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Downstream Process Development Scientist Jobs (NOW HIRING)

Legend Biotech USA, Inc.

The successful candidate will drive scientific excellence in downstream processing (DSP)-including ... Direct the development and optimization of downstream processes including and not limited to ...

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How much do downstream process development scientist jobs pay per hour?

As of Aug 12, 2026, the average hourly pay for downstream process development scientist in the United States is $38.66, according to ZipRecruiter salary data. Most workers in this role earn between $28.37 and $46.15 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a downstream process development scientist?

To thrive as a Downstream Process Development Scientist, you need expertise in biochemistry, chemical engineering, and purification techniques, typically supported by a relevant science degree or higher. Experience with protein chromatography systems, filtration equipment, and data analysis software is highly valued, along with familiarity with GMP and regulatory requirements. Strong analytical thinking, problem-solving abilities, and effective teamwork and communication are key soft skills for this position. These competencies are crucial for optimizing manufacturing processes and ensuring the successful scale-up of biologic products in a collaborative environment.

What typical challenges might a downstream process development scientist encounter in their daily work?

Downstream Process Development Scientists often face challenges related to optimizing purification processes to achieve high yield and product purity, while maintaining efficiency and scalability. They may need to troubleshoot issues with chromatography, filtration, or product stability, sometimes under tight timelines. Working closely with cross-functional teams—including upstream development, quality control, and manufacturing—is common for resolving complex technical problems. Adaptability and continuous learning are important, as methods and equipment may evolve based on project needs and technological advancements.

What is a downstream process development scientist?

A Downstream Process Development Scientist is responsible for developing and optimizing processes to purify biological products, such as proteins, antibodies, or vaccines, after they are produced in upstream bioprocessing. They work with techniques like filtration, chromatography, and centrifugation to refine and scale up purification methods for manufacturing. Their role involves ensuring product quality, improving yields, and troubleshooting any processing challenges. Scientists in this field collaborate with cross-functional teams, including upstream development, analytical sciences, and manufacturing, to ensure efficient and scalable bioprocesses.

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Downstream Process Development Scientist jobs near you
Infographic showing various Downstream Process Development Scientist job openings in the United States as of August 2026, with employment types broken down into 89% Full Time, and 11% Contract. Highlights an 94% In-person, and 6% Hybrid job distribution, with an average salary of $80,420 per year, or $38.7 per hour.

Process Development Scientist, Biocatalysis

Cascade Biocatalysts

Denver, CO • On-site

$110K - $150K/yr

Full-time

Re-posted 14 days ago

Job description

Job Title: Process Development Scientist, Biocatalysis
Location: Denver, CO (on-site)
Type: Full-time
Job Description:
Cascade Biocatalysts is building the next generation of industrial biocatalysts and is seeking a hands-on Process Development Scientist, Biocatalysis to join and lead our biocatalytic process development, intensification, and scale-up efforts.
This is a foundational role at Cascade Bio. You will be the person who builds our process development function, setting technical direction, establishing SOPs and standards, and owning the path from bench-scale proof of concept to a process that works at commercial scale. You will work directly with the founding team, with ownership over outcomes and the opportunity to shape not just the science but the culture and direction of the company.
The right candidate is a subject matter expert on commercial biocatalysis and is as comfortable running reactions at the bench as they are thinking about cost per kilogram and scale-up implications. The ideal candidate comes from a biocatalysis-focused company, CDMO, or industrial process chemistry group, and is now ready to bring that instinct and experience to a place where their work will have direct and visible impact.
Key Responsibilities
  • Own biocatalytic process development end-to-end, from initial hits to optimized ready to scale processes
  • Run and optimize enzymatic reactions, driving process intensification by improving space-time yield, reducing enzyme loading, extending catalyst lifetime, and lowering overall process costs
  • Collaborate with our enzyme immobilization team to evaluate and implement biocatalyst formats
  • Evaluate and implement new equipment and process analytical technology solutions
  • Lead and grow a small process development team over time, mentoring junior scientists while maintaining a technical culture and standards
  • Build and maintain techno-economic models tracking key process metrics: E-factor, PMI, catalyst cost contribution, and downstream processing implications
  • Interface with protein engineering efforts, translating process bottlenecks into enzyme engineering targets and back-integrating improved variants
  • Contribute broadly across the organization: at this stage of the company, the most impactful team members bring their expertise to problems beyond their core scope
  • Strong communication skills and ability to balance multiple priorities in a fast-paced, cross-functional and dynamic environment across a variety of programs
Qualifications
  • PhD or MS in biochemistry, chemical engineering, organic chemistry, or a related field with a strong biocatalysis or heterogeneous catalysis focus
  • Minimum of 4 years of experience in process development including scale up, continuous improvements and commercial biocatalysis development
  • Demonstrated ability to improve process performance against real commercial targets, including yield, cost, throughput, not just feasibility
  • Experience with techno-economic modeling and process analytical tools
  • Familiarity with DOE-driven development and comfort using data systematically to guide decisions
  • Experience working across disciplines, including protein engineering, analytical chemistry, and engineering, and translating between scientific and commercial priorities
  • Prior experience at a biocatalysis-focused company, CDMO, or industrial process chemistry group strongly preferred
  • Comfort operating in an early-stage environment with limited resources, ambiguity, and ambitious goals

About Cascade Biocatalysts
Cascade Bio is an equal opportunity employer. We welcome and encourage diversity in the workplace and strongly encourage candidates from all backgrounds to apply.
At Cascade Biocatalysts, we are commercializing our Body Armor for Enzymes™, a polymer science innovation that makes enzymes rugged and reliable for cost-effective biomanufacturing. Our platform unlocks the power of enzymes to replace traditional, unsustainable chemical processes and supports the buildout of a resilient and clean chemical industry.
We are a small and growing team, passionate about bridging biology and chemistry to build the future of manufacturing. If you're excited to bring enzymes out of the lab and into the world - we'd like to meet you.

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