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Operational Readiness Manager Jobs in Raleigh, NC

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Operational Readiness Manager information

What is an operational readiness manager?

An Operational Readiness Manager is responsible for ensuring that a company’s people, processes, and systems are fully prepared for the launch or transition of new projects, systems, or facilities. They coordinate between various departments to identify potential risks, develop readiness plans, and implement solutions to ensure smooth operations from day one. Their role often involves change management, training, and testing to confirm that all operational requirements are met prior to go-live. This position is crucial in industries such as construction, IT, energy, and manufacturing, where seamless transitions are critical for business continuity.

How does an operational readiness manager collaborate with cross-functional teams during project rollouts?

Operational Readiness Managers work closely with departments such as engineering, IT, HR, and operations to ensure all aspects of a project are ready for launch. They facilitate regular meetings, coordinate readiness assessments, and align stakeholders on deliverables and timelines. This role often serves as a bridge between technical teams and business units, ensuring seamless communication and that potential risks or gaps are addressed early. Effective collaboration helps ensure a smooth transition from project phase to operational use, minimizing disruptions.

What are the key skills and qualifications needed to thrive as an operational readiness manager, and why are they important?

To excel as an Operational Readiness Manager, you need expertise in project management, risk assessment, process improvement, and a relevant bachelor's degree, often in business, engineering, or a related field. Familiarity with project management tools (like MS Project or Primavera), readiness assessment frameworks, and sometimes certifications such as PMP are typically required. Strong leadership, problem-solving, and communication skills help you coordinate cross-functional teams and manage complex transitions. These skills ensure seamless project launches, minimize operational disruptions, and drive continual organizational improvement.

What is the difference between Operational Readiness Manager vs Project Manager?

AspectOperational Readiness ManagerProject Manager
Primary FocusEnsuring operational systems and processes are prepared for launch or changePlanning, executing, and closing projects within scope, time, and budget
CertificationsCertifications like PMP, Six Sigma often preferredProject Management Professional (PMP), PRINCE2
Work EnvironmentOperations teams, cross-departmental coordinationProject teams, stakeholders, clients
Industry UsageCommon in industries with complex operational setups like manufacturing, energyWidely used across various industries for project execution

While both roles require strong project management skills and certifications, the Operational Readiness Manager focuses on preparing operational systems for deployment, whereas the Project Manager oversees the entire project lifecycle. Understanding these differences helps organizations assign the right responsibilities and find suitable candidates.

What are popular job titles related to Operational Readiness Manager jobs in Raleigh, NC?

For Operational Readiness Manager jobs in Raleigh, NC, the most frequently searched job titles are:

What job categories do people searching Operational Readiness Manager jobs in Raleigh, NC look for?

The top searched job categories for Operational Readiness Manager jobs in Raleigh, NC are:

What cities near Raleigh, NC are hiring for Operational Readiness Manager jobs?

Cities near Raleigh, NC with the most Operational Readiness Manager job openings:

Operational Readiness Manager jobs near you
Infographic showing various Operational Readiness Manager job openings in Raleigh, NC as of August 2026, with employment types broken down into 88% Full Time, and 12% Contract. Highlights an 70% In-person, 15% Hybrid, and 15% Remote job distribution.

Front Line Manufacturing Manager - Downstream Bulk Drug Substance - Days

Holly Springs, NC

Amgen
See more jobs at Amgenexternal

Full-time

Medical, Dental, Vision, Life, Retirement

Re-posted 17 days ago

Job description

Career CategoryManufacturingJob Description

HOW MIGHTYOUDEFY IMAGINATION?

You'veworked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills,experience,and passion to work toward your goals? At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over10 million patientsworldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the AmgenFleXBatch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. TheFleXBatch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.

Front Line Manufacturing Manager - Downstream Bulk Drug Substance - Days

What youwill do

Let'sdo this.Let'schange the world.Amgen is seeking aManager ManufacturingDownstreamto provide frontline leadership supporting the facility expansion program and facility startup. Thisessentialrole will lead a team responsible for manufacturingdownstream purification operations including column packing,columnchromatography, TFF,viralfiltration,viralinactivation, conjugation, and final fillwhile partnering across functions to ensure successful operational readiness, technology transfer, and rampup of manufacturing operations within the new facility.

The Manager will play a critical role supporting the design,build, startup, and operational phases of the facility expansion. The position will initially focus on facility startup and operational readiness activities, transitioning to manufacturing leadership as the facility becomes operational.During this phase of thestartup, you will be expected toworkaMonday - Friday schedule from 8am - 5pm.

This role may require work outside standard business hours, including nonstandard shifts, as needed to support startup, commissioning and qualification (C&Q), and engineering execution.As the business moves from C&Q to manufacturing operations, this essential positionwillwork ona 12-hour 2-2-3 schedule from 5:45 am to6:15pmsupporting our critical 24/7 manufacturing operations.As Amgen relies upon the regular attendance of all staff members to meet legitimate business needs, the Manager must be able to work assigned 12-hourshift, including during inclement weather, some holidays and requested overtime in support of our operations.

Responsibilities

  • Frontline Leadership:Lead, develop, and coach a manufacturing team; set clear performance expectations; foster a strong culture of safety, quality, and accountability.

  • Facility Startup & Operational Readiness:Support design, build, commissioning, qualification (C&Q), staffing, training, and readiness milestones for a new manufacturing facility.

  • Manufacturing Operations: Ensure safe, cGMPcompliant execution; drive performance across safety, quality, schedule, and cost; resolve deviations and operational issues.

  • Technology Transfer & Process Implementation:Support transfer and implementation of manufacturing processes; ensure manufacturability, troubleshooting, and continuous improvement.

  • CrossFunctional Collaboration:Partner with Quality, Engineering, NPI, Supply Chain, Validation, and Site Leadership to enable successful startup and rampup.

  • Compliance & Inspection Readiness:Maintaininspection readiness and adherence to regulatory and Amgen quality standards.

  • Continuous Improvement:Identifyand drive efficiency, reliability, and scalability improvements as operations mature.

  • Shift Support:Work nonstandard hours asrequired, transitioning to a 12hour 223 dayshift supporting 24/7 operations.

Win

What we expect from you

We are all different, yet we all use our unique contributions to serve patients. Thebiotechnologyprofessional weseekis amanagerwith these qualifications.

Basic Qualifications

  • Doctoratedegree OR

  • Master's degreeand3years ofManufacturing or Operationsexperience OR

  • Bachelor's degree and5years ofManufacturing or Operationsexperience OR

  • Associate's degree and 10 years of ManufacturingorOperations experience OR

  • High school diploma / GED and 12 years of ManufacturingorOperations experience

  • AND Previous managerial experience directly managing people and/or experience leading teams, projects, programs or directing the allocation of resources

Preferred Qualifications

  • Bachelor's degree in Life Sciences or Engineering

  • Experience with facility startup, commissioning, or operational readiness

  • Biologics / drug substance manufacturing experience (downstream)

  • cGMP manufacturing experience (5+ years preferred)

  • Experience with technology transfer and process implementation

  • Prior Area Lead / Specialist / Manager experience

  • Strong leadership, performance management, and conflictresolution skills

  • Solid understanding of regulatory requirements

  • Proficiencywith MES/EBR,DeltaV, Maximo, Veeva, LIMS, and electronic quality systems

Thrive

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being.

The annual base salary range for this opportunity in the U.S. is provided below.

In addition to the base salary, Amgen offers a Total Rewards Plancomprisinghealth and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

  • Stock-based long-term incentives

  • Award-winning time-off plans and bi-annual company-wide shutdowns

  • Flexible work models, including remote work arrangements, where possible

Apply nowfor a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen.com

#AmgenNorthCarolina

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Salary Range

106,148.00USD -143,612.00USD

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