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Full Time Downstream Process Development Scientist Jobs in Raleigh, NC

AskBio

Process Engineer II

Durham, NC · On-site

Pioneering science to create transformative molecular medicines. Our mission: Lead innovative ... Hands-on upstream or downstream biomanufacturing laboratory experience * Excellent written and ...

AskBio

Process Engineer II

Durham, NC · On-site

Pioneering science to create transformative molecular medicines. Our mission: Lead innovative ... Hands-on upstream or downstream biomanufacturing laboratory experience * Excellent written and ...

MedPharm

Sr. Process Engineer/Sr. Scientist

Durham, NC · On-site

$94K - $121K/yr

Job Summary The Sr. Process Engineer/Senior Scientist will lead late-stage development activities for topical and liquid oral pharmaceutical products, including process scale-up, technology transfer ...

MedPharm

Sr. Process Engineer/Sr. Scientist

Durham, NC · On-site

$94K - $121K/yr

Job Summary The Sr. Process Engineer/Senior Scientist will lead late-stage development activities for topical and liquid oral pharmaceutical products, including process scale-up, technology transfer ...

Valspec

Process Validation Engineer

Raleigh, NC · On-site

$70 - $80/hr

... Life Sciences industry. Established in 1999, Valspec's mission is to provide a wide spectrum of ... Process Engineer -- Upstream / Downstream / Clean Utilities (Consultant) -- Contract Engagement:

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All JobsDownstream Process Development Scientist JobsFull Time Downstream Process Development Scientist JobsFull Time Downstream Process Development Scientist Jobs in Raleigh, NC

Full Time Downstream Process Development Scientist information

See Raleigh, NC salary details

$20

$37

$59

How much do full time downstream process development scientist jobs pay per hour?

As of Aug 20, 2026, the average hourly pay for full time downstream process development scientist in Raleigh, NC is $37.58, according to ZipRecruiter salary data. Most workers in this role earn between $27.60 and $44.86 per hour, depending on experience, location, and employer.

What does a full time downstream process development scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What are the key skills and qualifications needed to thrive as a full time downstream process development scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.

What are some typical challenges faced by a full time downstream process development scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

How much does a full time downstream process development scientist make?

In California, a full-time downstream process development scientist typically earns between $80,000 and $130,000 annually, depending on experience, education, and the specific employer. Salaries may also include benefits such as health insurance and bonuses, with higher compensation often associated with advanced skills in bioprocessing and laboratory techniques.

What is a full time downstream process development scientist?

A full-time downstream process development scientist specializes in designing, optimizing, and scaling the purification processes used in biopharmaceutical manufacturing, such as chromatography and filtration. They work to improve product yield, purity, and efficiency, often using laboratory techniques and process modeling tools, typically within a regulated environment requiring compliance with industry standards.

What are the most commonly searched types of Downstream Process Development Scientist jobs in Raleigh, NC?

The most popular types of Downstream Process Development Scientist jobs in Raleigh, NC are:

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For Full Time Downstream Process Development Scientist jobs in Raleigh, NC, the most frequently searched job titles are:

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The top searched job categories for Full Time Downstream Process Development Scientist jobs in Raleigh, NC are:

What cities near Raleigh, NC are hiring for Full Time Downstream Process Development Scientist jobs?

Cities near Raleigh, NC with the most Full Time Downstream Process Development Scientist job openings:

Full Time Downstream Process Development Scientist jobs near you
Infographic showing various Full Time Downstream Process Development Scientist job openings in Raleigh, NC as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 14% Part Time, and 2% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $78,175 per year, or $37.6 per hour.

Process Engineer II

AskBio

Durham, NC • On-site

Full-time

Posted 17 days ago

Job description

Opportunity for Secondment to AskBio
We're pleased to share an exciting secondment opportunity at AskBio.
This role is available for a time period to be determined by leadership at both Bayer and AskBio. While most assignments range from one to two years, the exact duration will be based on business needs and mutual agreement.
This secondment offers a unique chance to broaden your experience, expand your knowledge, and contribute meaningfully to AskBio's mission: to advance gene therapy and change the lives of patients around the world.
If you're interested in exploring this opportunity, we encourage you to:
  • Speak with your direct manager to discuss your interest and alignment with your development goals.
  • Apply directly using the link provided in the posting.

We look forward to seeing how our colleagues continue to grow and make an impact across the Bayer-AskBio partnership.
Our vision: Pioneering science to create transformative molecular medicines.
Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.
Our principles:
  • Advance innovative science by pushing boundaries.
  • Bring transformative therapeutics to patients in need.
  • Provide an environment for employees to reach their fullest potential.

Our values:
  • Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
  • Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
  • Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
  • Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
  • Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through.

Position Summary
AskBio is seeking a Process Engineer II to join our MSAT Process Engineering team and support current and future commercialization efforts. This position supports scale-up, technology transfer of AskBio's portfolio of gene therapy products into cGMP manufacturing for clinical production, process validation and commercial launch. The incumbent will onboard clinical programs into the MSAT laboratory, perform scale-up runs, and transfer programs to AskBio's contract manufacturing facility. Additionally, this position will be responsible for performing Phase III clinical enabling activities including scale-down model development and qualification, process characterization, and process control strategy definition to enable process performance qualification (PPQ) readiness for both drug substance and drug product manufacturing campaigns. This position is highly collaborative and will require internal and external team interactions to ensure successful process scale-up, technology transfers, and cGMP manufacturing operations to ensure continuity of supply while adhering to global regulations and standards.
This role is based on-site at our RTP (Research Triangle Park) Headquarters in NC and reports to an Associate Director, MSAT.
Job Responsibilities
  • Collaborate with cross-functional teams to transfer small-scale gene therapy processes from Process Development into the MSAT laboratory and subsequently perform scale-up and transfer to the cGMP manufacturing scale
  • Perform process characterization experiments to generate robustness data and define the process control strategy for PPQ manufacturing campaigns. Contribute to process characterization experimental design and data analysis
  • Develop and qualify small-scale models that are predictive of the cGMP manufacturing scale
  • Author technical protocols and reports to support experimental work and maintain clear, organized electronic laboratory notebooks
  • Provide effective communication of experimental results in technical presentations with internal stakeholders
  • Support investigations by contributing technical expertise to root-cause analyses and using a data-driven approaches for driving issue resolution
  • Ensure the laboratory is clean, organized and maintained in an efficient working order, includes scheduling routine preventative maintenance/calibration of instruments/equipment, securing supplies and materials for experiments, and proper scheduling of laboratory work

Minimum Requirements
  • Bachelor's Degree in a scientific discipline with 2+ years of Biopharmaceutical Experience; OR Master's Degree in a scientific discipline; OR High School Diploma with 6+ years of biopharmaceutical Experience
  • Hands-on upstream or downstream biomanufacturing laboratory experience
  • Excellent written and verbal communication skills, with experience interacting with a range of internal stakeholder groups
  • Proficiency in using Microsoft Office Suite (Word, Excel, PowerPoint)
  • Highly motivated, organized, and disciplined, with a strong desire to contribute as part of a best-in-class, collaborative tech transfer team
  • Adaptable and eager to learn, thriving in a fast-paced, highly interactive environment
  • Genuinely interested in building proficiency in upstream and downstream biomanufacturing operations, including process scale-up, technology transfer, process characterization, and process control strategy development
  • Continuous improvement-oriented, seeking opportunities to optimize process operations and performance through proactive problem solving
  • Open to domestic and international travel up to approximately 10%, as needed

Preferred Education, Experience and Skills
  • Prior downstream experience
  • Experience with viral vectors
  • Experience supporting cGMP manufacturing operations
  • Knowledge of the Design of Experiment (DOE) methodology with an ability to design, execute, and analyze experiments with oversight. JMP Statistical Software proficiency is highly preferred

AskBio Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job-related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at (919) 561-6210 or sending us an email at talent@askbio.com.

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