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Downstream Processing Jobs in Pennsylvania (NOW HIRING)

Genesis10

Scientist - I (Assistant)

West Point, PA · On-site

$32.14/hr

This role involves supporting downstream processing of vaccine intermediates within a laboratory setting. The ideal candidate will prepare solutions, perform lab-scale experiments, and maintain ...

Merck & Co.

Associate Scientist/Engineer - Downstream Vaccines and Advanced Biotechnologies Process R&D - - Our company is a global health care leader with a diversified portfolio of prescription medicines ...

Valspec

Validation Engineer (CQV)

Collegeville, PA · On-site

This role will focus on downstream process systems and requires strong hands-on field execution, system troubleshooting, and automation verification experience in a GMP-regulated environment. Key ...

Valspec

CQV Consultant

Collegeville, PA

Downstream Processing * CIP (Clean-in-Place) Systems * PSE (Process Support Equipment) * Clean Utilities Key Responsibilities * Execute CQV lifecycle activities including commissioning, IQ/OQ, and ...

Valspec

CQV Consultant

Philadelphia, PA · On-site

Downstream Processing * CIP (Clean-in-Place) Systems * PSE (Process Support Equipment) * Clean Utilities Key Responsibilities * Execute CQV lifecycle activities including commissioning, IQ/OQ, and ...

AllSTEM Connections

Scientist - I (Assistant

West Point, PA · On-site

$64K - $66K/yr

Setup process equipment for lab-scale experiments • Prepare laboratory reagents, solutions and culture media • Perform lab-scale downstream processing of vaccine process intermediates • Perform ...

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How much do downstream processing jobs pay per hour?

As of Jul 27, 2026, the average hourly pay for downstream processing in Pennsylvania is $24.73, according to ZipRecruiter salary data. Most workers in this role earn between $19.76 and $28.17 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Processing position, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What is the best job in science stream?

The best job in the science stream depends on individual interests and skills, but roles such as research scientist, biomedical engineer, or data analyst are highly regarded. These positions often require relevant degrees, technical skills, and sometimes certifications, and they offer opportunities in research, healthcare, and technology sectors.

What are the typical daily responsibilities of someone working in Downstream Processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What is a Downstream Processing job?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What is a downstream technician?

A downstream technician is responsible for the purification and formulation of biopharmaceutical products after the initial production phase. They operate equipment such as chromatography systems and filtration units, following strict safety and quality protocols, often requiring knowledge of Good Manufacturing Practices (GMP).

What are the life science jobs?

Downstream processing jobs in the life sciences involve the purification and recovery of biological products such as proteins, vaccines, and antibodies. These roles typically require knowledge of bioprocessing techniques, laboratory skills, and familiarity with equipment like chromatography systems. Positions may include process technicians, bioprocess engineers, and quality control specialists working in manufacturing or research settings.

What is the role of a bioprocess engineer?

A bioprocess engineer designs, develops, and optimizes processes for producing biological products such as vaccines, therapeutics, and enzymes. They work with bioreactors, chromatography, and other downstream processing techniques to ensure efficient and scalable manufacturing, often requiring knowledge of biochemistry, engineering principles, and regulatory standards.
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Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in Pennsylvania as of July 2026, with employment types broken down into 2% Internship, 78% Full Time, 18% Contract, and 2% Nights. Highlights an 91% In-person, 2% Hybrid, and 7% Remote job distribution, with an average salary of $51,442 per year, or $24.7 per hour.

Principal Scientist, Viral Downstream Process Development

Dispatch Bio

Philadelphia, PA

Other

Posted 14 days ago

Job description

The role:

The Principal Scientist will serve as the downstream processing expert working closely with CDMOs to generate lentivirus and adenovirus products.  Reporting into the Senior Director of Process Development, this individual will also be responsible for building out the internal downstream purification capabilities within process development to support scale up and scale down.

Key responsibilities:

  • Oversee planning and execution of tech transfers, development and scale up of viral products being manufactured at CDMOs
  • Serve as the downstream subject matter expert on both internal and external (CDMO, equipment suppliers, etc.) teams
  • Build out internal downstream capabilities by identifying/procuring scale down models for process development
  • Design and execute studies to identify critical process parameters and optimize process setpoints across the clarification, Tangential Flow Filtration (TFF), chromatography and sterile filtration steps
  • Responsibility for execution, data review, analysis, and maintaining accurate and detailed lab notebooks
  • Author and review technical documents, including but not limited batch records, SOPs and development reports and process-specific sections of regulatory documents.
  • Represent the company externally at meetings (professional associations, with regulatory bodies, etc.)
  • Work cross-functionally with analytical development, research and development, program management to advance clinical programs

Required experience & skills: 

  • MS or Ph.D. in Chemical Engineering, Bioengineering or related discipline
  • Minimum of 10 years of experience with downstream purification process development in the biopharma industry
  • Experience directly managing a team
  • Technical experience with downstream unit operations including clarification, TFF, chromatography, sterile filtration and formulation
  • Experience with scale up and scale down of purification processes
  • An understanding of cGMP and regulatory requirements for biopharmaceuticals
  • Strong organizational & problem-solving skills, with the proven ability to collaborate in a dynamic team environment
  • Strong scientific reasoning, problem-solving, and applied statistics skills, including the ability to break down complex problems into manageable hypotheses
  • Proficiency in using Microsoft Word, Excel, Power Point and data analysis/presentation software such as JMP and/or GraphPad
  • Excellent interpersonal, verbal and written communication skills.
  • Excellent organizational and planning skills, strong work ethic and the desire to work in a flexible and fast-paced, entrepreneurial environment

Preferred experience & skills: 

  • Experience with Quality by Design (QbD) approach to drug development including risk assessments, Design of Experiments (DoE) and statistical methods
  • Experience drafting CMC sections for INDs
  • Experience with technology transfers to external manufacturing facilities

 

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