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Full Time Downstream Process Development Scientist Jobs in Baltimore, MD

Senior Biomanufacturing Engineer

Edgewood, MD · On-site

$102K - $141K/yr

Physical Sciences Research; Platform Lifecycle Support; and Foreign Military Sales. Unified by ... Lead development of project-specific process improvements in the Biochemical DSP space * Mentor ...

Senior Biomanufacturing Engineer

Edgewood, MD · On-site

$102K - $141K/yr

Physical Sciences Research; Platform Lifecycle Support; and Foreign Military Sales. Unified by ... Lead development of project-specific process improvements in the Biochemical DSP space * Mentor ...

This is a full-time position requiring 1880 hours of support per year; and work is performed at a ... Bachelor's degree in Computer Science, Information Systems, Engineering, Business, or Education ...

... scientific disciplines. Role Summary The Research and Development Engineer is responsible for planning and executing product and process development activities to support innovation, product ...

... and scientific disciplines. Position Overview: The Research and Development Engineer is responsible for planning and executing product and process development activities to support innovation ...

Data Scientist

Fort George G Meade, MD · On-site

$156K - $176K/yr

Early data science input during IOC ensures that data collected will be suitable for downstream AI development, reducing risk and accelerating capability maturation during follow-on implementation

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Full Time Downstream Process Development Scientist information

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How much do full time downstream process development scientist jobs pay per hour?

As of Aug 8, 2026, the average hourly pay for full time downstream process development scientist in Baltimore, MD is $38.42, according to ZipRecruiter salary data. Most workers in this role earn between $28.17 and $45.87 per hour, depending on experience, location, and employer.

What does a full time downstream process development scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

What are some typical challenges faced by a full time downstream process development scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What are the key skills and qualifications needed to thrive as a full time downstream process development scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.
What are the most commonly searched types of Downstream Process Development Scientist jobs in Baltimore, MD? The most popular types of Downstream Process Development Scientist jobs in Baltimore, MD are:
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What cities near Baltimore, MD are hiring for Full Time Downstream Process Development Scientist jobs? Cities near Baltimore, MD with the most Full Time Downstream Process Development Scientist job openings:
Infographic showing various Full Time Downstream Process Development Scientist job openings in Baltimore, MD as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $79,908 per year, or $38.4 per hour.

Senior Downstream Bioprocess Engineer

Johns Hopkins Applied Physics Laboratory

Laurel, MD • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 5 days ago


Johns Hopkins Applied Physics Laboratory rating

9.6

Company rating: 9.6 out of 10

Based on 8 frontline employees who took The Breakroom Quiz

2nd of 73 rated research


Job description

Description
Do you enjoy developing downstream purification processes for microbial production of small molecules and metabolites?
Do you want to apply your expertise in in downstream bioprocess engineering to pressing national security challenges?
Do you enjoy working as part of an interdisciplinary team of scientists to solve complex biotechnology challenges?
If so, we're looking for someone like you to join our team in the Biological Sciences Group, here at the Johns Hopkins University Applied Physics Lab.
We are seeking a downstream bioprocess engineer to help us develop scalable purification processes for microbial biomanufacturing. You'll join an interdisciplinary team of microbiologists, metabolic engineers, and chemists working together to develop innovative biotechnology solutions for national security. As the team's downstream processing expert, you'll work closely with colleagues across multiple disciplines to recover, purify, and characterize microbially produced small molecules and metabolites.
As part of the Biological Sciences Group, in the Research Exploratory Development Department, you will be at the forefront of APL's mission to provide impactful contributions to critical challenges. You will contribute to building outstanding expertise in molecular biology, in the pursuit of challenges in national security.
As a Senior Downstream Bioprocess Engineer you will...
  • Develop and optimize downstream processes for recovery and purification of microbially produced small molecules and metabolites.
  • Design and execute experiments to improve process performance and characterize biomanufacturing products using analytical chemistry techniques.
  • Collaborate with interdisciplinary teams of scientists and engineers to develop innovative biotechnology solutions for national security applications.
  • Lead technical efforts on internally and externally funded research projects, including project planning, execution, and communication of results.
  • Contribute to the growth of our research portfolio by developing new technical concepts, writing proposals, and building relationships with sponsors and collaborators.

Qualifications
You meet our minimum qualifications for the job if you...
  • Have a PhD in Chemical Engineering, Biological Engineering, Biochemistry, Chemistry, or a related field
  • 1+ year of postdoctoral research experience.
  • Have experience developing downstream processing methods for microbial production of small molecules or metabolites.
  • Have experience developing and applying analytical chemistry methods, including HPLC, LC/MS, GC/MS, or related techniques.
  • Have experience designing, executing, and troubleshooting laboratory experiments for purification, characterization, and process optimization.
  • Have strong written and verbal communication skills, demonstrated through publications, presentations, or related experience.
  • Are able to obtain an Interim Secret level security clearance by your start date and can ultimately obtain a TS/SCI level clearance. If selected, you will be subject to a government security clearance investigation and must meet the requirements for access to classified information. Eligibility requirements include U.S. citizenship.

You'll go above and beyond our minimum requirements if you...
  • Have experience engineering microbial metabolic pathways or microbial strain development.
  • Have experience with yeast or non-model microorganisms.
  • Have experience scaling microbial bioprocesses from bench to pilot scale.
  • Have experience with molecular biology techniques used to support bioprocess development
  • Have experience leading multidisciplinary research projects or developing research proposals.

About Us
Why Work at APL?
The Johns Hopkins University Applied Physics Laboratory (APL) brings world-class expertise to our nation's most critical defense, security, space and science challenges. While we are dedicated to solving complex challenges and pioneering new technologies, what makes us truly outstanding is our culture. We offer a vibrant, welcoming atmosphere where you can bring your authentic self to work, continue to grow, and build strong connections with inspiring teammates.
At APL, we celebrate our differences of perspectives and encourage creativity and bold, new ideas. Our employees enjoy generous benefits, including a robust education assistance program, unparalleled retirement contributions, and a healthy work/life balance. APL's campus is located in the Baltimore-Washington metro area. Learn more about our career opportunities at https://www.jhuapl.edu/careers.
All qualified applicants will receive consideration for employment without regard to race, creed, color, religion, sex, gender identity or expression, sexual orientation, national origin, age, physical or mental disability, genetic information, veteran status, occupation, marital or familial status, political opinion, personal appearance, or any other characteristic protected by applicable law. APL is committed to providing reasonable accommodation to individuals of all abilities, including those with disabilities. If you require a reasonable accommodation to participate in any part of the hiring process, please contact Accessibility@jhuapl.edu.
The referenced pay range is based on JHU APL's good faith belief at the time of posting. Actual compensation may vary based on factors such as geographic location, work experience, market conditions, education/training and skill level with consideration for internal parity. For salaried employees scheduled to work less than 40 hours per week, annual salary will be prorated based on the number of hours worked. APL may offer bonuses or other forms of compensation per internal policy and/or contractual designation. Additional compensation may be provided in the form of a sign-on bonus, relocation benefits, locality allowance or discretionary payments for exceptional performance. APL provides eligible staff with a comprehensive benefits package including retirement plans, paid time off, medical, dental, vision, life insurance, short-term disability, long-term disability, flexible spending accounts, education assistance, and training and development. Applications are accepted on a rolling basis.
Minimum Rate
$105,000 Annually
Maximum Rate
$290,000 Annually

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