Prepare NGS libraries for all the labs in MCTP as well as other collaborators, helping the research sequencing group manage the increasing volume of libraries (RNA-Seq, ChIP-Seq, Capture-Seq and etc.
Prepare NGS libraries for all the labs in MCTP as well as other collaborators, helping the research sequencing group manage the increasing volume of libraries (RNA-Seq, ChIP-Seq, Capture-Seq and etc.
Ngs Library Preparation information
What is NGS library preparation?
NGS library preparation is a crucial step in the next-generation sequencing (NGS) workflow. It involves preparing DNA or RNA samples so they are compatible with sequencing platforms, usually by fragmenting the nucleic acids, adding adapters, and amplifying the resulting fragments. This process enables the sequencing machine to accurately read and analyze genetic information. Proper library preparation is essential for achieving high-quality sequencing data and reliable results.
What are some common challenges faced during NGS library preparation, and how can they be addressed?
One common challenge in NGS library preparation is maintaining sample quality and integrity, as degraded or contaminated samples can compromise sequencing results. Another frequent issue is achieving consistent and efficient adapter ligation, which is crucial for successful downstream analysis. To address these, it's important to follow standardized protocols meticulously, use high-quality reagents, and incorporate quality control steps such as quantification and fragment analysis. Collaborating closely with bioinformaticians and other lab team members can also help troubleshoot issues early and optimize workflows for best results.
What are the key skills and qualifications needed to thrive as an NGS library preparation specialist, and why are they important?
To excel in NGS Library Preparation, you need a solid background in molecular biology, experience with DNA/RNA extraction, and typically a bachelor's or higher degree in a life science field. Familiarity with sequencing platforms (such as Illumina or Ion Torrent), lab automation systems, and quality control instruments is essential. Attention to detail, strong organizational skills, and effective teamwork are vital soft skills for this role. These competencies ensure the accurate and efficient preparation of high-quality libraries, which is critical for reliable sequencing results and downstream analyses.
What is the difference between Ngs Library Preparation vs Ngs Sequencing Technician?
| Aspect | Ngs Library Preparation | Ngs Sequencing Technician |
|---|---|---|
| Primary Role | Preparing DNA/RNA samples for sequencing, including library construction and quality control | Operating sequencing instruments, running sequencing runs, and troubleshooting |
| Required Skills | Sample prep, pipetting, library QC, knowledge of sequencing protocols | Instrument operation, data collection, basic troubleshooting |
| Work Environment | Laboratory setting focused on sample prep | Laboratory or sequencing facility operating sequencing machines |
| Certifications | Often requires molecular biology or lab technician certifications | Typically requires technical training in sequencing platforms |
While Ngs Library Preparation involves preparing samples for sequencing, Ngs Sequencing Technicians focus on running and maintaining sequencing instruments. Both roles are essential in genomics workflows but differ in responsibilities and skill sets.
What are popular job titles related to Ngs Library Preparation jobs in Michigan?
For Ngs Library Preparation jobs in Michigan, the most frequently searched job titles are:
What job categories do people searching Ngs Library Preparation jobs in Michigan look for?
The top searched job categories for Ngs Library Preparation jobs in Michigan are:
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What cities in Michigan are hiring for Ngs Library Preparation jobs?
Cities in Michigan with the most Ngs Library Preparation job openings:
Full-time
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Re-posted 2 days ago
University Of Michigan rating
8.1
Based on 145 frontline employees who took The Breakroom Quiz
164th of 620 rated colleges and universities
Job description
How to Apply
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
Mission Statement
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Job Summary
Join the expanding Michigan Center for Translational Pathology laboratory to work in the research sequencing team. Our laboratory uses high-throughput technologies to understand the mechanisms of cancer progression and to develop new prognostic/diagnostic biomarkers of cancer. The laboratory provides enormous resources and opportunities for an individual to learn traditional cellular/molecular techniques as well as state-of-the-art technologies, including Next Generation Sequencing, single cell sequencing, and spatial transcriptomics.
Responsibilities*
Required Qualifications*
Desired Qualifications*
Why Join Michigan Medicine?
Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.
What Benefits can you Look Forward to?
Modes of Work
Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes .
Background Screening
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Application Deadline
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled any time after the minimum posting period has ended.
U-M EEO Statement
The University of Michigan is an Equal Opportunity Employer. We are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants, including protected veterans and individuals with disabilities.
Job Detail
Job Opening ID
281223
Working Title
Research Lab Specialist Inter
Job Title
Research Lab Specialist Inter
Work Location
Ann Arbor Campus
Ann Arbor, MI
Modes of Work
Onsite
Full/Part Time
Full-Time
Regular/Temporary
Regular
FLSA Status
Exempt
Organizational Group
Medical School
Department
MM Ctr fr Translational Path.
Posting Begin/End Date
8/05/2026 - 8/19/2026
Career Interest
Research
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
Mission Statement
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Job Summary
Join the expanding Michigan Center for Translational Pathology laboratory to work in the research sequencing team. Our laboratory uses high-throughput technologies to understand the mechanisms of cancer progression and to develop new prognostic/diagnostic biomarkers of cancer. The laboratory provides enormous resources and opportunities for an individual to learn traditional cellular/molecular techniques as well as state-of-the-art technologies, including Next Generation Sequencing, single cell sequencing, and spatial transcriptomics.
Responsibilities*
- Isolate RNA and DNA from tissues and blood and prepare samples through PCR and gel electrophoresis for sequencing.
- Check sample quality via spectrophotometer, bioanalyzer, and qPCR.
- Prepare NGS libraries for all the labs in MCTP as well as other collaborators, helping the research sequencing group manage the increasing volume of libraries (RNA-Seq, ChIP-Seq, Capture-Seq and etc.).
- Support library prep for single-cell and spatial transcriptomics libraries, including work on Xenium, CytoAssist, and advanced sequencing platforms.
- Run next-generation sequencing platforms, including Xenium, and support related library preparation workflows.
- Validate potential candidate genes by Sanger sequencing and qPCR.
- Write internal research reports summarizing research activities.
- Participate in group meetings and interact as a team member with laboratory personnel.
- Maintain and update all documentation for lab annual inspections, including writing SOPs, performing scheduled maintenance, and running various assays.
- Run instrument validations and verifications for new and existing platforms. Testing and optimizing new technologies and new protocols.
- The candidate should be very familiar and experienced with basic molecular biology and cell biology techniques and should have strong organizational skills to complete work in a timely manner.
Required Qualifications*
- Master's degree in biology or a related field.
- Minimum of five years' experience in basic laboratory research.
- Experience in a molecular biology and/or biochemistry research laboratory.
- Familiarity with qPCR techniques, molecular cloning, and cell culture.
- Experience with NGS library preparation (RNA-Seq, ChIP-Seq, Capture-Seq, etc.).
- Strong foundation in basic molecular and cell biology techniques.
- Willingness to learn new concepts and technologies, including single-cell and spatial transcriptomics platforms. Experience in assay development and validation.
- Demonstrated ability to work collaboratively across multiple concurrent projects and with a range of collaborators.
- Excellent organizational skills, attention to detail, and record-keeping, with the ability to complete work in a timely manner.
Desired Qualifications*
- PhD in biological science or a related field.
- Prior hands-on experience with single-cell or spatial transcriptomics platforms.
Why Join Michigan Medicine?
Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.
What Benefits can you Look Forward to?
- Excellent medical, dental and vision coverage effective on your very first day
- 2:1 Match on retirement savings
Modes of Work
Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes .
Background Screening
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Application Deadline
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled any time after the minimum posting period has ended.
U-M EEO Statement
The University of Michigan is an Equal Opportunity Employer. We are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants, including protected veterans and individuals with disabilities.
Job Detail
Job Opening ID
281223
Working Title
Research Lab Specialist Inter
Job Title
Research Lab Specialist Inter
Work Location
Ann Arbor Campus
Ann Arbor, MI
Modes of Work
Onsite
Full/Part Time
Full-Time
Regular/Temporary
Regular
FLSA Status
Exempt
Organizational Group
Medical School
Department
MM Ctr fr Translational Path.
Posting Begin/End Date
8/05/2026 - 8/19/2026
Career Interest
Research
What University Of Michigan employees say
Pay
Benefits
Hours and flexibility
Workplace
Get the full story on Breakroom
About University of Michigan
Sourced by ZipRecruiter
The University of Michigan (U-M), based in Ann Arbor, MI, US, is one of America's most esteemed institutions in higher education. Established in 1817, it presides in the industry of education and research, providing a range of services including undergraduate, graduate, and professional education programs. Complementing this is an extensive research activity that has significantly contributed to various fields, from healthcare to engineering, humanities to sports. Upholding its mission "to serve the people of Michigan and the world through preeminence in creating, communicating, preserving and applying knowledge, art, and academic values", U-M consistently ranks among the top universities globally, a testament to its tradition of excellence in learning and research, and a deep commitment to innovation and discovery.
Industry
Colleges, universities, and professional schools
Company size
10,000+ Employees
Headquarters location
Ann Arbor, MI, US
Year founded
1817