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Full Time Downstream Process Development Scientist Jobs

Legend Biotech USA, Inc.

Role OverviewThe Principal Scientist, Lentivirus Downstream Process Development, will be a key ... These benefits are offered exclusively to permanent full-time employees. Contractors are not ...

Avidity NanoMedicines

Principal Scientist, Biologics Process Development At Avidity Biosciences, we are passionate about ... This role will serve as the technical lead for downstream process development activities across ...

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How much do full time downstream process development scientist jobs pay per hour?

As of May 28, 2026, the average hourly pay for full time downstream process development scientist in the United States is $38.66, according to ZipRecruiter salary data. Most workers in this role earn between $28.37 and $46.15 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Full Time Downstream Process Development Scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.

What are some typical challenges faced by a Downstream Process Development Scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What does a Full Time Downstream Process Development Scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

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Full Time Downstream Process Development Scientist jobs near you
Infographic showing various Full Time Downstream Process Development Scientist job openings in the United States as of May 2026, with employment types broken down into 1% As Needed, 90% Full Time, 8% Part Time, and 1% Contract. Highlights an 13% Hybrid, and 87% Remote job distribution, with an average salary of $80,420 per year, or $38.7 per hour.
Downstream Process Development Associate Scientist

Downstream Process Development Associate Scientist

KBI Biopharma, Inc.

Boulder, CO • On-site

$85.76K - $117.92K/yr

Full-time

Posted 14 days ago

Job description

JOB SUMMARY
The Downstream Process Development (PD) Associate Scientist provides process development input and co-ownership for a product, including all development and design decisions, with oversight and mentorship from senior process development staff. They learn to apply scientific principles to design and execute laboratory studies for unit operation development and optimization. They possess a developing working knowledge of the downstream functional area with developing aptitude in one or more operations, including chromatography and tangential flow filtration. They author and review technical documents including protocols and reports commensurate with PD compliance and quality standards. This workflow encompasses process development scope as well as support of technology transfer activities in preparation for cGMP production. The PD Scientist I is responsible for maintaining training compliance, according to site expectations. This is a salaried exempt position, with the expectation to cover shift work as needed to support laboratory activities and organizational need.
Responsibilities
  • Executes process development, process characterization, and technology transfer of microbial processes to commercial cGMP facility.
  • Works toward developing a broad knowledge of state-of-the-art principles and theory.
  • Responsible for producing high quality documentation and client reports suitable for publication and regulatory requirements. Compiles and presents data to clients.
  • Supports downstream process development efforts in the laboratory and manufacturing areas. Executes experiments with oversight and support. Conceptualizes and proposes process development and manufacturing based on process data. Execution includes downstream unit operations such as chromatography, tangential flow filtration, normal filtration, as well as sampling and basic analysis of process samples; concentration, pH, and conductivity.
  • Will assist in the downstream portion of development, process characterization, and/or technology transfer programs.
  • Provide technical support for cGMP manufacturing through floor coverage, batch document review, and support of deviations and change controls with mentor/managerial oversight.
  • Responsible for developing/maintaining a current understanding of cGMP and other regulatory requirements.
  • Documents procedures, observations, and results in laboratory notebooks and responsible for maintaining training compliance, according to site expectation. Reviews documentation and records as assigned.
  • May contribute to the evaluation, development and implementation of new downstream technologies leading to process improvements and efficiency of operation in support of downstream process development and manufacturing activities.
  • Adheres to all safety requirements and assures that departmental employees comply with required safety procedures.
  • Reacts to change productively and handles other essential tasks as assigned

REQUIREMENTS
B.S. degree and a minimum of 5+ years of related experience; M.S. and 3+ years of related experience or Ph.D. and 0+ years related experience in a scientific discipline.
Experience with downstream process development and chromatography equipment required. Excellent written and verbal communication skills, focus on customer service, and ability to meet strict client deadlines. Highly collaborative. Flexibility of hours to support downstream processes. Knowledge of GMPs and biotechnology-derived product regulations preferred.
Salary: $85,760-$117,920
KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.
I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.
I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.

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