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Intern Downstream Processing Scientist Jobs (NOW HIRING)

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Senior Scientist, Process Development

Watertown, MA

$99K - $135K/yr

... downstream processing, analyzing data, and contributing to process development projects. The ideal candidate will be involved in troubleshooting complex issues. The position requires a strong ...

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What is the difference between Intern Downstream Processing Scientist vs Intern Upstream Processing Scientist?

AspectIntern Downstream Processing ScientistIntern Upstream Processing Scientist
CredentialsTypically pursuing or holding a degree in Biotechnology, Biochemistry, or related fieldsSame as downstream role, often with focus on bioprocessing or molecular biology
Work EnvironmentLaboratories, manufacturing facilities, quality control labsLaboratories, bioreactors, research and development settings
Industry UsagePharmaceutical, biotech, and bioprocessing companiesSame industries, focusing on different stages of bioprocessing

Both roles involve working in biotech and pharmaceutical settings, with similar educational backgrounds. The main difference is the focus: downstream processing scientists handle purification and formulation, while upstream processing scientists focus on cell culture and bioreactor operations. Interns in both roles gain hands-on experience in bioprocessing, but their specific tasks differ according to the stage of production.

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What are the most commonly searched types of Downstream Processing Scientist jobs? The most popular types of Downstream Processing Scientist jobs are:
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Infographic showing various Intern Downstream Processing Scientist job openings in the United States as of May 2026, with employment types broken down into 98% Full Time, 1% Temporary, and 1% Nights. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution.

Associate Scientist, Downstream Process Development

Epicrispr Biotechnologies

South San Francisco, CA • On-site

$118K - $124K/yr

Full-time

Posted 12 days ago

Job description

Who Are We?
Our company is based on the science of our founder, Stanley Qi, one of the original CRISPR co-inventors who then furthered the technology so that DNA does not need to be cut to accomplish gene regulation. Instead, we regulate the epigenome to suppress and activate multiple genes simultaneously. We are further evolving the platform and leveraging its strengths to address unmet medical needs.
We are looking for exceptional team members who want an active role in building a rapidly growing biotech.
Title: Associate Scientist, Downstream Process Development
Location: South San Francisco, CA
Opportunity:
We are seeking a highly motivated and detail-oriented Associate Scientist to join the Downstream Process Development team focused on adeno-associated virus (AAV) gene therapy therapeutics. This role will support the development, optimization, and scale-up of purification processes for AAV vectors from early research through clinical manufacturing.
Responsibilities:
  • Design, execute, and analyze downstream purification experiments for AAV vectors for process steps including clarification, sterile filtration, tangential flow filtration (TFF), chromatography (affinity, ion exchange, size exclusion, mixed mode), and ultracentrifugation.
  • Perform small-scale studies for development of downstream AAV processes, process optimization, process characterization, and assessment of process robustness.
  • Support process development activities from bench scale through pilot scale and tech transfer to GMP manufacturing.
  • Present data and project updates in team meetings and cross-functional forums.
  • Maintain accurate and timely documentation in electronic lab notebooks and technical reports.
  • Collaborate cross-functionally with upstream process development and analytical development and other functions.
  • Stay current with advancements in AAV purification technologies, regulatory expectations, and industry best practices.

Qualifications:
The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.
  • B.S. degree in Biochemical Engineering, Chemical Engineering, Molecular Biology, Biotechnology, Biochemistry, or related discipline with 5+ years of relevant industry experience (or M.S. with 3+ years or Ph.D.)
  • Required experience with AKTA purification
  • Strong working knowledge of chromatography and filtration technologies
  • Hands-on experience with viral vector purification, preferably AAV
  • Experience with analytical techniques for AAV characterization such as Refeyn, qPCR/dPCR/ddPCR, ELISA, alkaline gel, CE-SDS, SEC-HPLC, AUC and other similar analytical assays
  • Familiarity with Design of Experiments (DOE) and JMP are a plus
  • Strong organizational, analytical, and problem-solving skills
  • Excellent written and verbal communication skills

Compensation: The salary range for this position is $118,000 to $124,000 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.
Epicrispr Biotechnologies is an early-stage biotechnology company developing a novel technology platform that can provide safe and persistent control of targeted gene regulation. Our proprietary platform represents an entirely new class of therapeutics that can be leveraged to treat severe disease across numerous therapeutic areas, including complex diseases impacted by multiple genes.
Epicrispr Biotechnologies provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.
This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

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