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Downstream Processing Scientist Jobs (NOW HIRING)

Lonza

Scientist II, Downstream

Houston, TX · On-site

Scientist II, Downstream Location: This is an on-site position located in Pearland, TX. The purpose ... The ideal candidate will be responsible for leading new process development and improving existing ...

Kinetic Personnel Group

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Supervisor, Manufacturing - Downstream

Irvine, CA · On-site

$75K - $95K/yr

Perform hands-on purification processes, including column chromatography, tangential flow ... Bachelor's degree in life sciences or a closely related discipline * Demonstrated leadership in ...

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CEDENT

Senior Scientist, Process Development

Watertown, MA

$99K - $135K/yr

... downstream processing, analyzing data, and contributing to process development projects. The ideal candidate will be involved in troubleshooting complex issues. The position requires a strong ...

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How much do downstream processing scientist jobs pay per year?

As of Jul 3, 2026, the average yearly pay for downstream processing scientist in the United States is $87,842.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,500.00 and $100,000.00 per year, depending on experience, location, and employer.

What are the typical daily responsibilities of a Downstream Processing Scientist?

A Downstream Processing Scientist typically focuses on developing, optimizing, and scaling up purification processes for biologics or pharmaceuticals. Daily tasks include designing and executing experiments, analyzing product purity, maintaining detailed documentation, and troubleshooting process or equipment issues. Collaboration with upstream processing teams, quality assurance, and manufacturing staff is common to ensure seamless product handoff and process improvements. This hands-on, problem-solving work often involves both laboratory-based activities and data analysis, providing a dynamic and engaging work environment.

What are the key skills and qualifications needed to thrive in the Downstream Processing Scientist position, and why are they important?

To thrive as a Downstream Processing Scientist, you need a strong background in biochemistry, chemical engineering, or a related field, along with hands-on experience in purification techniques such as chromatography and filtration. Familiarity with laboratory automation systems, analytical instrumentation (e.g., HPLC, SDS-PAGE), and regulatory standards like GMP is essential. Strong problem-solving abilities, teamwork, and clear scientific communication set top performers apart in this role. These skills ensure efficient purification of bioproducts, regulatory compliance, and successful collaboration within multidisciplinary teams.

What is a Downstream Processing Scientist job?

A Downstream Processing Scientist is responsible for the purification and recovery of biological products, such as proteins, antibodies, or vaccines, after fermentation or cell culture. They develop and optimize processes like chromatography, filtration, and centrifugation to ensure product quality and yield. Their role also includes scaling up purification methods, troubleshooting process challenges, and working within regulatory guidelines. They often collaborate with upstream processing teams, analytical scientists, and quality control departments to ensure smooth production.

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Downstream Processing Scientist jobs near you
Scientist II, Downstream

Scientist II, Downstream

Lonza

Houston, TX • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 29 days ago

Lonza rating

8.2

Company rating: 8.2 out of 10

Based on 41 frontline employees who took The Breakroom Quiz

29th of 73 rated pharmaceutical

Job description

Scientist II, Downstream
Location: This is an on-site position located in Pearland, TX.
The purpose of this role is to work in a high performing, cross functional team with the goal of driving innovation in the development of scalable downstream processes related to the manufacture of therapeutic gene therapy products. The ideal candidate will be responsible for leading new process development and improving existing processes. The incumbent will independently design and coordinate the execution of experiments related to the purification of viral based gene therapy products, and be an excellent communicator.
What you will get:
A competitive compensation. In addition, below you will find a comprehensive summary of the benefits package we offer:
  • Performance-related bonus.
  • Medical, dental and vision insurance.
  • 401(k) matching plan.
  • Life insurance, as well as short-term and long-term disability insurance.
  • Employee assistance programs.
  • Paid time off (PTO).

Compensation for this role will be determined by the candidate's qualifications, skills, experience, and relevant knowledge.
What you will do:
  • Interacts with clients regarding process development scopes and tech transfer activities as well as data discussion and challenge resolutions.
  • Responsible for tech transfer to manufacturing following Lonza guidelines, provides ongoing supports as needed.
  • Designs and executes experiments, analyzes data. Authoring study protocols and reports. Maintains accurate & detailed records following Lonza's best documentation practices.
  • Contributes and supports scientific and engineering expertise toward the design and development of new downstream process ideas that support client product concepts.
  • Establish collaborative relationships and serve as SME to cross-functional groups (MSAT, MFG, QC, and PM).
  • Mentor and train junior colleagues.

What we are looking for:
  • PhD or MS in Life Sciences with focus on biology or bioengineering
  • Experience with development and optimization of viral or protein purification process including chromatography, filtration and formulation unit operations.
  • Experience with the technology transferring of viral or protein related downstream processes to cGMP manufacturing.
  • Experience or knowledge of analytical methods and in process controls commonly used in manufacturing processes.
  • Experience with late-stage process development for viral or protein related downstream process is highly desirable.

About Lonza:
At Lonza, our people are our greatest strength. With 30+ sites across five continents, our globally connected teams work together every day to manufacture the medicines of tomorrow. Our core values of Collaboration, Accountability, Excellence, Passion and Integrity reflect who we are and how we work together. Everyone's ideas, big or small, have the potential to improve millions of lives, and that's the kind of work we want you to be part of.
Innovation thrives when people from all backgrounds bring their unique perspectives to the table. At Lonza, we offer equal employment opportunities to all qualified applicants regardless of race, religion, color, national origin, sex, sexual orientation, gender identity, age, disability, veteran status, or any other characteristic protected by law. If you're ready to help turn our customers' breakthrough ideas into viable therapies, we look forward to welcoming you on board.
Ready to shape the future of life sciences? Apply now.

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