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Downstream Processing Jobs in North Carolina (NOW HIRING)

Astrix Inc

Manufacturing Associate

Cary, NC · On-site

The ideal candidate holds a BS degree and has hands-on expertise within both upstream and downstream processing. 6 month contract (potential of becoming permanent) Schedule M-F, 8am-4pm Key ...

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How much do downstream processing jobs pay per hour?

As of Aug 23, 2026, the average hourly pay for downstream processing in North Carolina is $22.42, according to ZipRecruiter salary data. Most workers in this role earn between $17.93 and $25.58 per hour, depending on experience, location, and employer.

What is downstream processing?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are the typical daily responsibilities of someone working in downstream processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What are the key skills and qualifications needed to thrive in downstream processing, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What does downstream processing involve?

Downstream processing involves the purification and recovery of products such as proteins, enzymes, or pharmaceuticals from bioreactors. It includes steps like filtration, chromatography, and concentration to ensure product quality and safety, often requiring knowledge of bioprocessing techniques and quality control standards.

What are the most commonly searched types of Downstream Processing jobs in North Carolina?

The most popular types of Downstream Processing jobs in North Carolina are:

What are popular job titles related to Downstream Processing jobs in North Carolina?

For Downstream Processing jobs in North Carolina, the most frequently searched job titles are:

What job categories do people searching Downstream Processing jobs in North Carolina look for?

The top searched job categories for Downstream Processing jobs in North Carolina are:

What cities in North Carolina are hiring for Downstream Processing jobs?

Cities in North Carolina with the most Downstream Processing job openings:

Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in North Carolina as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 11% Part Time, 7% Temporary, 2% Contract, and 1% Nights. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $46,639 per year, or $22.4 per hour.

Downstream Process Equipment Engineer

Technical Source

Holly Springs, NC • On-site

Contractor

Re-posted 19 days ago

Job description

Technical Source is currently in search of a Downstream Process Engineer for our pharmaceutical client in the Raleigh-Durham-Chapel Hill Area. This is a long-term contract position that requires on-site work. The qualified candidate should have experience supporting the start-up and commissioning of downstream process equipment.

Responsibilities of the Downstream Process Engineer include:

  • P&ID Walkdowns and Redlining
  • Provide Engineering Support to C&Q of Downstream Equipment
  • Troubleshoot Downstream Manufacturing Equipment
  • Interface with Vendors and Relevant Teams
  • Lead Process Improvement Efforts

Qualifications of the Downstream Process Engineer include:

  • Bachelor's Degree in Engineering (Chemical Preferred)
  • 3+ Years of Experience in Process Engineering
  • Experience Working in a Greenfield Environment
  • Extensive Knowledge of Stainless Steel Downstream Equipment

*No C2C or Sponsorship is available at this time*

*Compensation will scale based on experience and fit*