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Downstream Processing Scientist Jobs (NOW HIRING)

Legend Biotech USA, Inc.

The successful candidate will drive scientific excellence in downstream processing (DSP)-including clarification, chromatography, TFF, sterile filtration and fill/finish-ensuring processes are robust ...

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Downstream Processing Scientist information

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$58.5K

$87.8K

$123.5K

How much do downstream processing scientist jobs pay per year?

As of Jul 24, 2026, the average yearly pay for downstream processing scientist in the United States is $87,842.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,500.00 and $100,000.00 per year, depending on experience, location, and employer.

What are the typical daily responsibilities of a Downstream Processing Scientist?

A Downstream Processing Scientist typically focuses on developing, optimizing, and scaling up purification processes for biologics or pharmaceuticals. Daily tasks include designing and executing experiments, analyzing product purity, maintaining detailed documentation, and troubleshooting process or equipment issues. Collaboration with upstream processing teams, quality assurance, and manufacturing staff is common to ensure seamless product handoff and process improvements. This hands-on, problem-solving work often involves both laboratory-based activities and data analysis, providing a dynamic and engaging work environment.

What are the key skills and qualifications needed to thrive in the Downstream Processing Scientist position, and why are they important?

To thrive as a Downstream Processing Scientist, you need a strong background in biochemistry, chemical engineering, or a related field, along with hands-on experience in purification techniques such as chromatography and filtration. Familiarity with laboratory automation systems, analytical instrumentation (e.g., HPLC, SDS-PAGE), and regulatory standards like GMP is essential. Strong problem-solving abilities, teamwork, and clear scientific communication set top performers apart in this role. These skills ensure efficient purification of bioproducts, regulatory compliance, and successful collaboration within multidisciplinary teams.

What is a Downstream Processing Scientist job?

A Downstream Processing Scientist is responsible for the purification and recovery of biological products, such as proteins, antibodies, or vaccines, after fermentation or cell culture. They develop and optimize processes like chromatography, filtration, and centrifugation to ensure product quality and yield. Their role also includes scaling up purification methods, troubleshooting process challenges, and working within regulatory guidelines. They often collaborate with upstream processing teams, analytical scientists, and quality control departments to ensure smooth production.

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What cities are hiring for Downstream Processing Scientist jobs? Cities with the most Downstream Processing Scientist job openings:
What are the most commonly searched types of Downstream Processing Scientist jobs? The most popular types of Downstream Processing Scientist jobs are:
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Downstream Processing Scientist jobs near you
Infographic showing various Downstream Processing Scientist job openings in the United States as of July 2026, with employment types broken down into 98% Full Time, and 2% Temporary. Highlights an 96% In-person, 2% Hybrid, and 2% Remote job distribution, with an average salary of $87,842 per year, or $42.2 per hour.
Downstream Processing Operator

Downstream Processing Operator

Danimer Scientific

Winchester, KY • On-site

$16.50 - $20.75/hr

Full-time

Medical, Dental, Vision, Retirement

Posted 26 days ago

Job description

Benefits:
  • 401(k)
  • 401(k) matching
  • Bonus based on performance
  • Dental insurance
  • Health insurance
  • Training & development
  • Vision insurance
  • Wellness resources

NOW INTERVIEWING FOR FUTURE OPPORTUNITIES:
Downstream Processing (DSP) Operator
Winchester, KY | Biodegradable Plastics
Schedule: 12 Hour Shifts on a 2-2-3 pattern (Day or Night Availability Required)
Employment Type: Non-exempt | Full-time
At Danimer Scientific, we're building the future of sustainable materials-and that takes skilled operators who care about quality, safety, and doing things the right way. As a Downstream Processing (DSP) Operator, you'll play a hands-on role in producing advanced materials in a cGMP manufacturing environment while working with a collaborative, safety-focused team.
If you enjoy technical work, problem-solving, and being part of a process that truly matters, we'd love to meet you.
What You'll Do
Under the guidance of a Team Leader and Manufacturing Management, the DSP Operator is responsible for executing day-to-day production activities in the Downstream Processing area. This role is hands-on, detail-oriented, and critical to maintaining product quality and process reliability.
Key Responsibilities Include:
  • Operate and monitor downstream processing equipment and utilities
  • Start/stop pumps, open/close manual valves, collect samples, and respond to process alarms
  • Monitor process conditions and adjust parameters to maintain stability
  • Accurately complete batch records, logbooks, and production documentation in compliance with cGMP standards
  • Review production documentation for accuracy, completeness, and quality compliance
  • Add chemicals and process additives based on calculations and procedures
  • Troubleshoot process or equipment deviations and initiate corrective actions
  • Communicate production metrics, issues, and shift handoffs clearly
  • Maintain clean, organized, and audit-ready work areas per GMP standards
  • Participate in continuous improvement initiatives related to safety, quality, and efficiency
  • Train and support new or developing operators
  • Serve as a safety leader-stop production when a quality or safety concern is identified

What We're Looking For
Required Qualifications
  • High school diploma or GED
  • Minimum of 2 years of experience in a manufacturing or industrial environment
  • Ability to work independently and as part of a team
  • Strong attention to detail and commitment to documentation accuracy
  • Mechanically inclined with strong problem-solving skills
  • Comfortable working with automated systems and manual equipment
  • Proficient with basic computer systems (Microsoft Suite)

Preferred Qualifications
  • Associate degree in applied process technologies or related field
  • Prior experience in biotech, chemical, or cGMP manufacturing
  • Working knowledge of GMP, safety protocols, and quality systems

Work Schedule
  • Full-time, 12-hour shifts
  • Days or nights, including weekends, holidays, and overtime as required

Physical & Work Environment Requirements
  • Ability to stand, walk, bend, stoop, and perform repetitive tasks for extended periods
  • Ability to lift up to 50 lbs occasionally and climb ladders/stairs
  • Work in hot, cold, loud, and industrial manufacturing environments
  • Use of PPE including hearing protection in designated areas
  • Exposure to moving mechanical parts, vibration, fumes, and airborne particles

Why Danimer?
Mission-driven work (bye, plastic pollution)
Growth opportunity
Great pay + benefits
Team-first culture
Equal Opportunity Employer
Danimer Scientific provides equal employment opportunities to all employees and applicants without regard to race, color, religion, sex, national origin, age, disability, genetics, or any other status protected by law. We comply with all federal, state, and local laws governing nondiscrimination in every location where we operate.
We strictly prohibit any form of workplace harassment or discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, veteran status, or any other protected status.
Apply now and be part of something bigger
We're advancing the future of sustainable materials - and we're not alone!
Our commitment to replacing traditional plastics with biodegradable, compostable solutions is now backed by a strong, new partnership with - a global leader in material science. Together, we're turning shared vision and shared values into real-world impact.
Join us as we celebrate a partnership that moves sustainability forward!

Apply