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Full Time Downstream Process Development Scientist Jobs in Raleigh, NC

Syngenta

Fermentation Scientist

Durham, NC

It will provide technical expertise to drive the development of microbial-based products from the ... or yeast) and downstream processing (e.g., centrifugation, filtration, freeze-drying)

Syngenta Group

Fermentation Scientist

Durham, NC · On-site

It will provide technical expertise to drive the development of microbial-based products from the ... or yeast) and downstream processing (e.g., centrifugation, filtration, freeze-drying)

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Full Time Downstream Process Development Scientist information

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How much do full time downstream process development scientist jobs pay per hour?

As of Jul 10, 2026, the average hourly pay for full time downstream process development scientist in Raleigh, NC is $37.58, according to ZipRecruiter salary data. Most workers in this role earn between $27.60 and $44.86 per hour, depending on experience, location, and employer.

What does a Full Time Downstream Process Development Scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

What are some typical challenges faced by a Downstream Process Development Scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What are the key skills and qualifications needed to thrive as a Full Time Downstream Process Development Scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.
What are the most commonly searched types of Downstream Process Development Scientist jobs in Raleigh, NC? The most popular types of Downstream Process Development Scientist jobs in Raleigh, NC are:
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Full Time Downstream Process Development Scientist jobs near you
Infographic showing various Full Time Downstream Process Development Scientist job openings in Raleigh, NC as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $78,175 per year, or $37.6 per hour.
Process Engineer - Solution Prep, Upstream, and Downstream

Process Engineer - Solution Prep, Upstream, and Downstream

Amgen, Inc.

Holly Springs, NC • On-site

Full-time

Posted 15 days ago

Job description

Career Category
Engineering
Job Description
Join Amgen's Mission of Serving Patients
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.
Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX batch facility will combine the latest in disposable technologies with traditional stainless steel equipment to allow for maximum flexibility in operations The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.
Process Engineer - Solution Prep, Upstream, and Downstream
What you will do
In this vital role you will be joining the Facilities & Engineering (F&E) group to partner closely with the corporate engineering team to design, build, commission, and qualify new equipment and systems needed for drug substance production as well as developing domain expertise to support operations upon start-up.
Site design, construction, start-up, and operational readiness:
  • Support the commissioning and qualification of manufacturing systems in alignment with GMP requirements and interact with regulatory inspectors.

  • Ensure systems are installed and operate safely and comply with pertinent environmental health/safety practice, rules and regulations.

  • Support commissioning and qualification of systems to ensure their operational capability is aligned with manufacturing requirements and GMP regulations.

  • Interact with regulatory inspectors as a manufacturing systems owner to communicate and demonstrate appropriate regulatory compliance of operating systems.

  • Assist with new product/technology introductions by performing engineering assessments, implementing equipment modifications, and supporting engineering runs.

Site Operations:
  • Provide system support for biopharmaceutical process equipment. Assist in identifying and implementing engineering-based improvements or upgrades to equipment or facility systems.

  • Support the development of business cases for improvements, identification of design requirements, and translation of these requirements into process equipment/system design, specifications, and supporting the construction, startup, and validation of improvements.

  • Develop equipment maintenance programs, ensure the availability of spare parts, and coordinate maintenance activities to ensure systems are in proper working order.

  • Provide system guidance to identify performance risks and implement risk reduction strategies.

  • Provide problem solving support to reduce production downtime. This includes supporting technical root cause analysis and implementation of corrective/preventive action.

  • Provide rotational on-call support and/or shift support based on business needs to ensure 24x7 day-to-day reliability of Solution Prep, Upstream and Downstream systems for plant operations.

  • On-site and up to 10% domestic/international travel.

What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The engineering professional we seek enjoys challenges and is motivated to help serve patients with these qualifications.
Basic Qualifications:
Master's degree
OR
Bachelor's degree and 2 years of Engineering experience
OR
Associate's degree and 6 years of Engineering experience
OR
High school diploma / GED and 8 years of Engineering experience
Preferred Qualifications:
  • Bachelor' s degree in Chemical or Mechanical Engineering or similar engineer discipline.

  • 3+ years' of relevant work experience with 2+ years' experience in Biopharmaceutical operations/manufacturing environment

  • Direct knowledge of design and troubleshooting with GMP Biopharmaceutical Production facility equipment/systems with direct experience with Solution Prep, Upstream, and Downstream purification equipment such as weigh and dispense equipment, solution preparation vessels, cell culture reactors, centrifugation, chromatography, viral filtration skids, and UFDF skids as well as other equipment needed to support these processes such as autoclaves, clean in place (CIP) systems, washers, clean steam, water for injection, etc.

  • Ability to analyze problems, develop and propose engineering solutions in a scientific manner using data-driven techniques and analyses (e.g., Data Analytics, Root Cause Analysis (RCA), Statistical Process Control (SPC), Six Sigma, Predictive Maintenance, etc.)

  • Experience working in a regulated environment (e.g. cGMP, OSHA, EPA, etc.) and familiarity with GMP quality systems/processes such as change control, non-conformances, corrective and preventative actions, and qualifications/validation

  • Experience applying engineering principles to the design and implementation of system modifications, introduction of new processes, and the oversight of capital projects

  • Understanding of capital projects in a GMP Biopharmaceutical Production facility including procurement, construction, startup, and validation

  • Understanding of safety requirements working in a GMP Biopharmaceutical Production facility.

  • Independent, ambitious, organized, able to multi-task in project environments, and skilled in communication, facilitation, and teamwork

  • Collaborative teammate prepared to work in and embrace a team based environment that relies on communication for effective decision-making

  • Strong leadership, technical writing, and communication/presentation skills

  • Work schedule flexibility as required to support 24/7 operations, requiring occasional after hours engineering coverage

  • Ability for domestic/international travel.

What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.
Apply now and make a lasting impact with the Amgen team!
careers.amgen.com
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Salary Range
88,281.00USD -119,439.00 USD

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