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How much do downstream process development scientist jobs pay per hour?

As of Aug 2, 2026, the average hourly pay for downstream process development scientist in New York is $42.30, according to ZipRecruiter salary data. Most workers in this role earn between $31.01 and $50.48 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Process Development Scientist position, and why are they important?

To thrive as a Downstream Process Development Scientist, you need expertise in biochemistry, chemical engineering, and purification techniques, typically supported by a relevant science degree or higher. Experience with protein chromatography systems, filtration equipment, and data analysis software is highly valued, along with familiarity with GMP and regulatory requirements. Strong analytical thinking, problem-solving abilities, and effective teamwork and communication are key soft skills for this position. These competencies are crucial for optimizing manufacturing processes and ensuring the successful scale-up of biologic products in a collaborative environment.

What typical challenges might a Downstream Process Development Scientist encounter in their daily work?

Downstream Process Development Scientists often face challenges related to optimizing purification processes to achieve high yield and product purity, while maintaining efficiency and scalability. They may need to troubleshoot issues with chromatography, filtration, or product stability, sometimes under tight timelines. Working closely with cross-functional teams—including upstream development, quality control, and manufacturing—is common for resolving complex technical problems. Adaptability and continuous learning are important, as methods and equipment may evolve based on project needs and technological advancements.

What is a Downstream Process Development Scientist job?

A Downstream Process Development Scientist is responsible for developing and optimizing processes to purify biological products, such as proteins, antibodies, or vaccines, after they are produced in upstream bioprocessing. They work with techniques like filtration, chromatography, and centrifugation to refine and scale up purification methods for manufacturing. Their role involves ensuring product quality, improving yields, and troubleshooting any processing challenges. Scientists in this field collaborate with cross-functional teams, including upstream development, analytical sciences, and manufacturing, to ensure efficient and scalable bioprocesses.

What are the most commonly searched types of Downstream Process Development Scientist jobs in New York? The most popular types of Downstream Process Development Scientist jobs in New York are:
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Downstream Process Development Scientist jobs near you
Infographic showing various Downstream Process Development Scientist job openings in New York as of July 2026, with employment types broken down into 90% Full Time, and 10% Contract. Highlights an 94% In-person, and 6% Hybrid job distribution, with an average salary of $87,982 per year, or $42.3 per hour.

Principal Scientist, Lentivirus Downstream Process Development

Legend Biotech US

Somerset, NJ • Hybrid

Other

Re-posted 5 days ago

Job description

Legend Biotech is seeking a Principal Scientist, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ.

Role Overview

The Principal Scientist, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in downstream processing (DSP)-including clarification, chromatography, TFF, sterile filtration and fill/finish-ensuring processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strategic thinking to accelerate timelines while maintaining a patient-focused approach.

Key Responsibilities

  • Design and execute highly efficient purification strategies for lentiviral vectors, specifically optimized for CAR-T applications.
  • Direct the development and optimization of downstream processes including and not limited to: clarification (depth filtration, centrifugation), chromatography (AEX, SEC, HIC), and Tangential Flow Filtration (TFF) for concentration and diafiltration.
  • Provide hands-on training as needed.
  • Direct the translation of bench-scale processes to GMP manufacturing, ensuring seamless technology transfer and providing troubleshooting support during clinical production runs
  • Lead the execution of study protocols to define operating parameters and performance limits; implement state-of-the-art knowledge management for DSP data.
  • Communicate the potential for issues and delays along with solutions and mitigation approaches.
  • In collaboration with the Senior Leaders, CMC Project Manager, Project Leader, and other technical leads identify project acceleration opportunities.
  • Leverage advanced science and technology to maximize vector recovery, purity, and potency, identifying creative solutions to define unknowns in the viral vector field.
  • Guide a team of scientists in the execution of project-specific activities, fostering a culture of transparency, scientific rigor, and continuous improvement.
  • Author and serve as a primary reviewer for technical documents, including development reports, SOPs, and CMC sections for regulatory submissions (IND/IMPD).
  • Work closely with Upstream Process Development and Analytical Development teams to ensure integrated and holistic process outcomes.
  • Tech transfer process to/from other Legend sites or CDMOs
  • Resolve conflict and proactively identify/address performance issues.
  • Ensure compliance with regulatory requirements. 

Requirements

  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, Virology, Molecular Biology, or a related field.
  • 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
  • Deep technical hands-on experience in purification, chromatography, and TFF specifically for viral vectors (Lentivirus preferred)
  • Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
  • Deep knowledge and hands-on experiences in cell and lentiviral vector technologies within the current emerging field
  • Ability to implement closed-system processes and maximize cost effectiveness
  • Strong knowledge in engineering modeling and optimization.
  • Excellent leadership, emotional intelligence, and communication skills; ability to maintain composure and strategic focus during challenging development timelines.
  • Creative, strategic thinking
  • Strong troubleshooting skills
  • Preferred experience in developing vector processes tailored for CAR-T generation and systemic delivery
  • Preferred experience in handling large scale(>50L) purification process.
  • Language: English. Mandarin is a plus. 

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