Stoke Jobs (NOW HIRING)

About Stoke:
Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke's initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke's proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/
Position Purpose:
The Director/Senior Director, Medical Affairs Analytics & Systems will lead the systems, data, and analytics capabilities that enable Medical Affairs to operate efficiently and support timely, data-informed decision-making.
Serving as the primary Medical Affairs partner to IT and Commercial Operations, this individual will translate Medical Affairs needs into clear business requirements, integrated workflows, and scalable technology solutions. They will connect information across Field Medical, Medical Information, Scientific Communications, publications, congresses, advisory boards, and other activities-making it easier to identify patterns, access relevant information, and apply insights to strategic decisions.
This role will own the Medical Affairs systems and analytics roadmap, including platform integration, reporting automation, data governance, adoption, and responsible AI enablement. Success will require technical fluency to work credibly with IT and vendors, combined with a strong understanding of Medical Affairs objectives, workflows, and compliance requirements.
This position will report to the Executive Director, Scientific Communications & Information.
Key Responsibilities
Medical Affairs Ecosystem and Systems

• Own and execute the roadmap for an integrated, best-in-class Medical Affairs ecosystem.
• Translate Medical Affairs needs into clear requirements, streamlined workflows, and implementation priorities.
• Represent Medical Affairs in enterprise systems and data discussions, partnering with IT and Commercial Operations to improve connectivity while reducing fragmentation, duplication, and unnecessary complexity.
• Lead the implementation, integration, governance, and optimization of selected Medical Affairs platforms and manage associated vendors.
• Maintain accountability for roadmap delivery, including priorities, budgets, timelines, dependencies, risks, vendor performance, and leadership communication.
• Drive adoption, training, and continuous improvement, ensuring solutions remain practical, scalable, and aligned with Medical Affairs, compliance, and enterprise requirements.

Analytics and Reporting

• Lead the development of Medical Affairs dashboards and reporting capabilities through internal and external partners.
• Partner with Medical Affairs leadership to establish meaningful KPIs and reporting frameworks.
• Connect data across Medical Affairs activities and establish appropriate standards for data quality, consistency, and access.
• Advance scalable analytics capabilities that reduce manual effort, identify trends over time, and support more timely, informed decision-making.
• Translate business questions into analytical requirements and ensure outputs are clear, relevant, and decision-ready.

AI Enablement and Innovation

• Lead the implementation of AI-enabled capabilities that support Medical Affairs priorities, including medical intelligence, reporting, knowledge retrieval, content management, and field enablement.
• Identify opportunities for AI and automation to simplify workflows, improve access to information, and reduce administrative burden.
• Integrate AI capabilities into existing systems and ways of working, avoiding additional disconnected tools and processes.
• Establish appropriate governance, human oversight, success measures, and adoption plans.
• Partner with IT, Legal, Privacy, Regulatory, Compliance, and vendors to implement AI responsibly and effectively.

Required Skills & Experience

• Bachelor's degree in a relevant scientific, business, technology, or healthcare discipline, or equivalent experience
• 10+ years of relevant biotech/pharma experience, including at least five years focused on Medical Affairs systems, analytics, operations, or digital capabilities
• Experience operating in a small, clinical-stage or pre-commercial rare-disease biotechnology company, with the ability to lead strategically while directly driving execution.
• Strong understanding of Medical Affairs objectives, workflows, data, and compliance requirements
• Demonstrated experience translating Medical Affairs needs into integrated systems and analytics solutions and leading implementation through adoption and optimization
• Technical fluency across data integration, analytics, automation, and AI, with the ability to direct vendors and influence IT, Commercial Operations, and senior stakeholders without direct authority

Preferred Skills & Experience

• Advanced degree in a relevant scientific, business, technology, or healthcare discipline
• Experience building or substantially evolving an integrated Medical Affairs systems and analytics ecosystem

Location(s):
This is a hybrid/remote position, with a strong preference for candidates based in the Eastern United States to facilitate regular travel to Stoke's Massachusetts offices. Stoke is currently located in Bedford, MA, and will move to Waltham, MA, by the end of 2026.
Travel:
This position will require approximately 10% travel, primarily for team, vendor or industry meetings.
Compensation & Benefits:
At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.
The anticipated salary range for this role at the Director level is $180,000 - $253,000 and at the Sr. Director level is $229,000 - $302,000.The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.
Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).
Culture & Values:
At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.
Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.
Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center:
https://www.stoketherapeutics.com/careers/
For more information, visit https://www.stoketherapeutics.com/.
All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.
Stoke participates in E-Verify.