer a variety of full-time, project (SOW), seasonal, and surge support opportunities in science, engineering, technology, professional, and administrative support roles. Our experts will connect you to the opportunity that fits your schedule and interests and handle the details of transferring and processing all levels of security clearances. It’s just another way we make the job search work for you.

About Kelly

Work changes everything. And at Kelly, we’re obsessed with where it can take you. To us, it’s about more than simply accepting your next job opportunity. It’s the fuel that powers every next step of your life. It’s the ripple effect that changes and improves everything for your family, your community, and the world. Which is why, here at Kelly, we are dedicated to providing you with limitless opportunities to enrich your life-just ask the 300,000 people we employ each year.
Kelly is committed to providing equal employment opportunities to all qualified employees and applicants regardless of race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or any other legally protected status, and we take affirmative action to recruit, employ, and advance qualified individuals with disabilities and protected veterans in the workforce. Requests for accommodation related to our application process can be directed to the Kelly Human Resource Knowledge Center. Kelly complies with the requirements of California’s state and local Fair Chance laws. A conviction does not automatically bar individuals from employment. Kelly participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.
Kelly may use AI-powered tools during the recruitment and hiring process. For full details, including how Kelly uses AI, your rights, and how to request a reasonable accommodation, visit the Recruitment Artificial Intelligence Notice.

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