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Associate Downstream Process Development Scientist Jobs in California

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Cell Line Development

Tustin, CA · On-site

As a Cell Line Development Scientist, you will play a critical role in establishing high-performing ... Partner with Upstream and Downstream Process Development and Analytical teams to deliver integrated ...

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Associate Downstream Process Development Scientist information

What is an Associate Downstream Process Development Scientist?

An Associate Downstream Process Development Scientist is a professional who works in the biotechnology or pharmaceutical industry, focusing on developing and optimizing processes that purify biological products, such as proteins or antibodies, after they have been produced by cells. Their work is crucial for ensuring the final product meets quality and safety standards before it is used in research or clinical applications. They typically perform laboratory experiments, analyze data, and collaborate with other scientists and engineers to improve yield and efficiency. This role is often entry-level or early-career, providing hands-on experience in process development and technical troubleshooting.

What are the key skills and qualifications needed to thrive as an Associate Downstream Process Development Scientist, and why are they important?

To excel as an Associate Downstream Process Development Scientist, you need a solid understanding of biochemistry, chemical engineering, and downstream purification techniques, often supported by a bachelor's or master's degree in a life science or engineering discipline. Familiarity with chromatographic systems (such as AKTA), filtration equipment, and analytical tools, as well as knowledge of GMP/GLP regulations, is typically required. Strong problem-solving, attention to detail, and effective teamwork and communication skills help you navigate complex experiments and collaborate with cross-functional teams. These skills ensure efficient process optimization, compliance with regulatory standards, and successful development of biopharmaceutical products.

What is the difference between Associate Downstream Process Development Scientist vs Associate Upstream Process Development Scientist?

AspectAssociate Downstream Process Development ScientistAssociate Upstream Process Development Scientist
Primary FocusPurification and recovery of bioproductsCell culture and fermentation processes
Required SkillsProtein purification, chromatography, filtrationCell culture, bioreactor operation, media preparation
Work EnvironmentLaboratories, manufacturing facilitiesLaboratories, bioreactor labs
Common CertificationsBiotech or bioprocessing certificationsBiotech or bioprocessing certifications

Both roles are essential in biopharmaceutical development, focusing on different stages of the production process. The Associate Downstream Process Development Scientist specializes in purification techniques, while the Associate Upstream Process Development Scientist concentrates on cell growth and fermentation. Understanding these distinctions helps candidates target their skills and career paths effectively.

What are some typical challenges faced by an Associate Downstream Process Development Scientist, and how can they be addressed?

Associate Downstream Process Development Scientists often encounter challenges such as optimizing purification processes, troubleshooting equipment performance, and ensuring batch-to-batch consistency. These challenges can be addressed by maintaining meticulous documentation, collaborating closely with upstream and analytical teams, and staying current with best practices in chromatography and filtration. Proactively seeking feedback from experienced colleagues and participating in cross-functional meetings can also help in identifying solutions and improving process efficiency.
What are the most commonly searched types of Downstream Process Development Scientist jobs in California? The most popular types of Downstream Process Development Scientist jobs in California are:
What cities in California are hiring for Associate Downstream Process Development Scientist jobs? Cities in California with the most Associate Downstream Process Development Scientist job openings:
Associate Downstream Process Development Scientist jobs near you

Associate Scientist, Downstream Process Development

Epicrispr Biotechnologies

South San Francisco, CA • On-site

$118K - $124K/yr

Other

Posted 10 days ago

Job description

Title: Associate Scientist, Downstream Process Development

Location: South San Francisco, CA

Opportunity:

We are seeking a highly motivated and detail-oriented Associate Scientist to join the Downstream Process Development team focused on adeno-associated virus (AAV) gene therapy therapeutics. This role will support the development, optimization, and scale-up of purification processes for AAV vectors from early research through clinical manufacturing.

Responsibilities:

  • Design, execute, and analyze downstream purification experiments for AAV vectors for process steps including clarification, sterile filtration, tangential flow filtration (TFF), chromatography (affinity, ion exchange, size exclusion, mixed mode), and ultracentrifugation.
  • Perform small-scale studies for development of downstream AAV processes, process optimization, process characterization, and assessment of process robustness.
  • Support process development activities from bench scale through pilot scale and tech transfer to GMP manufacturing.
  • Present data and project updates in team meetings and cross-functional forums.
  • Maintain accurate and timely documentation in electronic lab notebooks and technical reports.
  • Collaborate cross-functionally with upstream process development and analytical development and other functions.
  • Stay current with advancements in AAV purification technologies, regulatory expectations, and industry best practices.

Qualifications:
The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

  • B.S. degree in Biochemical Engineering, Chemical Engineering, Molecular Biology, Biotechnology, Biochemistry, or related discipline with 5+ years of relevant industry experience (or M.S. with 3+ years or Ph.D.)
  • Required experience with AKTA purification
  • Strong working knowledge of chromatography and filtration technologies
  • Hands-on experience with viral vector purification, preferably AAV
  • Experience with analytical techniques for AAV characterization such as Refeyn, qPCR/dPCR/ddPCR, ELISA, alkaline gel, CE-SDS, SEC-HPLC, AUC and other similar analytical assays
  • Familiarity with Design of Experiments (DOE) and JMP are a plus
  • Strong organizational, analytical, and problem-solving skills
  • Excellent written and verbal communication skills

Compensation: The salary range for this position is $118,000 to $124,000 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location. 

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