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Full Time Downstream Process Development Scientist Jobs

Legend Biotech USA, Inc.

The successful candidate will drive scientific excellence in scaling automation capabilities from ... These benefits are offered exclusively to permanent full-time employees. Contractors are not ...

Kinetic Personnel Group

Downstream Process

Tustin, CA · On-site

Irvine, CA (Onsite) Employment Type: Full-Time Schedule: Mondayâ€"Friday | Standard Business ... This role will partner with Manufacturing, Process Development, Quality, and MSAT teams to analyze ...

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Full Time Downstream Process Development Scientist information

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How much do full time downstream process development scientist jobs pay per hour?

As of Sep 10, 2026, the average hourly pay for full time downstream process development scientist in the United States is $38.66, according to ZipRecruiter salary data. Most workers in this role earn between $28.37 and $46.15 per hour, depending on experience, location, and employer.

What does a full time downstream process development scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What are the key skills and qualifications needed to thrive as a full time downstream process development scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.

What are some typical challenges faced by a full time downstream process development scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

How much does a full time downstream process development scientist make?

In California, a full-time downstream process development scientist typically earns between $80,000 and $130,000 annually, depending on experience, education, and the specific employer. Salaries may also include benefits such as health insurance and bonuses, with higher compensation often associated with advanced skills in bioprocessing and laboratory techniques.

What is a full time downstream process development scientist?

A full-time downstream process development scientist specializes in designing, optimizing, and scaling the purification processes used in biopharmaceutical manufacturing, such as chromatography and filtration. They work to improve product yield, purity, and efficiency, often using laboratory techniques and process modeling tools, typically within a regulated environment requiring compliance with industry standards.
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Full Time Downstream Process Development Scientist jobs near you
Infographic showing various Full Time Downstream Process Development Scientist job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 82% Full Time, 14% Part Time, and 2% Contract. Highlights an 87% Physical, 2% Hybrid, and 11% Remote job distribution, with an average salary of $80,420 per year, or $38.7 per hour.

Sr. Research Associate, Process Development Downstream

Tustin, CA • On-site

Avid Bioservices
Pharmaceutical and Medicine Manufacturing • 51 - 200 employees
Learn more about Avid Bioservicesexternal

$72K - $91K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 19 days ago

Job description

Description
Looking to join a passionate team dedicated to developing and manufacturing life-saving biopharmaceuticals? Avid Bioservices is a leading clinical and commercial biologics CDMO focused on creating innovative solutions to meet the needs of our clients and improve patient outcomes.
Your Role:
The Senior Research Associate, Process Development Downstream will provide laboratory support for Process Development by leading in the downstream process and/or method development. The Senior Research Associate may be assigned various tasks within the department and outside the department as needed.
Key Responsibilities:
  • Serve as a subject matter expert (SME) and/or technical lead for downstream process development and purification of monoclonal antibodies, recombinant proteins, and related biologics. Responsibilities include buffer formulation and preparation, chromatography process development and optimization, filtration development, and routine process execution.
  • Lead downstream process development studies, including chromatography screening, process optimization, and scale-up activities to support client programs from early development through commercialization.
  • Perform and oversee in-process and routine analytical testing to support downstream development activities, including protein concentration determination (A280), HPLC-based assays, and other relevant analytical methods.
  • Independently execute downstream unit operations using chromatography systems, filtration equipment, and associated process analytical tools with minimal supervision.
  • Support process scale-up, technology transfer, and manufacturing operations by developing robust buffer preparation strategies and downstream processing workflows suitable for pilot and GMP manufacturing environments.
  • Compile, analyze, interpret, and present experimental data. Author technical reports, development summaries, protocols, and client-facing documentation, and present findings during internal project reviews and client meetings.
  • Lead troubleshooting and continuous improvement initiatives to enhance process performance, robustness, productivity, and scalability.
  • Contribute to the evaluation, implementation, and validation of emerging technologies, process analytics, laboratory automation platforms, and process intensification strategies to improve development efficiency.
  • Experience with laboratory automation, process intensification, process analytical technologies (PAT), high-throughput process development, and data analytics is highly desirable.
  • Mentor junior scientists and provide technical guidance across downstream process development activities.
  • Perform other duties and project-related responsibilities as assigned.

Minimum Qualifications:
  • Bachelor's degree with 3-4 years of relevant biopharmaceutical industry experience, or a Master's degree in Chemical Engineering, Biochemical Engineering, Biotechnology, Biological Sciences, or a related field.
  • Candidates should possess a strong understanding of downstream processing principles, experimental design, data analysis, and bioprocess development methodologies.

Position Type/Expected Hours of Work:
This role is a full-time onsite position. Days and hours of work are Monday through Friday unless otherwise stated by Supervisor. The employee must also have the ability to work overtime and/or weekends when necessary.
Compensation:
We offer competitive compensation packages for this role, including a base salary, performance-based bonuses, and comprehensive benefits such as health, dental, and vision insurance, 401(k) matching, and paid time off.
The compensation range for this role is $72,800 - $91,000 annually depending on experience and qualifications. Additionally, we offer opportunities for career growth and development as well as a supportive and inclusive work environment.
Who you are:
  • You have a "bring it on!" team player approach and an unshakable positive attitude, always ready to tackle anything that comes your way.
  • Your written and verbal skills are out of this world, and you communicate with clarity and confidence.
  • You have exceptional multitasking skills and an unparalleled attention to detail that ensure the smooth running of everything.
  • You are a master at building relationships, capable of establishing connections with anyone, be it team members, clients, vendors, or suppliers.

Physical Demands & Work Environment:
In this dynamic role, expect a blend of regular activities like sitting, standing, and walking, with occasional physically engaging tasks such as lifting objects up to 25 pounds. The work environment might expose you to electrical shocks, toxic chemicals, vibrations, or loud noise levels occasionally. However, reasonable accommodations are available to enable individuals with different abilities to perform effectively, ensuring a supportive and adaptable work setting. Your visual acuity, including close, distance, and color vision, will be essential in navigating through the diverse day-to-day demands of this position.

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