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Full Time Downstream Process Development Scientist Jobs in Raleigh, NC

Valspec

Validation Engineer (CQV)

Holly Springs, NC

... or life sciences manufacturing * Hands-on experience with downstream processing equipment ... Join a team where your contributions matter, your development is prioritized, and your success is ...

New

Valspec

Validation Engineer (CQV)

Raleigh, NC

... or life sciences manufacturing * Hands-on experience with downstream processing equipment ... Join a team where your contributions matter, your development is prioritized, and your success is ...

New

Valspec

Validation Engineer

Raleigh, NC

... or life sciences manufacturing * Hands-on experience with downstream processing equipment ... Join a team where your contributions matter, your development is prioritized, and your success is ...

Valspec

Validation Engineer

Holly Springs, NC

... or life sciences manufacturing * Hands-on experience with downstream processing equipment ... Join a team where your contributions matter, your development is prioritized, and your success is ...

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All JobsDownstream Process Development Scientist JobsFull Time Downstream Process Development Scientist JobsFull Time Downstream Process Development Scientist Jobs in Raleigh, NC

Full Time Downstream Process Development Scientist information

See Raleigh, NC salary details

$20

$37

$59

How much do full time downstream process development scientist jobs pay per hour?

As of Jul 10, 2026, the average hourly pay for full time downstream process development scientist in Raleigh, NC is $37.58, according to ZipRecruiter salary data. Most workers in this role earn between $27.60 and $44.86 per hour, depending on experience, location, and employer.

What does a Full Time Downstream Process Development Scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

What are some typical challenges faced by a Downstream Process Development Scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What are the key skills and qualifications needed to thrive as a Full Time Downstream Process Development Scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.
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Full Time Downstream Process Development Scientist jobs near you
Infographic showing various Full Time Downstream Process Development Scientist job openings in Raleigh, NC as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $78,175 per year, or $37.6 per hour.
Process Development Associate Scientist

Process Development Associate Scientist

DSC Resources

Durham, NC

$90K - $100K/yr

Full-time

Posted 17 days ago

Job description

Process Development & Scale-Up Associate


No visa sponsorship | No third-party agencies


** Must be local to the Durham, NC area **


Seeking a motivated individual with experience in fermentation and downstream processing development and scale-up. This role reports to the Senior Director of Operations and sits within the supply chain and operations team. As the Process Development & Scale-Up Associate, you will support the technical development of new strains and help guide selected programs from bench-scale development to mature manufacturing at scale — sitting at the intersection of science and operations, with end-to-end visibility of product development and the opportunity to contribute directly to technical success across active scale-up programs. Alongside deep technical understanding, you will be expected to consider practical aspects of the business and support the operational excellence of the processes you develop.


Experience:

  • Bachelor's degree or higher in relevant field (life sciences, engineering)
  • 2–5 years of experience in industrial fermentation, biotechnology, or downstream processing
  • Experience with technical transfer documents and scale-up
  • Experience with live probiotic strains preferred
  • Experience with anaerobic strains preferred


Role:

  • Work with CDMOs and CMOs to develop processes for scaling novel strains in the probiotics industry
  • Help guide processes from proof-of-concept at bench scale to pilot and manufacturing scales
  • Conduct thorough research and contribute to the development of processes that meet the company's cost targets for commercialization of new technologies
  • Organize and maintain data records of all process development, both in-house and across partner facilities
  • Track and maintain timelines to ensure projects meet required deadlines
  • Travel to 3rd party facilities to support development and aid in commercialization efforts (25%)
  • Troubleshoot issues related to technology scale-up
  • Assist with various downstream applications including product formulation, stability, and shelf life
  • Contribute to development of downstream applications for freeze drying, spray drying, and cryopreservation


Salary - $90,000