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Downstream Process Development Scientist Jobs in Massachusetts

Amgen

Process Development Senior Scientist

Cambridge, MA · On-site

$100K - $136K/yr

Process Development Senior Scientist What you will do Let'sdo this.Let'schange the world. In this vital role you willbe responsible fordevelopment, characterization, scale-up and support of drug ...

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Downstream Process Development Scientist information

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$22

$42

$67

How much do downstream process development scientist jobs pay per hour?

As of Aug 11, 2026, the average hourly pay for downstream process development scientist in Massachusetts is $42.23, according to ZipRecruiter salary data. Most workers in this role earn between $30.96 and $50.38 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a downstream process development scientist?

To thrive as a Downstream Process Development Scientist, you need expertise in biochemistry, chemical engineering, and purification techniques, typically supported by a relevant science degree or higher. Experience with protein chromatography systems, filtration equipment, and data analysis software is highly valued, along with familiarity with GMP and regulatory requirements. Strong analytical thinking, problem-solving abilities, and effective teamwork and communication are key soft skills for this position. These competencies are crucial for optimizing manufacturing processes and ensuring the successful scale-up of biologic products in a collaborative environment.

What typical challenges might a downstream process development scientist encounter in their daily work?

Downstream Process Development Scientists often face challenges related to optimizing purification processes to achieve high yield and product purity, while maintaining efficiency and scalability. They may need to troubleshoot issues with chromatography, filtration, or product stability, sometimes under tight timelines. Working closely with cross-functional teams—including upstream development, quality control, and manufacturing—is common for resolving complex technical problems. Adaptability and continuous learning are important, as methods and equipment may evolve based on project needs and technological advancements.

What is a downstream process development scientist?

A Downstream Process Development Scientist is responsible for developing and optimizing processes to purify biological products, such as proteins, antibodies, or vaccines, after they are produced in upstream bioprocessing. They work with techniques like filtration, chromatography, and centrifugation to refine and scale up purification methods for manufacturing. Their role involves ensuring product quality, improving yields, and troubleshooting any processing challenges. Scientists in this field collaborate with cross-functional teams, including upstream development, analytical sciences, and manufacturing, to ensure efficient and scalable bioprocesses.

What are the most commonly searched types of Downstream Process Development Scientist jobs in Massachusetts? The most popular types of Downstream Process Development Scientist jobs in Massachusetts are:
What are popular job titles related to Downstream Process Development Scientist jobs in Massachusetts? For Downstream Process Development Scientist jobs in Massachusetts, the most frequently searched job titles are:
What job categories do people searching Downstream Process Development Scientist jobs in Massachusetts look for? The top searched job categories for Downstream Process Development Scientist jobs in Massachusetts are:
What cities in Massachusetts are hiring for Downstream Process Development Scientist jobs? Cities in Massachusetts with the most Downstream Process Development Scientist job openings:
Downstream Process Development Scientist jobs near you
Infographic showing various Downstream Process Development Scientist job openings in Massachusetts as of August 2026, with employment types broken down into 91% Full Time, and 9% Contract. Highlights an 95% In-person, and 5% Hybrid job distribution, with an average salary of $87,828 per year, or $42.2 per hour.

Process Development Research Scientist

Massachusetts General Hospital

Boston, MA • On-site

$60K - $96K/yr

Other

This job post has expired today. Applications are no longer accepted.

Massachusetts General Hospital rating

7.7

Company rating: 7.7 out of 10

Based on 44 frontline employees who took The Breakroom Quiz

221st of 1,056 rated hospitals

Job description

Site: The General Hospital Corporation


Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.


Job Summary

In consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication. Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary.
Does this position require Patient Care? No
Essential Functions
-Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field.
-Contributes to the design and execution of experiments and/or research projects.
-Exercises judgment in selecting methods and technologies to obtain results.
-May collaborate with external researchers and/or receive external project funding support.
-Presents results and prepares publications.
-May assist PI in the training and supervision of other staff.


Qualifications

Job Description

Education Doctorate Related Field of Study required
Can this role accept experience in lieu of a degree? No
Licenses and Credentials
Experience
Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required
Knowledge, Skills and Abilities
- Excellent research skills.
- Demonstrated evidence of specific scientific competence in field.
- Demonstrated broad knowledge of field.
- Evidence of potential for scientific creativity and original though.
- Able to exercise independent judgment and leadership.
- Ability to contribute to publications.


Additional Job Details (if applicable)

The Massachusetts General Hospital Cancer Center's Process Development Laboratory seeks a full-time Process Development Scientist I to support and advance its translational cell and gene therapy research platform. The Process Development Laboratory is a highly integrated, innovation-driven facility dedicated to translating next-generation cellular immunotherapy and gene engineering technologies into clinically deployable manufacturing solutions. This position offers an exceptional opportunity for an independent and motivated scientist to serve as a scientific lead within a multidisciplinary translational team, working at the interface of biology, engineering, manufacturing science, and regulatory strategy.

The successful candidate will contribute to the design, development, optimization, and clinical translation of novel manufacturing workflows poised for IND-enabling studies and early-phase clinical trials, while operating in a collaborative academic medical center environment.

Preferred Qualifications:

* Demonstrated experience in cell and/or gene therapy research and process development.

* Hands-on experience working with primary human cells, preferably immune effector cells.

* Strong foundation in cell culture, molecular biology, and translational experimental design.

* Experience with CAR T-cell or immune effector cell manufacturing.

* Familiarity with CRISPR/Cas-based genome editing technologies.

* Experience with viral vector production or gene delivery platforms.

* Exposure to cGMP environments, IND-enabling studies, or regulated manufacturing settings.

* Experience with closed-system or automated manufacturing platforms.

* Prior experience contributing to regulatory documentation, technology transfer, or validation activities.

The salary range for this position is $60,000.00 to $96,000.00 annually. At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience, if applicable, education, certifications, and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package.

In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums, and bonuses as applicable, and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.


Remote Type

Onsite


Work Location

149 Thirteenth Street Building 149


Scheduled Weekly Hours

40


Employee Type

Regular


Work Shift

Day (United States of America)


EEO Statement:

1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.


Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

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About Massachusetts General Hospital

Sourced by ZipRecruiter

Mass General has the largest hospital based research program in the U.S. Guided by the needs of our patients, Mass General delivers care grounded in leading edge research, advanced treatment offerings and the latest clinical trials. Massachusetts General Hospital was established to provide care to Boston's sick, regardless of socioeconomic status, and became the first teaching hospital of Harvard University's new medical school. We have remained at the forefront of medicine by fostering a culture of collaboration and education, pushing the boundaries of medical research, and maintaining an unwavering commitment to the diverse community we were created to serve. We believe that because of diversity we excel, through inclusion we respect our community, and with a keen focus on equity we serve, heal, educate and innovate at the highest levels. Our first priority is the well-being of our patients—near and far. As a team we are able to maintain a singular focus on providing the highest quality, most compassionate care to each and every patient.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Boston, MA, US

Year founded

1811

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