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Ngs Library Preparation Jobs (NOW HIRING)

Natera

Associate Scientist, R&D

Austin, TX

Strong underlying scientific knowledge of nucleic acid extraction, PCR, NGS library preparation, and hybrid capture technologies * Hands-on experience in reagent preparation and quality control for ...

Baylor Genetics

Supervisor NGS Sequencing

Houston, TX · On-site

Including but not limited to molecular diagnostic techniques such as DNA extraction, PCR set up, liquid handler operations, or NGS library preparation and sequencing. * Demonstrates strong problem ...

Tempus

Molecular Technologist I-III

Triangle, VA · On-site

Perform next-generation sequencing, including nucleic acid extraction, DNA/RNA quantification and qualification, NGS library preparation, probe hybridization, probe/library capture, library cleanup ...

Tempus

Molecular Technologist I-III

Triangle, VA

Perform next-generation sequencing, including nucleic acid extraction, DNA/RNA quantification and qualification, NGS library preparation, probe hybridization, probe/library capture, library cleanup ...

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Ngs Library Preparation information

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How much do ngs library preparation jobs pay per hour?

As of Jul 7, 2026, the average hourly pay for ngs library preparation in the United States is $20.51, according to ZipRecruiter salary data. Most workers in this role earn between $15.87 and $24.04 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an NGS Library Preparation Specialist, and why are they important?

To excel in NGS Library Preparation, you need a solid background in molecular biology, experience with DNA/RNA extraction, and typically a bachelor's or higher degree in a life science field. Familiarity with sequencing platforms (such as Illumina or Ion Torrent), lab automation systems, and quality control instruments is essential. Attention to detail, strong organizational skills, and effective teamwork are vital soft skills for this role. These competencies ensure the accurate and efficient preparation of high-quality libraries, which is critical for reliable sequencing results and downstream analyses.

What are some common challenges faced during NGS library preparation, and how can they be addressed?

One common challenge in NGS library preparation is maintaining sample quality and integrity, as degraded or contaminated samples can compromise sequencing results. Another frequent issue is achieving consistent and efficient adapter ligation, which is crucial for successful downstream analysis. To address these, it's important to follow standardized protocols meticulously, use high-quality reagents, and incorporate quality control steps such as quantification and fragment analysis. Collaborating closely with bioinformaticians and other lab team members can also help troubleshoot issues early and optimize workflows for best results.

What is the difference between Ngs Library Preparation vs Ngs Sequencing Technician?

AspectNgs Library PreparationNgs Sequencing Technician
Primary RolePreparing DNA/RNA samples for sequencing, including library construction and quality controlOperating sequencing instruments, running sequencing runs, and troubleshooting
Required SkillsSample prep, pipetting, library QC, knowledge of sequencing protocolsInstrument operation, data collection, basic troubleshooting
Work EnvironmentLaboratory setting focused on sample prepLaboratory or sequencing facility operating sequencing machines
CertificationsOften requires molecular biology or lab technician certificationsTypically requires technical training in sequencing platforms

While Ngs Library Preparation involves preparing samples for sequencing, Ngs Sequencing Technicians focus on running and maintaining sequencing instruments. Both roles are essential in genomics workflows but differ in responsibilities and skill sets.

What is NGS library preparation?

NGS library preparation is a crucial step in the next-generation sequencing (NGS) workflow. It involves preparing DNA or RNA samples so they are compatible with sequencing platforms, usually by fragmenting the nucleic acids, adding adapters, and amplifying the resulting fragments. This process enables the sequencing machine to accurately read and analyze genetic information. Proper library preparation is essential for achieving high-quality sequencing data and reliable results.
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Ngs Library Preparation jobs near you
Infographic showing various Ngs Library Preparation job openings in the United States as of July 2026, with employment types broken down into 1% Internship, 1% As Needed, 80% Full Time, 15% Part Time, 1% Temporary, and 2% Contract. Highlights an 91% Physical, 2% Hybrid, and 7% Remote job distribution, with an average salary of $42,667 per year, or $20.5 per hour.
Staff Scientist, Research (DNA methylation)

Staff Scientist, Research (DNA methylation)

Natera

San Carlos, CA

Other

Posted 6 days ago

Natera rating

7.7

Company rating: 7.7 out of 10

Based on 35 frontline employees who took The Breakroom Quiz

50th of 103 rated laboratories

Job description

Natera is seeking a Staff Scientist to join our Epigenomics Research Team. The primary focus of this role is to independently lead the research and development of novel, methylation-based next-generation sequencing (NGS) technologies. In this role, you will lead projects from ideation to prototype, specifically designing and optimizing high-complexity NGS methods to advance our oncology diagnostic portfolio. Success in this role requires a deep technical foundation in DNA methylation and epigenomics plus a proven track record of industrial R&D leadership.

Primary Responsibilities:

  • Lead and manage the development of innovative NGS-based diagnostic assays from feasibility through optimization.

  • Define project goals and plans with input from stakeholders and manage multiple project streams in parallel.

  • Independently design and execute complex laboratory experiments; analyze and interpret results to guide research direction.

  • Coordinate cross-functional efforts to meet milestones and collaborate closely with bioinformatics, statistics, and data science teams to ensure robust experimental design and data analysis.

  • Mentor and guide junior scientists while promoting scientific rigor and best practices.

  • Author high-quality protocols, technical reports, and study documentation.

  • Communicate progress regularly to stakeholders, including departmental meetings and senior leadership.

  • Contribute to risk management, strategy development, and continuous improvement of scientific workflows.

Qualifications:

  • Ph.D. in molecular biology, genomics, or a closely related field.

  • Minimum 8 years of relevant industry experience, or 2+ years postdoctoral research with 6+ years in industry.

  • Proven experience in designing and advancing NGS-based diagnostics, preferably in the field of oncology.

Required Expertise:

  • Deep technical foundation in molecular biology or chemistry.

  • Extensive hands-on experience with NGS-based methylation detection and epigenomic workflows.

  • Demonstrated ability to independently design and execute complex experiments (solid DOE skills).

  • Creativity and ingenuity in solving high-ambiguity technical challenges.

  • Experience leading research projects in an industrial setting.

Preferred Skills:

  • Experience with cfDNA or liquid biopsy assay development.

  • Deep mechanistic knowledge of NGS library preparation chemistry.

  • Familiarity with translating early-stage research assays toward regulated product environments.

  • Proficiency in statistical analysis tools such as Excel, JMP, R, or Python; familiarity with bioinformatics workflows is a plus.

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