The Downstream Process Development team is seeking a highly motivated scientist to drive innovation in viral vector purification. The successful candidate will lead platform development to advance ...
The Downstream Process Development team is seeking a highly motivated scientist to drive innovation in viral vector purification. The successful candidate will lead platform development to advance ...
Role OverviewThe Principal Engineer, Lentivirus Downstream Process Development, will be a key ... The successful candidate will drive scientific excellence in scaling automation capabilities from ...
Role OverviewThe Principal Engineer, Lentivirus Downstream Process Development, will be a key ... The successful candidate will drive scientific excellence in scaling automation capabilities from ...
Senior Scientist, Downstream Process Development / Optimization Elanco is seeking a Senior Scientist, Downstream Process Development to lead purification process development and optimization for ...
Senior Scientist, Downstream Process Development / Optimization Elanco is seeking a Senior Scientist, Downstream Process Development to lead purification process development and optimization for ...
The Downstream Process Development team is seeking a highly motivated scientist to drive innovation in viral vector purification. The successful candidate will lead platform development to advance ...
The Downstream Process Development team is seeking a highly motivated scientist to drive innovation in viral vector purification. The successful candidate will lead platform development to advance ...
Company Description Eurofins Scientific is an international life sciences company, providing a ... Perform lab-scale downstream processing of vaccine adjuvant & Lipid Nanoparticle (LNP) products and ...
Company Description Eurofins Scientific is an international life sciences company, providing a ... Perform lab-scale downstream processing of vaccine adjuvant & Lipid Nanoparticle (LNP) products and ...
Join Takeda as a Downstream Process Development, Engineer II. As an early-career professional, you handle problems of limited scope and complexity, adhering to established policies and procedures.
Join Takeda as a Downstream Process Development, Engineer II. As an early-career professional, you handle problems of limited scope and complexity, adhering to established policies and procedures.
Associate Director, Downstream Process Development Allakos Inc. is a clinical-stage company developing therapeutic antibodies for inhibitory receptors on the surface of immune effector cells involved ...
Associate Director, Downstream Process Development Allakos Inc. is a clinical-stage company developing therapeutic antibodies for inhibitory receptors on the surface of immune effector cells involved ...
Senior Scientist -Technical Services, Downstream Process Improvement
Indianapolis, IN · On-site
$87K - $119K/yr
Senior Scientist, Downstream Process Development / Optimization Elanco is seeking a Senior Scientist, Downstream Process Development to lead purification process development and optimization for ...
Senior Scientist -Technical Services, Downstream Process Improvement
Indianapolis, IN · On-site
$87K - $119K/yr
Senior Scientist, Downstream Process Development / Optimization Elanco is seeking a Senior Scientist, Downstream Process Development to lead purification process development and optimization for ...
Join Takeda as a Downstream Process Development, Engineer II. As an early-career professional, you handle problems of limited scope and complexity, adhering to established policies and procedures.
Join Takeda as a Downstream Process Development, Engineer II. As an early-career professional, you handle problems of limited scope and complexity, adhering to established policies and procedures.
Minimum of 10 years of experience with downstream purification process development in the biopharma ... Strong scientific reasoning, problem-solving, and applied statistics skills, including the ability ...
Minimum of 10 years of experience with downstream purification process development in the biopharma ... Strong scientific reasoning, problem-solving, and applied statistics skills, including the ability ...
Manager - Process Development, Downstream Position Summary: * Work Schedule: M-F 8am-5pm * 100% on ... People and technical leadership experience, including mentoring scientists and managing execution ...
Manager - Process Development, Downstream Position Summary: * Work Schedule: M-F 8am-5pm * 100% on ... People and technical leadership experience, including mentoring scientists and managing execution ...
Manager - Process Development, Downstream Position Summary: * Work Schedule: M-F 8am-5pm * 100% on ... People and technical leadership experience, including mentoring scientists and managing execution ...
Manager - Process Development, Downstream Position Summary: * Work Schedule: M-F 8am-5pm * 100% on ... People and technical leadership experience, including mentoring scientists and managing execution ...
The PD Scientist is responsible for the development of current and new manufacturing processes. Key responsibilities. * Develop, conduct, and/or manage the process development of current and new ...
The PD Scientist is responsible for the development of current and new manufacturing processes. Key responsibilities. * Develop, conduct, and/or manage the process development of current and new ...
Lead and mentor a team of downstream process development scientists and engineers * Set the technical direction and strategic priorities for the Downstream Processing function. * Define and track key ...
Lead and mentor a team of downstream process development scientists and engineers * Set the technical direction and strategic priorities for the Downstream Processing function. * Define and track key ...
Lead and mentor a team of downstream process development scientists and engineers * Set the technical direction and strategic priorities for the Downstream Processing function. * Define and track key ...
Lead and mentor a team of downstream process development scientists and engineers * Set the technical direction and strategic priorities for the Downstream Processing function. * Define and track key ...
The PD Scientist is responsible for the development of current and new manufacturing processes. Key responsibilities. * Develop, conduct, and/or manage the process development of current and new ...
The PD Scientist is responsible for the development of current and new manufacturing processes. Key responsibilities. * Develop, conduct, and/or manage the process development of current and new ...
Position description Process Development Scientist The Department of Laboratory Medicine at the University of California, San Francisco(UCSF) is seeking a motivated Process Development Scientist to ...
Position description Process Development Scientist The Department of Laboratory Medicine at the University of California, San Francisco(UCSF) is seeking a motivated Process Development Scientist to ...
Downstream Development Associate II
$38 - $45/hr
... Process Science & Validation Team. The Lu-SBP team leads and supports the development of new ... Summary: Performs downstream process development experiments and supporting activities, which ...
Downstream Development Associate II
$38 - $45/hr
... Process Science & Validation Team. The Lu-SBP team leads and supports the development of new ... Summary: Performs downstream process development experiments and supporting activities, which ...
Downstream Development Associate II
Bothell, WA · On-site
$38 - $45/hr
... Process Science & Validation Team. The Lu-SBP team leads and supports the development of new ... Summary: Performs downstream process development experiments and supporting activities, which ...
Downstream Development Associate II
Bothell, WA · On-site
$38 - $45/hr
... Process Science & Validation Team. The Lu-SBP team leads and supports the development of new ... Summary: Performs downstream process development experiments and supporting activities, which ...
Senior Scientist, Process Development
Gaithersburg, MD · On-site
$113K - $181K/yr
As a Senior Scientist I in Process Development at BioNTech, you will play a key role in advancing ... In this role, you will leverage your expertise in downstream processing to develop scalable ...
Senior Scientist, Process Development
Gaithersburg, MD · On-site
$113K - $181K/yr
As a Senior Scientist I in Process Development at BioNTech, you will play a key role in advancing ... In this role, you will leverage your expertise in downstream processing to develop scalable ...
Downstream Process Development Scientist information
See salary details
$20.67 - $24.39
6% of jobs
$24.39 - $28.10
17% of jobs
$28.40 is the 25th percentile. Wages below this are outliers.
$28.10 - $31.82
20% of jobs
The median wage is $34.05 / hr.
$31.82 - $35.53
11% of jobs
$35.53 - $39.25
13% of jobs
$39.25 - $42.96
3% of jobs
$44.48 is the 75th percentile. Wages above this are outliers.
$42.96 - $46.68
12% of jobs
$46.68 - $50.39
7% of jobs
$50.39 - $54.11
4% of jobs
$54.11 - $57.82
3% of jobs
$57.82 - $61.54
3% of jobs
$20
$38
$61
How much do downstream process development scientist jobs pay per hour?
As of Sep 2, 2026, the average hourly pay for downstream process development scientist in the United States is $38.66, according to ZipRecruiter salary data. Most workers in this role earn between $28.37 and $46.15 per hour, depending on experience, location, and employer.
What is a downstream process development scientist?
A Downstream Process Development Scientist is responsible for developing and optimizing processes to purify biological products, such as proteins, antibodies, or vaccines, after they are produced in upstream bioprocessing. They work with techniques like filtration, chromatography, and centrifugation to refine and scale up purification methods for manufacturing. Their role involves ensuring product quality, improving yields, and troubleshooting any processing challenges. Scientists in this field collaborate with cross-functional teams, including upstream development, analytical sciences, and manufacturing, to ensure efficient and scalable bioprocesses.
What are the key skills and qualifications needed to thrive as a downstream process development scientist?
To thrive as a Downstream Process Development Scientist, you need expertise in biochemistry, chemical engineering, and purification techniques, typically supported by a relevant science degree or higher. Experience with protein chromatography systems, filtration equipment, and data analysis software is highly valued, along with familiarity with GMP and regulatory requirements. Strong analytical thinking, problem-solving abilities, and effective teamwork and communication are key soft skills for this position. These competencies are crucial for optimizing manufacturing processes and ensuring the successful scale-up of biologic products in a collaborative environment.
What typical challenges might a downstream process development scientist encounter in their daily work?
Downstream Process Development Scientists often face challenges related to optimizing purification processes to achieve high yield and product purity, while maintaining efficiency and scalability. They may need to troubleshoot issues with chromatography, filtration, or product stability, sometimes under tight timelines. Working closely with cross-functional teams—including upstream development, quality control, and manufacturing—is common for resolving complex technical problems. Adaptability and continuous learning are important, as methods and equipment may evolve based on project needs and technological advancements.
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Who are the top companies hiring for Downstream Process Development Scientist jobs?
The top employers for Downstream Process Development Scientist jobs are:
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States with the most job openings for Downstream Process Development Scientist jobs include:
What job categories do people searching Downstream Process Development Scientist jobs look for?
The top searched job categories for Downstream Process Development Scientist jobs are:
- Associate Process Development Scientist
- Upstream Process Development Scientist
- Manager Downstream Process Development Scientist
- Senior Scientist Downstream Process Development
- Downstream Scientist
- Phd Drug Development Scientist
- Process Development Scientist Amgen
- Retired Scientist
- Vice President Scientist Process Chemistry
- Product Process Development Scientist
Full-time
Medical, Dental, Vision, Life, Retirement, PTO
Re-posted 22 days ago
Eli Lilly and Company rating
8.8
Based on 63 frontline employees who took The Breakroom Quiz
11th of 86 rated pharmaceutical
Job description
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work-but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.
The Downstream Process Development team is seeking a highly motivated scientist to drive innovation in viral vector purification. The successful candidate will lead platform development to advance DSP capabilities for recombinant adeno-associated virus (AAV) gene therapy products, supporting programs from early development through GMP manufacturing and regulatory submission; collaborating with Analytical Development, CMC Regulatory, and MFG to deliver robust, scalable and efficient manufacturing processes.
Key Responsibilities
Basic Qualifications
Preferred Qualifications
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$138,000 - $202,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
The Downstream Process Development team is seeking a highly motivated scientist to drive innovation in viral vector purification. The successful candidate will lead platform development to advance DSP capabilities for recombinant adeno-associated virus (AAV) gene therapy products, supporting programs from early development through GMP manufacturing and regulatory submission; collaborating with Analytical Development, CMC Regulatory, and MFG to deliver robust, scalable and efficient manufacturing processes.
Key Responsibilities
- Design and execute downstream process development experiments for AAV purification, including affinity capture, ion-exchange chromatography, ultrafiltration/diafiltration, viral filtration, and ultracentrifugation
- Develop and implement novel AAV purification strategies; establish DSP operating principles and process understanding across diverse serotypes.
- Develop and apply mechanistic chromatography models to predict column performance, guide operating condition selection, and accelerate scale-up decisions, enabling rapid initiation of new gene therapy programs.
- Collaborate cross-functionally with upstream process development, analytical development, manufacturing, and quality teams to ensure seamless technology transfer and successful clinical manufacturing.
- Present experimental findings at internal team meetings, cross-functional reviews, and external conferences; contribute to scientific publications and patent applications as appropriate.
- Author and review technical documents including process descriptions, batch records, process characterization reports, and CMC sections of IND/BLA filings.
- Mentor junior scientists, encouraging a culture of scientific excellence and continuous improvement.
Basic Qualifications
- Ph.D. in Chemical Engineering, Biochemical Engineering, Bioengineering, or a related scientific discipline with 2+ years of relevant experience in downstream process development for biologics or gene therapy products, OR M.S. in Chemical Engineering, Biochemical Engineering, Bioengineering, or a related scientific discipline with 10+ years of relevant industry experience
- Extensive hands-on experience with various protein purification techniques: chromatography (affinity, ion exchange, HIC) and membrane-based separations (UF/DF, depth filtration).
- Proficiency in statistical design of experiments (JMP, Minitab) and data analysis.
Preferred Qualifications
- Experience with recombinant AAV or other viral vector purification (lentivirus, adenovirus).
- Experience with automation platforms for HTP process screening
- Proficiency in Python and/or MATLAB for data analysis, model implementation, and automation scripting
- Knowledge of machine learning / multivariate analysis applied to bioprocess data
- Strong understanding of viral vector biology, expression systems, and analytical methods used for viral vector characterization.
- Excellent problem-solving skills, critical thinking, and ability to work independently and as part of a team.
- Strong written and verbal communication skills with the ability to effectively present complex scientific information.
- Adaptability in a fast-paced environment
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$138,000 - $202,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
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About Eli Lilly
Sourced by ZipRecruiter
Eli Lilly, based in Indianapolis, IN, US, is one of the pioneers in the pharmaceutical industry with a rich history dating back to 1876. This global pharmaceutical company focuses on discovering, developing, manufacturing and selling pharmaceutical products in approximately 120 countries. The company's product categories include endocrinology, oncology, cardiovascular, neuroscience, and immunology. Having invested over $9 billion in research and development in the past decade, Eli Lilly is also committed to creating high-quality medicines that meet real needs. As a recipient of several awards and recognitions, Eli Lilly is known for its focus on life-saving research and drug development. Their mission is to make medicines that help people live longer, healthier, and more active lives.
Industry
Pharmaceutical product wholesalers
Company size
10,000+ Employees
Headquarters location
Indianapolis, IN, US
Year founded
1876