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How much do full time downstream process development scientist jobs pay per hour?

As of Jul 10, 2026, the average hourly pay for full time downstream process development scientist in the United States is $38.66, according to ZipRecruiter salary data. Most workers in this role earn between $28.37 and $46.15 per hour, depending on experience, location, and employer.

What does a Full Time Downstream Process Development Scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

What are some typical challenges faced by a Downstream Process Development Scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What are the key skills and qualifications needed to thrive as a Full Time Downstream Process Development Scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.
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Full Time Downstream Process Development Scientist jobs near you
Downstream Process Development Scientist I

Downstream Process Development Scientist I

Wheeler Bio, Inc.

Oklahoma City, OK • On-site

Full-time

Posted 24 days ago

Job description

Location: Oklahoma City, OK
Department: Process Development
Job Type: Full-Time

Position Overview:

We are seeking an experienced and highly motivated Biotech Process Development Scientist I to join our innovative team. This role will focus on advanced process development, optimization, and scale-up of bioprocesses for the production of biologics and therapeutic products. As a Downstream Process Development Scientist I, you will work independently and as part of a multidisciplinary team to drive the development of robust, scalable processes while collaborating with other departments to ensure project success.

Key Responsibilities:

· Independently design, optimize, and execute experiments to advance bioprocesses for downstream operations, including monoclonal antibodies, Fc-fusion proteins, bispecific antibodies, and cytokines.

· Lead the development and scale-up of bioprocesses from laboratory-scale through to pilot-scale and provide technical expertise for technology transfer to commercial manufacturing for clarification, chromatography (including affinity, ion exchange, hydrophobic interaction and mixed-mode), viral inactivation and viral filtration, ultra-filtration/diafiltration and filtration unit operations and process steps.

· Manage and execute viral clearance studies.

· Assist in the optimization of downstream bioprocess parameters for yield, purity, and product quality attributes, collaborating with upstream, analytical and formulation teams.

· Troubleshoot and resolve complex technical challenges by analyzing process data, performing root cause analysis, and implementing corrective actions.

· Collaborate with cross-functional teams, including Upstream and Analytical Development, Quality Assurance, MSAT, and Manufacturing to ensure the successful progression of projects.

· Lead the preparation and review of detailed technical documentation, including experimental protocols, reports, standard operating procedures (SOPs), and regulatory filings.

· Monitor and ensure compliance with industry regulations, including Good Laboratory Practices (GLP), Good Manufacturing Practices (GMP), and FDA guidelines throughout the process development lifecycle.

· Provide mentorship and guidance to junior team members, helping to develop their skills and knowledge in bioprocess development.

· Plan and execute experiments in a timely manner, ensuring all milestones and timelines are met.

· Prepare presentations for internal stakeholders and regulatory authorities to communicate process development progress, challenges, and solutions.

· Contribute to the preparation of process development budgets and timelines, and track project deliverables against established goals.

Qualifications:

  • Bachelor’s degree in Biological Sciences, Chemical Engineering, Biotechnology, or a related field. A Master’s degree or Ph.D. is a plus.
  • Minimum of 4-6 years of experience in bioprocess development, preferably within a biotech, pharmaceutical, or biologics manufacturing environment.
  • Strong hands-on experience with purification techniques, viral clearance, and process characterization.
  • Expertise in process development strategies for scaling up from laboratory to pilot scale and facilitating technology transfer to manufacturing.
  • Proficiency with process analytical technologies (PAT), and experience with downstream purification equipment, and chromatography techniques.
  • Strong understanding of regulatory requirements, including GMP, GLP, FDA, and ICH guidelines.
  • Experience in AKTA purification systems and UNICORN software and liquid handling platforms is preferred.
  • Proficiency in data analysis and process modeling using software tools such as Excel, JMP, GraphPad, or similar platforms.
  • Strong problem-solving, troubleshooting, and critical-thinking skills with the ability to manage multiple projects simultaneously.
  • Excellent written and verbal communication skills, with the ability to convey complex technical concepts to both technical and non-technical stakeholders.
  • Proven ability to work effectively both independently and in a team-oriented, collaborative environment.

Physical Requirements:

· Ability to perform lab-based tasks, including standing for long periods, working with various laboratory equipment, and handling biological samples.

· Must be able to lift and carry equipment, reagents, and materials weighing up to 25 pounds.

Working Conditions:

  • This position requires flexibility in working hours, including potential shift work, weekends, and on-call duties as necessary.
  • Work involves the handling of biological materials.