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Intern Downstream Processing Scientist Jobs (NOW HIRING)

Legend Biotech USA, Inc.

The successful candidate will drive scientific excellence in downstream processing (DSP)-including clarification, chromatography, TFF, sterile filtration and fill/finish-ensuring processes are robust ...

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What is the difference between Intern Downstream Processing Scientist vs Intern Upstream Processing Scientist?

AspectIntern Downstream Processing ScientistIntern Upstream Processing Scientist
CredentialsTypically pursuing or holding a degree in Biotechnology, Biochemistry, or related fieldsSame as downstream role, often with focus on bioprocessing or molecular biology
Work EnvironmentLaboratories, manufacturing facilities, quality control labsLaboratories, bioreactors, research and development settings
Industry UsagePharmaceutical, biotech, and bioprocessing companiesSame industries, focusing on different stages of bioprocessing

Both roles involve working in biotech and pharmaceutical settings, with similar educational backgrounds. The main difference is the focus: downstream processing scientists handle purification and formulation, while upstream processing scientists focus on cell culture and bioreactor operations. Interns in both roles gain hands-on experience in bioprocessing, but their specific tasks differ according to the stage of production.

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Infographic showing various Intern Downstream Processing Scientist job openings in the United States as of May 2026, with employment types broken down into 98% Full Time, 1% Temporary, and 1% Nights. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution.

Research Intern (Downstream Processing) - Onsite Marlborough, MA

SARTORIUS AG

Marlborough, MA

$30/hr

Other

Posted 16 days ago

Job description

We are seeking a motivated and technically skilled intern (PhD level) to support research and development activities in downstream processing of extracellular vesicles (EVs) and viral vectors. The successful candidate will work closely with a multidisciplinary team to optimize and execute purification workflows using tangential flow filtration (TFF) and chromatography-based methods. This internship provides hands-on experience in biologics processing and analytical evaluation, contributing directly to process development for therapeutic nanoparticles.
Onsite at our Marlborough, MA site,
In the Research Intern role, you will serve as a critical contributor to the development and integration of Sartorius' emerging technologies for characterization and purification of different types of nanoparticles such as extracellular vesicles and viral vectors. These leading-edge platforms will be utilized in basic research as well as the pharmaceutical and biotechnology industries.
What you will accomplish together with us

  • Execute Purification Protocols: Perform purification of EVs and viral vectors using TFF systems (hollow fiber and/or flat sheet) and various chromatography modalities (e.g., ion exchange, size exclusion, affinity).
    Optimize Unit Operations: Assist in the design and optimization of downstream steps to improve product yield, purity, and scalability.
    System Operation and Maintenance: Operate and maintain TFF and chromatography systems (e.g., AKTA or equivalent), including set-up, cleaning, and troubleshooting.
    Sample Handling and Quantification: Prepare and process samples following SOPs. Quantify particles using orthogonal methods such as NTA, qPCR, protein assays, and total RNA analysis.
    Process Monitoring and Data Recording: Monitor and document key parameters (e.g., transmembrane pressure, flux, recovery) during TFF runs. Maintain detailed lab notebooks and process logs.
    Analytical Support: Support integration of downstream data with analytical assays (e.g., flow cytometry, SEC-MALS, SDS-PAGE) for process characterization.
    Collaborative Work: Interact regularly with upstream, analytical, and formulation teams to align on process goals and transfer knowledge.
    Safety and Compliance: Follow laboratory safety protocols and ensure compliance with quality standards and experimental reproducibility.
What will convince us
Education:
  • PhD candidate in Bioengineering, or closely related discipline with formal education and experience with extracellular vesicles characterization and purification.
Experience:
  • Hands-on experience with TFF systems (lab or pilot scale) for nanoparticle or biologics concentration and diafiltration.
    Practical knowledge of chromatography techniques such as SEC, IEX, or affinity purification.
    Familiarity with nanoparticle systems such as EVs, viral vectors (e.g., AAV, lentivirus), or LNPs.
    Comfortable working in a wet lab environment with complex biological samples.
    Strong documentation and organizational skills; experience with SOPs and batch records is a plus.
    Experience with analytical tools (e.g., NTA, BCA, qPCR, HPLC, or SEC-MALS) is highly desirable
  • Identification with our core values: Sustainability, Openness, Enjoyment

Compensation is up to $30 hr.
What We Offer
As a growing global life science company, with our stock listed on the German DAX and TecDAX , Sartorius offers a wide range of benefits:
Personal and Professional Development: Mentoring, leadership programs, internal seminar offerings
Making an Impact Right from the Start: Comprehensive onboarding, including a virtual online platform
Welcoming Culture: Mutual support, team spirit and international collaboration; communities on numerous topics such as "Coaching", "Agile Working" and a "Businesswomen's Network"
Intelligent Working Environment: Working in smart buildings with the latest technology and equipment.
Sartorius is an equal opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, national origin, age, protected veteran status, disability or based on status in any other protected group of class.
Please view equal employment opportunity posters provided by OFCCP here.
E-Verify Participation Info
E-Verify Workers Rights
Sartorius is part of the solution in the fight against cancer, dementia, and many other diseases. Our technologies help translate scientific discoveries into real-world medicine faster, so that new therapeutics can reach patients worldwide. We look for ambitious team players and creative minds, who want to contribute to this goal and advance their careers in a dynamic global environment. Join our global team and become part of the solution. We are looking forward to receiving your application.
We look forward to receiving your application.
www.sartorius.com/career
If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening. You can request reasonable accommodation by e-mail at accommodationrequest@sartorius.com
Sartorius is an equal opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, national origin, age, protected veteran status, or disability, or based on status in any other protected group of class.
If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening. You can request reasonable accommodation by e-mail at accommodationrequest@sartorius.com
About Sartorius
Sartorius is part of the solution in the fight against cancer, dementia, and many other diseases. Our technologies help translate scientific discoveries into real-world medicine faster, so that new therapeutics can reach patients worldwide.
We look for ambitious team players and creative minds, who want to contribute to this goal and advance their careers in a dynamic global environment.
Join our global team and become part of the solution. We are looking forward to receiving your application.
www.sartorius.com/careers

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