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Associate Downstream Process Development Scientist Jobs in Worcester, MA

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Associate Downstream Process Development Scientist information

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$18

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$49

How much do associate downstream process development scientist jobs pay per hour?

As of Jul 15, 2026, the average hourly pay for associate downstream process development scientist in Worcester, MA is $33.61, according to ZipRecruiter salary data. Most workers in this role earn between $27.60 and $41.25 per hour, depending on experience, location, and employer.

What is an Associate Downstream Process Development Scientist?

An Associate Downstream Process Development Scientist is a professional who works in the biotechnology or pharmaceutical industry, focusing on developing and optimizing processes that purify biological products, such as proteins or antibodies, after they have been produced by cells. Their work is crucial for ensuring the final product meets quality and safety standards before it is used in research or clinical applications. They typically perform laboratory experiments, analyze data, and collaborate with other scientists and engineers to improve yield and efficiency. This role is often entry-level or early-career, providing hands-on experience in process development and technical troubleshooting.

What are the key skills and qualifications needed to thrive as an Associate Downstream Process Development Scientist, and why are they important?

To excel as an Associate Downstream Process Development Scientist, you need a solid understanding of biochemistry, chemical engineering, and downstream purification techniques, often supported by a bachelor's or master's degree in a life science or engineering discipline. Familiarity with chromatographic systems (such as AKTA), filtration equipment, and analytical tools, as well as knowledge of GMP/GLP regulations, is typically required. Strong problem-solving, attention to detail, and effective teamwork and communication skills help you navigate complex experiments and collaborate with cross-functional teams. These skills ensure efficient process optimization, compliance with regulatory standards, and successful development of biopharmaceutical products.

What is the difference between Associate Downstream Process Development Scientist vs Associate Upstream Process Development Scientist?

AspectAssociate Downstream Process Development ScientistAssociate Upstream Process Development Scientist
Primary FocusPurification and recovery of bioproductsCell culture and fermentation processes
Required SkillsProtein purification, chromatography, filtrationCell culture, bioreactor operation, media preparation
Work EnvironmentLaboratories, manufacturing facilitiesLaboratories, bioreactor labs
Common CertificationsBiotech or bioprocessing certificationsBiotech or bioprocessing certifications

Both roles are essential in biopharmaceutical development, focusing on different stages of the production process. The Associate Downstream Process Development Scientist specializes in purification techniques, while the Associate Upstream Process Development Scientist concentrates on cell growth and fermentation. Understanding these distinctions helps candidates target their skills and career paths effectively.

What are some typical challenges faced by an Associate Downstream Process Development Scientist, and how can they be addressed?

Associate Downstream Process Development Scientists often encounter challenges such as optimizing purification processes, troubleshooting equipment performance, and ensuring batch-to-batch consistency. These challenges can be addressed by maintaining meticulous documentation, collaborating closely with upstream and analytical teams, and staying current with best practices in chromatography and filtration. Proactively seeking feedback from experienced colleagues and participating in cross-functional meetings can also help in identifying solutions and improving process efficiency.
What are the most commonly searched types of Downstream Process Development Scientist jobs in Worcester, MA? The most popular types of Downstream Process Development Scientist jobs in Worcester, MA are:
What cities near Worcester, MA are hiring for Associate Downstream Process Development Scientist jobs? Cities near Worcester, MA with the most Associate Downstream Process Development Scientist job openings:
Associate Downstream Process Development Scientist jobs near you

Process Manager - Downstream Process Development

Rentschler

Milford, MA • On-site

Full-time

Medical, Retirement

Posted 16 hours ago

Job description

Advancing medicine to save lives. Together.
Thanks to many decades of experience and our passion for what we do, we make an essential contribution to the global availability of biopharmaceuticals, especially for patients with rare and serious diseases.
Rentschler Biopharma SE is a leading contract development and manufacturing organization (CDMO) focused exclusively on client projects. We offer customized full-service solutions for bioprocess development and the production of complex biopharmaceuticals. As a German family-owned company with an international footprint and global reach, we combine experts, expertise and years of experience to develop best-in-class solutions - together with our clients.
Rentschler Biopharma has approximately 1,400 employees and is headquartered in Laupheim, Germany, with a site in Milford, MA, USA. In 2024, we joined the United Nations Global Compact, underlining our commitment to sustainability.
As an independent family-owned company, we live by the motto: Many hands, many minds - ONE TEAM! Open, respectful cooperation characterizes our working environment, where quality awareness, diligence and responsibility are our top priorities. With all the diversity of our talents in the Rentschler team, we pursue one vision together: advancing medicine to save lives.
We are seeking a proactive, strategic, and hands-on DSP Process Manager. They will demonstrate flexibility, adaptability, and can effectively work in a fast paced, rapidly changing CDMO environment. They are self-motivated, accountable, inquisitive, and have excellent organizational and communication skills. They can multi-task while delivering excellent customer service.
The Process Manager in the Downstream Process Development group is a functional project(s) lead, who independently designs, executes, and support biologics downstream purification processes including technology transfer activities both from the client(s) and internally to the GMP manufacturing facility.
Duties and Responsibilities
  • Develop scale-able and robust downstream processes for clinical and commercial GMP manufacturing.
    • Design experiments related to development, optimization, scale-up of all steps of various recombinant protein formats (e.g., antibodies, bispecific and enzymes) inclusive of viral clearance studies.
    • Lead lab team members in the execution of experiments.
    • Apply DoE and other advanced statistical techniques to design and evaluate late-stage development activities and process characterization studies in preparation for process qualification and validation at manufacturing scale.
    • Define the control strategy for commercial manufacturing.
  • Interface with clients.
    • Analyze, prepare, and formally present data.
    • Author and collaborate on client-approved documents.
    • Provide technical consulting as a Subject Matter Expert.
  • Transfer programs to Manufacturing.
    • Provide process descriptions and gap analyses.
    • Collaborate with MSAT on change controls, deviations, and investigations.
    • Support Manufacturing and MSAT as process Subject Matter Expert, including on floor support.
  • Author high-quality documents.
    • Experimental protocols, technical reports, risk/gap assessments, SOPs, and facility fit assessments.
    • Assist with and review relevant chapters of CMC dossier sections for IND/IMPD and BLA/MAA.
    • Process and Subject Matter Expert review on batch records.
  • Lead, train, and mentor junior lab staff.
  • Identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding.
    • Contribute to the overall operations of process sciences lab and infrastructure improvements.
  • Active contributor/connector on harmonization and alliance of concepts, procedures, techniques, and documentation within international sites of the company
  • Serve as Process Science representative and participate in cross functional meetings.

Qualifications
  • Years of experience and education (one of the following):
  • A university degree and 5-8+ years of related experience
  • A Master's degree and 3-5+ years
  • A PhD and 1-3+ years of experience
  • Expertise in chromatographic processes, filtration techniques, protein chemistry, and associated analytical methods
  • Expertise in scale-up/scale-down principles as well as the use of statistical tools for data analysis and DoE
  • Experience in process characterization, qualification/validation (PPQ) and/or continued process verification (CPV) is preferred
  • Experience in viral clearance validation and scale down validation is preferred
  • Advanced proficiency with required software - Unicorn, JMP/MODDE, Word, Excel, PowerPoint
  • The candidate must demonstrate critical thinking, be self-motivated, accountable, inquisitive, have excellent organization and communication skills, and demonstrates the ability to work both independently and as a member of local and global teams
  • Excellent customer service skills and ability to meet client project deadlines
  • Basic knowledge of project management
  • Flexibility of hours to support process development or MFG floor activities over weekends and holidays; weekend and holiday hours are compensated per company policies
  • Flexibility to switch between projects

Working Conditions
  • Laboratory and manufacturing clean-room environments working with chemical reagents and processing equipment
  • Compliance with Personal Protective Equipment, clean room gowning, and EH&S requirements
  • Normal office working conditions: computer, phone, files, printer, etc
  • Interaction with people in the lab, other departments, and clients
  • Fast-paced environment with job completion deadlines

Physical Requirements
  • Frequent lifting up to 10 lbs
  • Sitting for extended periods for computer-based work
  • Standing/walking to work in lab environment for extended periods

Base Pay Range
$120,000 - $145,000
Disclosure Statement
Rentschler Biopharma, Inc is committed to fair and equitable compensation practices. The base pay range listed for this position is the anticipated annual base salary range the organization reasonably, and in good faith, expects to pay for this position at this time. Actual compensation is determined based on several factors that may include seniority, education, training, relevant experience, relevant certifications, geography of work location, job responsibilities, or other application factors permissible by law. The annual base salary is just one component of our Total Rewards package, which also includes our annual discretionary bonus program, medical insurance, our generous 401K program, plus a host of other benefits to aligned to support our employees' personal and professional wellness. The salary pay range is subject to change and may be modified at any time.

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