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Senior Scientist, Process Development

Watertown, MA

$99K - $135K/yr

... downstream processing, analyzing data, and contributing to process development projects. The ideal candidate will be involved in troubleshooting complex issues. The position requires a strong ...

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How much do downstream processing scientist jobs pay per year?

As of Jun 7, 2026, the average yearly pay for downstream processing scientist in the United States is $87,842.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,500.00 and $100,000.00 per year, depending on experience, location, and employer.

What are the typical daily responsibilities of a Downstream Processing Scientist?

A Downstream Processing Scientist typically focuses on developing, optimizing, and scaling up purification processes for biologics or pharmaceuticals. Daily tasks include designing and executing experiments, analyzing product purity, maintaining detailed documentation, and troubleshooting process or equipment issues. Collaboration with upstream processing teams, quality assurance, and manufacturing staff is common to ensure seamless product handoff and process improvements. This hands-on, problem-solving work often involves both laboratory-based activities and data analysis, providing a dynamic and engaging work environment.

What are the key skills and qualifications needed to thrive in the Downstream Processing Scientist position, and why are they important?

To thrive as a Downstream Processing Scientist, you need a strong background in biochemistry, chemical engineering, or a related field, along with hands-on experience in purification techniques such as chromatography and filtration. Familiarity with laboratory automation systems, analytical instrumentation (e.g., HPLC, SDS-PAGE), and regulatory standards like GMP is essential. Strong problem-solving abilities, teamwork, and clear scientific communication set top performers apart in this role. These skills ensure efficient purification of bioproducts, regulatory compliance, and successful collaboration within multidisciplinary teams.

What is a Downstream Processing Scientist job?

A Downstream Processing Scientist is responsible for the purification and recovery of biological products, such as proteins, antibodies, or vaccines, after fermentation or cell culture. They develop and optimize processes like chromatography, filtration, and centrifugation to ensure product quality and yield. Their role also includes scaling up purification methods, troubleshooting process challenges, and working within regulatory guidelines. They often collaborate with upstream processing teams, analytical scientists, and quality control departments to ensure smooth production.

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What cities are hiring for Downstream Processing Scientist jobs? Cities with the most Downstream Processing Scientist job openings:
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Downstream Processing Scientist jobs near you
Infographic showing various Downstream Processing Scientist job openings in the United States as of May 2026, with employment types broken down into 100% Full Time. Highlights an 80% In-person, and 20% Remote job distribution, with an average salary of $87,842 per year, or $42.2 per hour.

(Sr) Technician, Downstream Process

GenScript/ProBio

Hopewell, NJ • On-site

$60K - $75K/yr

Full-time

Posted 26 days ago

Job description

About GenScriptGenScript Biotech Corporation (Stock Code: 1548.HK) is a global biotechnology group. Founded in 2002, GenScript has an established global presence across North America, Europe, the Greater China, and Asia Pacific. GenScript's businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy.GenScript is committed to striving towards its vision of being the most reliable biotech company in the world to make humans and nature healthier through biotechnology.

About ProBio:

ProBio, a subsidiary of GenScript, is a global CDMO offering end-to-end services from discovery to GMP for plasmids, antibodies, and cell & gene therapies. We bring together multidisciplinary expertise to accelerate development and manufacturing through customized, and comprehensive services. ProBio has established companies in the United States, the Netherlands, South Korea, and China (Hong Kong, Shanghai, and Nanjing) and other regions to serve global customers, and has helped customers in the United States, Europe, Asia Pacific and other regions obtain more than 150 IND approvals since October 2017.

About the job:

The (Sr) Technician, Downstream Process will work within the Downstream Processing group and performs the following activities while executing Downstream operations:

  • Preparation of stock solutions, and buffers.
  • Filtration of stock solutions and buffers.
  • Operates all production equipment in assigned functional area such as single use chromatography systems, chromatography columns, other disposable Bioprocess equipment, and solution preparation equipment as per written procedures.
  • The (Sr) Technician, Downstream Process supports relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.

Location: Pennington, NJ

Responsibilities:

  • Executes routine complex manufacturing assignments per written procedures; recognizes deviations from procedures and raises issue to management for resolution.
  • Adheres to current Good Manufacturing Practices (cGMP) and Standard Operating Procedures (SOPs).
  • Performs routine microbial and mammalian purification. Monitors chromatography and tangential flow filtration (TFF) systems during processing.
  • Weighs and checks raw materials, assembles process equipment, and monitors processes.
  • Completes work instructions and maintains clean room environment to comply with regulatory requirements
  • Operates all production equipment in assigned functional area such as single use chromatography systems, chromatography columns, other disposable Bioprocess equipment, and solution preparation equipment as per written procedures.
  • Authors solution preparation Master Batch Records (MBRs) by transferring technical information from scientific and development documents.
  • Proposes and routes revisions to existing SOP's for functional area equipment.
  • Works to become proficient on common bioprocessing equipment.
  • Conducts Safety and GMP self-auditing walkthroughs, documenting observations for assignment and closure dates. Tracks and ensures closure of observations.
  • Logs and submits samples in Laboratory Information Management System (LIMS); tracks results and compiles data.
  • Reviews own work for completeness on executed Master Batch Records (MBRs).
  • Coordinate the tracking and return of executed records to Quality department for review.
  • Coordinates with Logistics to ensure needed materials are delivered to the production area timely. Monitors future needs against material supply to alert Logistics of shortfalls.
  • Performs other tasks and assignments as needed and specified by management.

Qualifications:

  • Bachelor's degree in science or engineering with a 0 – 5 years relevant experience or an Associate's degree in science or engineering with a minimum of 3 years relevant experience or a High school diploma with a minimum of 7 years relevant experience.
  • Demonstrated ability to follow written instructions and procedures.
  • Demonstrated ability to pay strict attention to detail.
  • Proficiency with Microsoft Office.
  • Excellent verbal and written communication and skills.
  • Ability to work collaboratively as part of a team, in a fast-paced, matrixed, team environment consisting of internal and external team members.

The estimated pay range for the role is between $60,000 - $75,000 based on qualifications and experience.

#PB

#AH

GenScript USA Inc/ProBio Inc. is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is the Company's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

GenScript USA Inc./ProBio Inc. maintains a drug-free workplace.

Please note: Genscript USA Inc./ProBio Inc. will only contact candidates through verified application sources. GenScript/Probio does not request personal information from candidates through individual email or any other platform.