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Ngs Library Preparation Jobs in Virginia (NOW HIRING)

Tempus

Molecular Technologist I-III

Triangle, VA · On-site

Perform next-generation sequencing, including nucleic acid extraction, DNA/RNA quantification and qualification, NGS library preparation, probe hybridization, probe/library capture, library cleanup ...

Tempus

Molecular Technologist I-III

Triangle, VA · On-site

Perform next-generation sequencing, including nucleic acid extraction, DNA/RNA quantification and qualification, NGS library preparation, probe hybridization, probe/library capture, library cleanup ...

All JobsNgs Library Preparation JobsNgs Library Preparation Jobs in Virginia

Ngs Library Preparation information

What is NGS library preparation?

NGS library preparation is a crucial step in the next-generation sequencing (NGS) workflow. It involves preparing DNA or RNA samples so they are compatible with sequencing platforms, usually by fragmenting the nucleic acids, adding adapters, and amplifying the resulting fragments. This process enables the sequencing machine to accurately read and analyze genetic information. Proper library preparation is essential for achieving high-quality sequencing data and reliable results.

What are some common challenges faced during NGS library preparation, and how can they be addressed?

One common challenge in NGS library preparation is maintaining sample quality and integrity, as degraded or contaminated samples can compromise sequencing results. Another frequent issue is achieving consistent and efficient adapter ligation, which is crucial for successful downstream analysis. To address these, it's important to follow standardized protocols meticulously, use high-quality reagents, and incorporate quality control steps such as quantification and fragment analysis. Collaborating closely with bioinformaticians and other lab team members can also help troubleshoot issues early and optimize workflows for best results.

What are the key skills and qualifications needed to thrive as an NGS library preparation specialist, and why are they important?

To excel in NGS Library Preparation, you need a solid background in molecular biology, experience with DNA/RNA extraction, and typically a bachelor's or higher degree in a life science field. Familiarity with sequencing platforms (such as Illumina or Ion Torrent), lab automation systems, and quality control instruments is essential. Attention to detail, strong organizational skills, and effective teamwork are vital soft skills for this role. These competencies ensure the accurate and efficient preparation of high-quality libraries, which is critical for reliable sequencing results and downstream analyses.

What is the difference between Ngs Library Preparation vs Ngs Sequencing Technician?

AspectNgs Library PreparationNgs Sequencing Technician
Primary RolePreparing DNA/RNA samples for sequencing, including library construction and quality controlOperating sequencing instruments, running sequencing runs, and troubleshooting
Required SkillsSample prep, pipetting, library QC, knowledge of sequencing protocolsInstrument operation, data collection, basic troubleshooting
Work EnvironmentLaboratory setting focused on sample prepLaboratory or sequencing facility operating sequencing machines
CertificationsOften requires molecular biology or lab technician certificationsTypically requires technical training in sequencing platforms

While Ngs Library Preparation involves preparing samples for sequencing, Ngs Sequencing Technicians focus on running and maintaining sequencing instruments. Both roles are essential in genomics workflows but differ in responsibilities and skill sets.

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Ngs Library Preparation jobs near you

Molecular Technologist I-III

Tempus

Triangle, VA • On-site

Full-time

Re-posted 24 days ago

Job description

Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

Responsibilities:
Work with a cutting-edge genomics workflow to provide high-quality next-generation sequencing data with rapid turnaround times in a clinical laboratory.
Perform routine testing, quality control, calibration, maintenance and proficiency testing in accordance with current laboratory procedures.
Perform complex molecular-based procedures with a high degree of quality and in accordance with established protocols.

Perform next-generation sequencing, including nucleic acid extraction, DNA/RNA quantification and qualification, NGS library preparation, probe hybridization, probe/library capture, library cleanup and quantification, loading sequencing libraries onto the Illumina Nextseq, HiSeq4000, and Novaseq.
Sterilizing laboratory equipment and workspaces as assigned.
Entering clinical patient data into the Laboratory Information Management system.

Obtain 12 continuing education hours in the field of oncology or molecular biology.
Maintain competency to perform all assigned molecular biology protocols in accordance with CAP, CLIA, NYSDOH regulations.
Qualifications:
Must have:

One of the following educational requirements:

  • MS in medical technology, clinical laboratory science, chemical, physical or biological science and 1 year pertinent clinical laboratory experience with molecular biology
  • BS/BA in medical technology, clinical laboratory science, chemical, physical or biological science and 1 year of pertinent clinical lab experience in molecular biology

- Excellent communication skills
- Thrives in a fast-paced environment
- Ability to work with others to plan and carry out scientific programs
- Self-driven and works well in an interdisciplinary team with minimal direction
- Strong desire to build products that will save lives and change the course of cancer
- Impeccable attention to detail

Highly Desirable:
- Experience with next-generation sequencing
- Work in a CLIA/CAP high-complexity laboratory
- Experience with robotics and automated liquid handling systems
- Knowledge of LIMS platforms and various computer systems

We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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