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Downstream Processing Jobs in Cary, NC (NOW HIRING)

Xsome Biotech

Downstream Development Scientist

Raleigh, NC · On-site

$90 - $130/hr

Execute experimental studies to support downstream process development and optimization in several units of operations (clarification, chromatography, and TFF) for manufacturing exosomes * Author ...

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Astrix Inc

Manufacturing Associate

Cary, NC · On-site

The ideal candidate holds a BS degree and has hands-on expertise within both upstream and downstream processing. 6 month contract (potential of becoming permanent) Schedule M-F, 8am-4pm Key ...

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Downstream Processing information

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How much do downstream processing jobs pay per hour?

As of Sep 2, 2026, the average hourly pay for downstream processing in Cary, NC is $22.86, according to ZipRecruiter salary data. Most workers in this role earn between $18.27 and $26.06 per hour, depending on experience, location, and employer.

What is downstream processing?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are the typical daily responsibilities of someone working in downstream processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What are the key skills and qualifications needed to thrive in downstream processing, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What does downstream processing involve?

Downstream processing involves the purification and recovery of products such as proteins, enzymes, or pharmaceuticals from bioreactors. It includes steps like filtration, chromatography, and concentration to ensure product quality and safety, often requiring knowledge of bioprocessing techniques and quality control standards.

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What cities near Cary, NC are hiring for Downstream Processing jobs?

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Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Cary, NC as of August 2026, with employment types broken down into 1% As Needed, 80% Full Time, 14% Part Time, 1% Temporary, 3% Contract, and 1% Nights. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $47,542 per year, or $22.9 per hour.

Downstream Process Engineer

Stark Pharma Solutions Inc

Raleigh, NC • On-site

Contractor

This job post has expired today. Applications are no longer accepted.

Job description

About the Company

Stark Pharma Solutions Inc. is a global consulting and staffing partner established in 2014, serving the Pharmaceutical, Medical Device, Biotech, and IT industries across the USA, Canada, and India.

We provide specialized consulting and staffing solutions across Quality & Validation, Regulatory Affairs, R&D, Manufacturing, Supply Chain, Project Management, and IT, with a focus on delivering tailored solutions that drive growth, operational excellence, and long-term client success.

Position: Downstream Process Engineer
Location: North Carolina
Duration: Long Term

Job Overview

We are looking for Downstream Process Engineers to support biopharmaceutical manufacturing operations. The role focuses on downstream processing, chromatography, process startup, troubleshooting, and manufacturing support.

Key Responsibilities

• Support downstream manufacturing operations.

• Support process startup and commissioning activities.

• Perform and support chromatography operations.

• Troubleshoot downstream process issues.

• Support process development and optimization.

• Prepare and review process documentation and batch records.

• Support technology transfer and scale-up activities.

• Work with Manufacturing, MSAT, Quality, Engineering, and Process Development teams.

• Support manufacturing readiness and startup activities.

• Follow GMP and quality requirements.

Required Qualifications

• Bachelor’s degree in Engineering, Biochemistry, Biotechnology, or a related field.

• Experience in pharmaceutical or biopharmaceutical manufacturing.

• Hands-on experience with chromatography.

• Experience with process or manufacturing startup activities.

• Experience working in a GMP environment.

• Strong troubleshooting and problem-solving skills.

• Good technical documentation and communication skills.

• Ability to work effectively with cross-functional teams.

How to Apply

Apply Now: Submit your updated resume to Stark Pharma Solutions Inc. for consideration.

Stark Pharma is an Equal Opportunity Employer and welcomes qualified candidates from diverse backgrounds.