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Ngs Library Preparation Jobs (NOW HIRING)

Predicta Biosciences

R&D Scientist

Cambridge, MA · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

Contribute to development and optimization of NGS workflows, including library preparation, sample processing, and quality control * Develop and optimize sample processing workflows (whole blood ...

Predicta Biosciences

R&D Scientist

Cambridge, MA · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

Contribute to development and optimization of NGS workflows, including library preparation, sample processing, and quality control * Develop and optimize sample processing workflows (whole blood ...

PREDICTA BIOSCIENCES INC

R&D Scientist

Cambridge, MA · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

Contribute to development and optimization of NGS workflows, including library preparation, sample processing, and quality control * Develop and optimize sample processing workflows (whole blood ...

Tempus

NGS Senior Scientist 1

Chicago, IL · On-site

$95K - $120K/yr

NGS library preparation, hybrid capture, and sequencing workflows. * PCR-based techniques, including PCR, qPCR, RT-PCR, and ddPCR. * Nucleic acid manipulation, quantitation, and analysis. * Assay ...

Tempus

NGS Senior Scientist 1

Chicago, IL · On-site

$95K - $120K/yr

NGS library preparation, hybrid capture, and sequencing workflows. * PCR-based techniques, including PCR, qPCR, RT-PCR, and ddPCR. * Nucleic acid manipulation, quantitation, and analysis. * Assay ...

Freenome

Senior Research Associate

Brisbane, CA

$97K - $126K/yr

Design and perform experiments to develop, optimize, and characterize NGS workflow including DNA/RNA extraction, library preparation, target capture, and sequencing. * Operate and maintain NGS ...

Psomagen

Laboratory Technician / Scientist / Manager

Rockville, MD · On-site

$47K - $60K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Gel electrophoresis, PCR/qPCR, and NGS library preparation * Sequencing on Illumina, Ultima, PacBio, or 10x Genomics platforms * Single-cell assay setup and proteomics sample preparation * Operate ...

Freenome

Senior Research Associate

Brisbane, CA · On-site

$97K - $126K/yr

Design and perform experiments to develop, optimize, and characterize NGS workflow including DNA/RNA extraction, library preparation, target capture, and sequencing. * Operate and maintain NGS ...

AllSTEM Connections

Biologist

Boston, MA · On-site

$101K - $119K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

... NGS library preparation/QC, and qPCR. • Strong background in NGS technologies and their applications, including quantification, sequencing, and data QC (preferably Illumina). Direct experience with ...

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Ngs Library Preparation information

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How much do ngs library preparation jobs pay per hour?

As of Aug 17, 2026, the average hourly pay for ngs library preparation in the United States is $20.51, according to ZipRecruiter salary data. Most workers in this role earn between $15.87 and $24.04 per hour, depending on experience, location, and employer.

What is NGS library preparation?

NGS library preparation is a crucial step in the next-generation sequencing (NGS) workflow. It involves preparing DNA or RNA samples so they are compatible with sequencing platforms, usually by fragmenting the nucleic acids, adding adapters, and amplifying the resulting fragments. This process enables the sequencing machine to accurately read and analyze genetic information. Proper library preparation is essential for achieving high-quality sequencing data and reliable results.

What are some common challenges faced during NGS library preparation, and how can they be addressed?

One common challenge in NGS library preparation is maintaining sample quality and integrity, as degraded or contaminated samples can compromise sequencing results. Another frequent issue is achieving consistent and efficient adapter ligation, which is crucial for successful downstream analysis. To address these, it's important to follow standardized protocols meticulously, use high-quality reagents, and incorporate quality control steps such as quantification and fragment analysis. Collaborating closely with bioinformaticians and other lab team members can also help troubleshoot issues early and optimize workflows for best results.

What are the key skills and qualifications needed to thrive as an NGS library preparation specialist, and why are they important?

To excel in NGS Library Preparation, you need a solid background in molecular biology, experience with DNA/RNA extraction, and typically a bachelor's or higher degree in a life science field. Familiarity with sequencing platforms (such as Illumina or Ion Torrent), lab automation systems, and quality control instruments is essential. Attention to detail, strong organizational skills, and effective teamwork are vital soft skills for this role. These competencies ensure the accurate and efficient preparation of high-quality libraries, which is critical for reliable sequencing results and downstream analyses.

What is the difference between Ngs Library Preparation vs Ngs Sequencing Technician?

AspectNgs Library PreparationNgs Sequencing Technician
Primary RolePreparing DNA/RNA samples for sequencing, including library construction and quality controlOperating sequencing instruments, running sequencing runs, and troubleshooting
Required SkillsSample prep, pipetting, library QC, knowledge of sequencing protocolsInstrument operation, data collection, basic troubleshooting
Work EnvironmentLaboratory setting focused on sample prepLaboratory or sequencing facility operating sequencing machines
CertificationsOften requires molecular biology or lab technician certificationsTypically requires technical training in sequencing platforms

While Ngs Library Preparation involves preparing samples for sequencing, Ngs Sequencing Technicians focus on running and maintaining sequencing instruments. Both roles are essential in genomics workflows but differ in responsibilities and skill sets.

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Ngs Library Preparation jobs near you
Infographic showing various Ngs Library Preparation job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 76% Full Time, 21% Part Time, 1% Temporary, and 1% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $42,667 per year, or $20.5 per hour.

R&D Scientist

Predicta Biosciences

Cambridge, MA • On-site

Full-time

Medical, Dental, Vision, Retirement

Posted 28 days ago

Job description

Predicta is building a molecular insights platform for blood cancer care. From a single blood sample, we generate longitudinal genomic and immune insights that help clinicians and researchers better understand disease biology, guide treatment decisions, and monitor disease evolution over time.
We are seeking a highly motivated R&D Scientist who will lead assay development efforts spanning flow cytometry and NGS technologies, including whole genome sequencing and single-cell RNA-seq. The ideal candidate has a strong technical background in immunology, cell biology, and genomics, with experience developing highly robust and reproducible assays deployed in clinical or research settings. This individual will play a key role in developing assays for the characterization of tumor and immune cells, from multi-color flow cytometry immunophenotyping and FACS-based sorting through to downstream NGS library preparation and sequencing, translating early research concepts into clinical assays.
This laboratory-based scientist should be passionate about developing cutting-edge cytometry and genomic assays and will work closely with an inter-disciplinary and cross-functional team of other laboratory-based scientists and computational biologists, focused on improving blood-based cancer diagnostic capabilities in areas including cancer detection, measurable residual disease, and other related applications.
Key responsibilities
  • Design, develop, and optimize molecular assays spanning flow cytometry and NGS for tumor cell and immune characterization
  • Lead multi-color and spectral flow cytometry panel design (10-30+ colors), fluorophore selection, antibody titration, and FACS-based cell sorting
  • Contribute to development and optimization of NGS workflows, including library preparation, sample processing, and quality control
  • Develop and optimize sample processing workflows (whole blood, bone marrow, PBMC isolation) that feed both flow cytometry and NGS/single-cell pipelines
  • Use FACS to identify rare cell populations for downstream single-cell RNA-seq and other NGS applications
  • Evaluate and implement new technologies, reagents, and platforms spanning cytometry (e.g., spectral flow) and sequencing to improve assay performance, robustness, and scalability
  • Establish and maintain QC metrics, instrument standardization, and assay validation practices across both cytometry and sequencing workflows
  • Plan and execute experiments independently, analyze data (FlowJo for flow; and standard NGS QC pipelines), and clearly communicate results to internal stakeholders
  • Collaborate closely with the R&D and computational biology teams to ensure seamless integration of wet-lab and analytical workflows across modalities
  • Develop and document standard operating procedures (SOPs), protocols, and technical reports suitable for regulated environments
  • Maintain meticulous, reproducible records and contribute to shared protocols
  • Follow, document, and adapt experimental protocols with care and precision
  • Mentor junior scientists and contribute to building best practices within the R&D organization
  • Support technology transfer from R&D into product development and clinical operations as needed

Requirements
  • PhD (or BS/MSc with significant industry experience) in immunology, molecular biology, cell biology, genetics, bioengineering, or a related field
  • 5+ years of hands-on laboratory experience spanning flow cytometry/immunophenotyping and molecular biology assay development, preferably in a cutting-edge research/R&D environment
  • Deep expertise in multi-parameter and spectral flow cytometry, including panel design, instrument operation and FACS-based cell sorting
  • Deep expertise in NGS technologies, including library prep, sequencing platforms, and workflow optimization; experience with single-cell RNA-seq or related single-cell technologies (scWGS, scATAC-seq, scMultiomics) is a strong plus
  • Strong understanding of immune cell subsets and immunophenotyping, particularly in the context of hematologic malignancies
  • Hands-on experience with compensation, fluorescence-minus-one (FMO) controls, and gating strategy development
  • Strong experimental design, troubleshooting, and data interpretation skills
  • Demonstrated success working in cross-functional, fast-moving research or startup environments and collaborating with computational scientists
  • Outstanding written and verbal communication skills
  • Ability to handle several fast-paced projects concurrently
  • Demonstrated curiosity and scientific rigor with excellent problem-solving skills
  • Ability to engage in crucial conversations - providing and receiving feedback

Preferred qualifications
  • Hands-on experience linking flow cytometry-sorted populations directly into NGS or single-cell library preparation workflows
  • Experience developing assays intended for clinical or regulated use (e.g., CLIA, CAP, or FDA-regulated environments)
  • Familiarity with computational methods and software for analysis of flow cytometry and/or NGS data, especially for quality control
  • Prior experience bringing assays from early research through to product development
  • Experience with automation of cell and molecular biology assays, especially sample extraction, cell staining/sorting, and NGS library preparation
  • Background in immunology, immuno-oncology, or immune-mediated diseases

Work Location
  • This role is based in Cambridge, MA and is a full time in-office role. Travel may be required in the future.

Why Join Predicta Biosciences?
This is a unique opportunity to be part of a mission-driven team advancing precision diagnostics for hematologic cancers. You'll play a key role in shaping the quality and performance of our clinical testing efforts and contribute directly to patient-impactful innovations.
The annual salary range for this position is $120,000 - $180,000 plus a 10% bonus opportunity. Predicta considers a variety of factors when determining base compensation, including experience, skills, education, qualifications, and geographic location. Actual compensation will vary, and it is not typical to be hired at or near the top of the range for the role. Additional rewards include equity, flexible time off, 401k Plan, medical, dental and vision plans that are 90% paid by Predicta and a partially company-funded HSA.

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