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How much do associate downstream process development scientist jobs pay per hour?

As of Jun 20, 2026, the average hourly pay for associate downstream process development scientist in the United States is $33.68, according to ZipRecruiter salary data. Most workers in this role earn between $27.64 and $41.35 per hour, depending on experience, location, and employer.

What is an Associate Downstream Process Development Scientist?

An Associate Downstream Process Development Scientist is a professional who works in the biotechnology or pharmaceutical industry, focusing on developing and optimizing processes that purify biological products, such as proteins or antibodies, after they have been produced by cells. Their work is crucial for ensuring the final product meets quality and safety standards before it is used in research or clinical applications. They typically perform laboratory experiments, analyze data, and collaborate with other scientists and engineers to improve yield and efficiency. This role is often entry-level or early-career, providing hands-on experience in process development and technical troubleshooting.

What are the key skills and qualifications needed to thrive as an Associate Downstream Process Development Scientist, and why are they important?

To excel as an Associate Downstream Process Development Scientist, you need a solid understanding of biochemistry, chemical engineering, and downstream purification techniques, often supported by a bachelor's or master's degree in a life science or engineering discipline. Familiarity with chromatographic systems (such as AKTA), filtration equipment, and analytical tools, as well as knowledge of GMP/GLP regulations, is typically required. Strong problem-solving, attention to detail, and effective teamwork and communication skills help you navigate complex experiments and collaborate with cross-functional teams. These skills ensure efficient process optimization, compliance with regulatory standards, and successful development of biopharmaceutical products.

What is the difference between Associate Downstream Process Development Scientist vs Associate Upstream Process Development Scientist?

AspectAssociate Downstream Process Development ScientistAssociate Upstream Process Development Scientist
Primary FocusPurification and recovery of bioproductsCell culture and fermentation processes
Required SkillsProtein purification, chromatography, filtrationCell culture, bioreactor operation, media preparation
Work EnvironmentLaboratories, manufacturing facilitiesLaboratories, bioreactor labs
Common CertificationsBiotech or bioprocessing certificationsBiotech or bioprocessing certifications

Both roles are essential in biopharmaceutical development, focusing on different stages of the production process. The Associate Downstream Process Development Scientist specializes in purification techniques, while the Associate Upstream Process Development Scientist concentrates on cell growth and fermentation. Understanding these distinctions helps candidates target their skills and career paths effectively.

What are some typical challenges faced by an Associate Downstream Process Development Scientist, and how can they be addressed?

Associate Downstream Process Development Scientists often encounter challenges such as optimizing purification processes, troubleshooting equipment performance, and ensuring batch-to-batch consistency. These challenges can be addressed by maintaining meticulous documentation, collaborating closely with upstream and analytical teams, and staying current with best practices in chromatography and filtration. Proactively seeking feedback from experienced colleagues and participating in cross-functional meetings can also help in identifying solutions and improving process efficiency.
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Associate Downstream Process Development Scientist jobs near you
Downstream Process Development Scientist I

Downstream Process Development Scientist I

Wheeler Bio, Inc.

Oklahoma City, OK • On-site

Full-time

Posted 4 days ago

Job description

Location: Oklahoma City, OK
Department: Process Development
Job Type: Full-Time

Position Overview:

We are seeking an experienced and highly motivated Biotech Process Development Scientist I to join our innovative team. This role will focus on advanced process development, optimization, and scale-up of bioprocesses for the production of biologics and therapeutic products. As a Downstream Process Development Scientist I, you will work independently and as part of a multidisciplinary team to drive the development of robust, scalable processes while collaborating with other departments to ensure project success.

Key Responsibilities:

· Independently design, optimize, and execute experiments to advance bioprocesses for downstream operations, including monoclonal antibodies, Fc-fusion proteins, bispecific antibodies, and cytokines.

· Lead the development and scale-up of bioprocesses from laboratory-scale through to pilot-scale and provide technical expertise for technology transfer to commercial manufacturing for clarification, chromatography (including affinity, ion exchange, hydrophobic interaction and mixed-mode), viral inactivation and viral filtration, ultra-filtration/diafiltration and filtration unit operations and process steps.

· Manage and execute viral clearance studies.

· Assist in the optimization of downstream bioprocess parameters for yield, purity, and product quality attributes, collaborating with upstream, analytical and formulation teams.

· Troubleshoot and resolve complex technical challenges by analyzing process data, performing root cause analysis, and implementing corrective actions.

· Collaborate with cross-functional teams, including Upstream and Analytical Development, Quality Assurance, MSAT, and Manufacturing to ensure the successful progression of projects.

· Lead the preparation and review of detailed technical documentation, including experimental protocols, reports, standard operating procedures (SOPs), and regulatory filings.

· Monitor and ensure compliance with industry regulations, including Good Laboratory Practices (GLP), Good Manufacturing Practices (GMP), and FDA guidelines throughout the process development lifecycle.

· Provide mentorship and guidance to junior team members, helping to develop their skills and knowledge in bioprocess development.

· Plan and execute experiments in a timely manner, ensuring all milestones and timelines are met.

· Prepare presentations for internal stakeholders and regulatory authorities to communicate process development progress, challenges, and solutions.

· Contribute to the preparation of process development budgets and timelines, and track project deliverables against established goals.

Qualifications:

  • Bachelor’s degree in Biological Sciences, Chemical Engineering, Biotechnology, or a related field. A Master’s degree or Ph.D. is a plus.
  • Minimum of 4-6 years of experience in bioprocess development, preferably within a biotech, pharmaceutical, or biologics manufacturing environment.
  • Strong hands-on experience with purification techniques, viral clearance, and process characterization.
  • Expertise in process development strategies for scaling up from laboratory to pilot scale and facilitating technology transfer to manufacturing.
  • Proficiency with process analytical technologies (PAT), and experience with downstream purification equipment, and chromatography techniques.
  • Strong understanding of regulatory requirements, including GMP, GLP, FDA, and ICH guidelines.
  • Experience in AKTA purification systems and UNICORN software and liquid handling platforms is preferred.
  • Proficiency in data analysis and process modeling using software tools such as Excel, JMP, GraphPad, or similar platforms.
  • Strong problem-solving, troubleshooting, and critical-thinking skills with the ability to manage multiple projects simultaneously.
  • Excellent written and verbal communication skills, with the ability to convey complex technical concepts to both technical and non-technical stakeholders.
  • Proven ability to work effectively both independently and in a team-oriented, collaborative environment.

Physical Requirements:

· Ability to perform lab-based tasks, including standing for long periods, working with various laboratory equipment, and handling biological samples.

· Must be able to lift and carry equipment, reagents, and materials weighing up to 25 pounds.

Working Conditions:

  • This position requires flexibility in working hours, including potential shift work, weekends, and on-call duties as necessary.
  • Work involves the handling of biological materials.