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Downstream Process Development Scientist Jobs in Massachusetts

Actalent

Associate Scientist Downstream PD

Boston, MA

$43 - $48/hr

Associate Scientist-Downstream Process Development Join a dynamic and innovative team dedicated to advancing gene therapy processes. This role is perfect for individuals passionate about hands-on ...

New

CEDENT

Senior Scientist, Process Development

Watertown, MA · On-site

$99K - $135K/yr

We are seeking a Senior Scientist, Process Development, responsible for executing cell culture experiments, downstream processing, analyzing data, and contributing to process development projects.

Managed Staffing

Purification Scientist

Boston, MA · On-site

$44 - $46/hr

Monday-Friday | 8:00 AM-5:00 PM (40 hrs/week Position Summary Seeking an early-career Biologist / Purification Scientist to join the Downstream Process Development team in Boston, MA. This role will ...

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How much do downstream process development scientist jobs pay per hour?

As of Aug 10, 2026, the average hourly pay for downstream process development scientist in Massachusetts is $42.23, according to ZipRecruiter salary data. Most workers in this role earn between $30.96 and $50.38 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a downstream process development scientist?

To thrive as a Downstream Process Development Scientist, you need expertise in biochemistry, chemical engineering, and purification techniques, typically supported by a relevant science degree or higher. Experience with protein chromatography systems, filtration equipment, and data analysis software is highly valued, along with familiarity with GMP and regulatory requirements. Strong analytical thinking, problem-solving abilities, and effective teamwork and communication are key soft skills for this position. These competencies are crucial for optimizing manufacturing processes and ensuring the successful scale-up of biologic products in a collaborative environment.

What typical challenges might a downstream process development scientist encounter in their daily work?

Downstream Process Development Scientists often face challenges related to optimizing purification processes to achieve high yield and product purity, while maintaining efficiency and scalability. They may need to troubleshoot issues with chromatography, filtration, or product stability, sometimes under tight timelines. Working closely with cross-functional teams—including upstream development, quality control, and manufacturing—is common for resolving complex technical problems. Adaptability and continuous learning are important, as methods and equipment may evolve based on project needs and technological advancements.

What is a downstream process development scientist?

A Downstream Process Development Scientist is responsible for developing and optimizing processes to purify biological products, such as proteins, antibodies, or vaccines, after they are produced in upstream bioprocessing. They work with techniques like filtration, chromatography, and centrifugation to refine and scale up purification methods for manufacturing. Their role involves ensuring product quality, improving yields, and troubleshooting any processing challenges. Scientists in this field collaborate with cross-functional teams, including upstream development, analytical sciences, and manufacturing, to ensure efficient and scalable bioprocesses.

What are the most commonly searched types of Downstream Process Development Scientist jobs in Massachusetts? The most popular types of Downstream Process Development Scientist jobs in Massachusetts are:
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What job categories do people searching Downstream Process Development Scientist jobs in Massachusetts look for? The top searched job categories for Downstream Process Development Scientist jobs in Massachusetts are:
What cities in Massachusetts are hiring for Downstream Process Development Scientist jobs? Cities in Massachusetts with the most Downstream Process Development Scientist job openings:
Downstream Process Development Scientist jobs near you
Infographic showing various Downstream Process Development Scientist job openings in Massachusetts as of August 2026, with employment types broken down into 87% Full Time, and 13% Contract. Highlights an 94% In-person, and 6% Hybrid job distribution, with an average salary of $87,828 per year, or $42.2 per hour.

DOWNSTREAM PROCESS DEVELOPMENT SCIENTIST

MyGradJob

Billerica, MA

Full-time

Re-posted 17 days ago

Job description

Company Description

MilliporeSigma is the North American life science brand of Merck KGaA, Darmstadt, Germany - a leading science and technology company. It offers a broad range of innovative products and services to biotech and pharmaceutical drug therapies businesses. Through dedicated collaboration with the scientific and engineering communities, and as one of the top three R&D investors in the life science tools industry, the brand serves as a strategic partner to customers and helps advance the promise of life science.

Job Description
  • Design fit-for-purpose purification experiments according to the stage of development
  • Ensure scientific evaluation of impact of deviations to Downstream validation studies
  • Compile and analyze experimental data to generate process knowledge and decide on next steps
  • Write development and validation reports and ensure their timely delivery
  • Prepare and present project updates to global project team and to upper management
  • Ensure a continuous improvement within Downstream process development activities
  • Represent & promote E2E and Biodevelopment activities (presentations, congresses, events)
  • Technical lead on the overall projects (supervises Downstream processes development and implementation of new methods and services)
  • Technical leader for equipment, technologies for Downstream process development
  • Responsible for activities ranging from protein purification, filtration, biochemical and biophysical characterization of proteins: -
  • Execute routine protein purification with affinity, size exclusion, ion exchange, and hydrophobic interaction chromatography using AKTA systems (Unicorn software)
  • Perform analyses including but not limited to SDS-PAGE, SE-HPLC, LAL, host cell-DNA, host cell protein, as necessary
  • To develop, validate and transfer robust analytical methods required for successful drug development and manufacturing.
  • To support follow-up and troubleshooting on analytical methods.
  • Provide expertise and insight to guide development of appropriate purification methods
  • Develop novel purification processes as well as using standard methods to purify proteins from the mg to gram scale. Processes will be multiple steps and must provide necessary clearance of viruses, endotoxin, and host cell proteins and DNA.
  • Perform, develop and optimize robust, efficient, scalable strategies for improving process performance. Activities will include small-scale studies and pilot scale purification studies.
  • Apply DOE methods to purification activities
Qualifications
  • Engineering/Master degree (PhD preferred) in biotechnology with 5+ years in the biopharmaceutical industry
  • Solid and proven theoretical basis and hands-on experience in protein purification and analytical characterization
  • Hands-on experience with purification unit operations including filtration, chromatography, TFF, UF/DF, AKTA, UNICORN and HPLC systems.
  • Strong hands-on experience in troubleshooting and routine instrument maintenance.
  • Experienced in protein purification via affinity, hydrophobic interaction (HIC), ion exchange (IEX), size exclusion (SEC) and mixed-mode chromatography
  • Knowledge and skills in biochemical characterization of proteins including analytical and biophysical
  • Proven track record in Purification Process Development is necessary with emphasis on chromatographic separations and excellent understanding of and experience with chromatographic resin screening and process optimization.  Experience with scale-up and GMP manufacturing is desirable.
  • Solid and proven working knowledge of DOE. Ability to critically analyze data using statistical tools and to compile technical reports
  • Excellent presentation and communication skills
  • Results-oriented with ability to work and deliver under pressure
  • Excellent English (written, oral) 
Additional Information

All your information will be kept confidential according to EEO guidelines.

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