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Operational Readiness Manager Jobs in Raleigh, NC

First Citizens Bank

Senior Manager IT

Raleigh, NC · On-site +1

Support technology upgrades, platform lifecycle management, and operational readiness for new solutions. * Manage relationships with telecommunications carriers and strategic technology vendors.

First Citizens Bank

Senior Manager IT

Raleigh, NC · On-site +1

Support technology upgrades, platform lifecycle management, and operational readiness for new solutions. * Manage relationships with telecommunications carriers and strategic technology vendors.

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Operational Readiness Manager information

What is an operational readiness manager?

An Operational Readiness Manager is responsible for ensuring that a company’s people, processes, and systems are fully prepared for the launch or transition of new projects, systems, or facilities. They coordinate between various departments to identify potential risks, develop readiness plans, and implement solutions to ensure smooth operations from day one. Their role often involves change management, training, and testing to confirm that all operational requirements are met prior to go-live. This position is crucial in industries such as construction, IT, energy, and manufacturing, where seamless transitions are critical for business continuity.

How does an operational readiness manager collaborate with cross-functional teams during project rollouts?

Operational Readiness Managers work closely with departments such as engineering, IT, HR, and operations to ensure all aspects of a project are ready for launch. They facilitate regular meetings, coordinate readiness assessments, and align stakeholders on deliverables and timelines. This role often serves as a bridge between technical teams and business units, ensuring seamless communication and that potential risks or gaps are addressed early. Effective collaboration helps ensure a smooth transition from project phase to operational use, minimizing disruptions.

What are the key skills and qualifications needed to thrive as an operational readiness manager, and why are they important?

To excel as an Operational Readiness Manager, you need expertise in project management, risk assessment, process improvement, and a relevant bachelor's degree, often in business, engineering, or a related field. Familiarity with project management tools (like MS Project or Primavera), readiness assessment frameworks, and sometimes certifications such as PMP are typically required. Strong leadership, problem-solving, and communication skills help you coordinate cross-functional teams and manage complex transitions. These skills ensure seamless project launches, minimize operational disruptions, and drive continual organizational improvement.

What is the difference between Operational Readiness Manager vs Project Manager?

AspectOperational Readiness ManagerProject Manager
Primary FocusEnsuring operational systems and processes are prepared for launch or changePlanning, executing, and closing projects within scope, time, and budget
CertificationsCertifications like PMP, Six Sigma often preferredProject Management Professional (PMP), PRINCE2
Work EnvironmentOperations teams, cross-departmental coordinationProject teams, stakeholders, clients
Industry UsageCommon in industries with complex operational setups like manufacturing, energyWidely used across various industries for project execution

While both roles require strong project management skills and certifications, the Operational Readiness Manager focuses on preparing operational systems for deployment, whereas the Project Manager oversees the entire project lifecycle. Understanding these differences helps organizations assign the right responsibilities and find suitable candidates.

What are popular job titles related to Operational Readiness Manager jobs in Raleigh, NC?

For Operational Readiness Manager jobs in Raleigh, NC, the most frequently searched job titles are:

What job categories do people searching Operational Readiness Manager jobs in Raleigh, NC look for?

The top searched job categories for Operational Readiness Manager jobs in Raleigh, NC are:

What cities near Raleigh, NC are hiring for Operational Readiness Manager jobs?

Cities near Raleigh, NC with the most Operational Readiness Manager job openings:

Operational Readiness Manager jobs near you
Infographic showing various Operational Readiness Manager job openings in Raleigh, NC as of August 2026, with employment types broken down into 88% Full Time, and 12% Contract. Highlights an 70% In-person, 15% Hybrid, and 15% Remote job distribution.

Front Line Manufacturing Manager - Upstream Bulk Drug Substance - Days

Initial Therapeutics, Inc.

Holly Springs, NC • On-site

$100 - $150/hr

Other

Medical, Dental, Vision, Life, Retirement

Posted 4 days ago

Job description

Front Line Manufacturing Manager - Upstream Bulk Drug Substance - Days

Join Amgens Mission of Serving Patients

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission to serve patients living with serious illnesses drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

What you will do

Amgen is seeking a Manager Manufacturing Upstream to provide frontline leadership supporting the facility expansion program and facility startup. This essential role will lead a team responsible for manufacturing cell culture operations including seed train, SUBs, Perfusion, RTF, Stainless Steel BRXs, Depth Filtration and Centrifugation, while partnering across functions to ensure successful operational readiness, technology transfer, and rampup of manufacturing operations within the new facility.

The Manager will play a critical role supporting the design, build, startup, and operational phases of the facility expansion. The position will initially focus on facility startup and operational readiness activities, transitioning to manufacturing leadership as the facility becomes operational. During this phase of the startup, you will be expected to work a Monday Friday schedule from 8am to 5pm. This role may require work outside standard business hours, including nonstandard shifts, as needed to support startup, commissioning and qualification (C&Q), and engineering execution.

As the business moves from C&Q to manufacturing operations, this essential position will work on a 12-hour 2-2-3 schedule from 5:45am to 6:15pm supporting our critical 24/7 manufacturing operations. As Amgen relies upon the regular attendance of all staff members to meet legitimate business needs, the Manager must be able to work assigned 12‑hour shift, including during inclement weather, some holidays and requested overtime in support of our operations.

Responsibilities
  • Frontline Leadership: Lead, develop, and coach a manufacturing team; set clear performance expectations; foster a strong culture of safety, quality, and accountability.
  • Facility Startup & Operational Readiness: Support design, build, commissioning, qualification (C&Q), staffing, training, and readiness milestones for a new manufacturing facility.
  • Manufacturing Operations: Ensure safe, cGMP‑compliant execution; drive performance across safety, quality, schedule, and cost; resolve deviations and operational issues.
  • Technology Transfer & Process Implementation: Support transfer and implementation of manufacturing processes; ensure manufacturability, troubleshooting, and continuous improvement.
  • Cross‑Functional Collaboration: Partner with Quality, Engineering, NPI, Supply Chain, Validation, and Site Leadership to enable successful startup and ramp‑up.
  • Compliance & Inspection Readiness: Maintain inspection readiness and adherence to regulatory and Amgen quality standards.
  • Continuous Improvement: Identify and drive efficiency, reliability, and scalability improvements as operations mature.
  • Shift Support: Work nonstandard hours as required, transitioning to a 12‑hour 2‑2‑3 day shift supporting 24/7 operations.
What we expect from you

We seek a manager who brings strong leadership, performance management, and conflict resolution skills, and who can lead people, projects, programs and resource allocation in a manufacturing environment.

Basic Qualifications
  • Doctorate degree OR
  • Masters degree and 3 years of Manufacturing or Operations experience OR
  • Bachelor's degree and 5 years of Manufacturing or Operations experience OR
  • Associate's degree and 10 years of Manufacturing or Operations experience OR
  • High school diploma / GED and 12 years of Manufacturing or Operations experience
  • AND Previous managerial experience directly managing people and/or experience leading teams, projects, programs or directing the allocation of resources
Preferred Qualifications
  • Bachelor's degree in Life Sciences or Engineering
  • Experience with facility startup, commissioning, or operational readiness
  • Biologics / drug substance manufacturing experience (Upstream)
  • cGMP manufacturing experience (5+ years preferred)
  • Experience with technology transfer and process implementation
  • Prior Area Lead / Specialist / Manager experience
  • Strong leadership, performance management, and conflict resolution skills
  • Solid understanding of regulatory requirements
  • Proficiency with MES/EBR, DeltaV, Maximo, Veeva, LIMS, and electronic quality systems
What you can expect of us

As we develop treatments that take care of others, we also care for our teammates' professional and personal growth and well-being.

The annual base salary range for this opportunity in the U.S. is provided below.

In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
  • A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan.
  • Stock‑based long‑term incentives.
  • Award‑winning time‑off plans and bi‑annual company‑wide shutdowns.
  • Flexible work models, including remote work arrangements, where possible.
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