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Upstream Process Development Scientist Jobs (NOW HIRING)

Legend Biotech USA, Inc.

Legend Biotech is seeking a Principal Scientist, Lentivirus Upstream Process Development as part of the Technical Development team based in Somerset, NJ.Role OverviewThe Principal Scientist ...

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How much do upstream process development scientist jobs pay per hour?

As of Jun 5, 2026, the average hourly pay for upstream process development scientist in the United States is $38.66, according to ZipRecruiter salary data. Most workers in this role earn between $28.37 and $46.15 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an Upstream Process Development Scientist, and why are they important?

To thrive as an Upstream Process Development Scientist, you need a strong background in bioprocess engineering, cell culture, and molecular biology, typically supported by a degree in life sciences or biochemical engineering. Familiarity with bioreactor systems, analytical instrumentation, and data analysis software, as well as experience with cGMP and regulatory guidelines, is essential. Strong problem-solving abilities, teamwork, and effective communication help drive innovation and collaboration in the lab. These skills are crucial for optimizing cell culture processes, ensuring product quality, and meeting timelines in biopharmaceutical development.

What are some typical challenges faced by Upstream Process Development Scientists, and how are they addressed in the workplace?

Upstream Process Development Scientists often encounter challenges such as optimizing cell culture conditions for maximum yield, scaling up processes from bench to pilot or production scale, and troubleshooting variability in biological systems. These challenges are typically addressed through rigorous experimental design, close collaboration with cross-functional teams like analytical development and quality assurance, and leveraging data-driven approaches to problem-solving. Regular team meetings and access to advanced instrumentation also provide support, ensuring that scientists can quickly adapt to evolving project needs and industry standards.

What does an Upstream Process Development Scientist do?

An Upstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes for the production of biological products such as proteins, vaccines, or antibodies. They primarily focus on cell culture, fermentation, and bioreactor operations to maximize yield and product quality. These scientists work closely with research and manufacturing teams to develop efficient and reproducible processes that can be transferred to large-scale production. Their work is essential in the biotechnology and pharmaceutical industries for the development of new therapeutics.

What is the difference between Upstream Process Development Scientist vs Downstream Process Development Scientist?

AspectUpstream Process Development ScientistDownstream Process Development Scientist
Focus AreaBioreactor cultivation, cell culture optimization, media developmentPurification, filtration, chromatography, product recovery
Skills & CertificationsCell biology, bioprocessing, GMP regulationsProtein chemistry, purification techniques, GMP compliance
Work EnvironmentLaboratories, bioreactors, pilot plantsLaboratories, purification facilities, pilot plants
Industry UsageBiopharmaceuticals, biotech companies, contract manufacturingBiopharmaceuticals, biotech companies, contract manufacturing

Both roles are essential in bioprocessing, with upstream scientists focusing on cell growth and media optimization, while downstream scientists handle product purification. They often collaborate closely within biopharmaceutical manufacturing to ensure efficient production and high-quality biologics.

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Upstream Process Development Scientist jobs near you
Infographic showing various Upstream Process Development Scientist job openings in the United States as of May 2026, with employment types broken down into 82% Full Time, and 18% Part Time. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $80,420 per year, or $38.7 per hour.

Upstream Process Development Scientist (Cell Culture, Bioreactors)

Pioneer Data

Andover, MA • On-site

Contractor

Posted 15 days ago

Job description

Position Details: 
Our client, a world-leading Pharmaceutical Company in Andover, MA is currently looking for a Upstream Process Development Scientist (Cell Culture, Bioreactors) to join their expanding team.
 
Job Title: Upstream Process Development Scientist (Cell Culture, Bioreactors)
Duration: 12 months contract, extendable up to 48 months
Location: Andover, MA
 
Note: 
The client has the right-to-hire you as a permanent employee at any time during or after the end of the contract.
You may participate in the company group medical insurance plan
 
Job Description:
Summary:
Manufacturing Sciences and Technology (MSAT) at client is looking for a highly motivated, versatile candidate to join our multidisciplinary team of scientists and engineers in Andover, MA. 
The group supports Pfizer’s portfolio of late stage development and commercial biopharmaceuticals and vaccines, and is responsible for process troubleshooting, process improvements and second- generation process development. 
We are looking for someone who is eager to contribute independent thinking and technical excellence to the upstream cell culture mammalian team.
The ideal candidate will be a valuable contributor to the upstream team within MSAT Andover. 
The role is well-integrated with the rest of the MSAT group and will involve a lot of collaborative work both within the group and across the Andover site. 
The colleague will be expected to plan and execute well-designed lab experiments in cell culture with pre-defined goals. This includes basic analytics, data acquisition and interpretation, user-level maintenance of the relevant equipment and documentation of work.
 
Job Responsibilities:
Plan and execute upstream mammalian process experiments at laboratory scales.
Operate and maintain laboratory bioreactors and associated analytic tools.
Understand and (as necessary) adjust control and data acquisition systems.
Document results and present them to internal teams.
Assist in manufacturing investigations and process troubleshooting.
 
Qualifications:
Bachelor’s degree in a relevant discipline with 3 years of applicable bioprocess experience.
Proficient in aseptic technique (required).
Experience in laboratory bioreactor operation and associated analytical tools (required).
Familiarity with control and data acquisition systems.
Knowledge of all aspects of cell culture bioreactor operation modes, i.e. batch, fed-batch, continuous.
Experience with processing and interpreting large data sets.
Involves typical bioprocessing lab activities (Examples: Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis).
 
Additional Qualifications:
May require some out of hours working to support laboratory and off hours cell culture work, e.g weekend coverage once a month.