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Full Time Downstream Process Development Scientist Jobs in Raleigh, NC

Novartis

Scientist - Upstream Cell Culture

Durham, NC · On-site

$93K - $174K/yr

The Expert, Science & Technology - Upstream/Cell Culture, is responsible for cell & gene therapy ... Contributes to process risk assessments. Justifies development strategies and experiment designs.

New

KBI Biopharma, Inc.

Scientist I

Durham, NC · On-site

$84K - $115K/yr

Collaborate cross-functionally with process development, manufacturing, program management, data review, and quality assurance teams. * Mentor and train junior scientists and associates. * Perform ...

KBI Biopharma, Inc.

Scientist I

Durham, NC · On-site

$84K - $115K/yr

Collaborate cross-functionally with process development, manufacturing, program management, data review, and quality assurance teams. * Mentor and train junior scientists and associates. * Perform ...

Valspec

Process Engineer Consultant

Raleigh, NC · On-site

... Life Sciences industry. Established in 1999, Valspec's mission is to provide a wide spectrum of ... Support commissioning, startup, and qualification activities for upstream and/or downstream ...

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Full Time Downstream Process Development Scientist information

See Raleigh, NC salary details

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$37

$59

How much do full time downstream process development scientist jobs pay per hour?

As of Aug 20, 2026, the average hourly pay for full time downstream process development scientist in Raleigh, NC is $37.58, according to ZipRecruiter salary data. Most workers in this role earn between $27.60 and $44.86 per hour, depending on experience, location, and employer.

What does a full time downstream process development scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What are the key skills and qualifications needed to thrive as a full time downstream process development scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.

What are some typical challenges faced by a full time downstream process development scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

How much does a full time downstream process development scientist make?

In California, a full-time downstream process development scientist typically earns between $80,000 and $130,000 annually, depending on experience, education, and the specific employer. Salaries may also include benefits such as health insurance and bonuses, with higher compensation often associated with advanced skills in bioprocessing and laboratory techniques.

What is a full time downstream process development scientist?

A full-time downstream process development scientist specializes in designing, optimizing, and scaling the purification processes used in biopharmaceutical manufacturing, such as chromatography and filtration. They work to improve product yield, purity, and efficiency, often using laboratory techniques and process modeling tools, typically within a regulated environment requiring compliance with industry standards.

What are the most commonly searched types of Downstream Process Development Scientist jobs in Raleigh, NC?

The most popular types of Downstream Process Development Scientist jobs in Raleigh, NC are:

What are popular job titles related to Full Time Downstream Process Development Scientist jobs in Raleigh, NC?

For Full Time Downstream Process Development Scientist jobs in Raleigh, NC, the most frequently searched job titles are:

What job categories do people searching Full Time Downstream Process Development Scientist jobs in Raleigh, NC look for?

The top searched job categories for Full Time Downstream Process Development Scientist jobs in Raleigh, NC are:

What cities near Raleigh, NC are hiring for Full Time Downstream Process Development Scientist jobs?

Cities near Raleigh, NC with the most Full Time Downstream Process Development Scientist job openings:

Full Time Downstream Process Development Scientist jobs near you
Infographic showing various Full Time Downstream Process Development Scientist job openings in Raleigh, NC as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 14% Part Time, and 2% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $78,175 per year, or $37.6 per hour.

Manager Manufacturing Programs - Process Owner Team

Amgen

Holly Springs, NC

Full-time

Re-posted 7 days ago

Job description

Career CategoryManufacturingJob Description

HOW MIGHT YOU DEFY IMAGINATION?

If you feel likeyou'repart of something bigger,it'sbecause you are. At Amgen, our shared mission-to serve patients-drives all that we do. Be part of Amgen North Carolina's newest and most advanced drug substance manufacturing facility, combining single-use technologies, traditional processing equipment, Industry 4.0 capabilities, and sustainability innovations.

Manager Manufacturing Programs - Process Owner Team

Live

What You Will Do

In this vital role, you will lead a team of Process Owners within the Manufacturing Support organization at Amgen North Carolina (ANC). This position may lead either an Upstream & Services-focused team or a Downstream-focused team and requires strong technicalexpertisein the applicable manufacturing area combined withdemonstratedpeopleleadership capabilities.

The Process Owner Team serves as a critical technical interface between Manufacturing Operations and support organizations, ensuring manufacturing processes are effectively translated into operational execution, manufacturing procedures, and digital manufacturing workflows. The team provides technical process stewardship, manufacturing floor support, operational readiness, CAPA implementation support, manufacturing change management, and procedural governance to enable safe, compliant, and reliable manufacturing operations.

  • Lead, coach, develop, and manage a team of Process Owners supporting GMP drug substance manufacturing operations.

  • Foster a culture of safety, quality, compliance, accountability, collaboration, and continuous improvement.

  • Provide leadership for technical process stewardship, manufacturing support, operational readiness, and process governance activities.

  • Ensure Process Owners provide effective floor support,hypercare, troubleshootingassistance, and manufacturing execution support.

  • Oversee operational readiness activities including water runs, dry runs, equipment readiness verification, and Electronic Batch Record (EBR) testingsupport.

  • Drive accountability for execution andtimelyclosure of Process Owner commitments associated with CAPAs, risk assessments, investigation support activities, change controls, and operational readiness activities.

  • Lead manufacturing-related change control implementation activitiesimpactingmanufacturing operations (excluding NPI-related change controls).

  • Ensure manufacturing processes are effectively translated into SOPs, manufacturing workflows, training materials, and associated digital manufacturing processes.

  • Partner with Manufacturing, Process Development, Quality, Engineering, Supply Chain, Facilities & Engineering, and Digital Manufacturingto support facility fit assessments, process overviews, process implementation, and continuous improvement initiatives.

  • Support BOM readiness activities and alignment of single-use assemblies, consumables, and process materials with manufacturing requirements.

  • Ensureappropriate escalationand communication of manufacturing, quality, compliance, and operational risks.

  • Supportinspectionreadiness activities and represent the Process Owner organization during audits and regulatory inspections.

Win

What We Expect of You

Basic Qualifications

  • Doctorate degree OR

  • Master's degree and3years of biotechnology or pharmaceutical manufacturing experience OR

  • Bachelor's degree and5years of biotechnology or pharmaceutical manufacturing experience OR

  • Associate's degree and 10 years of biotechnology or pharmaceutical manufacturing experience OR

  • High school diploma / GED and 12 years of biotechnology or pharmaceutical manufacturing experience

  • In addition to meeting at least one of the above requirements, you must have experience directly managing people and/or leadership experience leadingteams, projects,prograns, or directing the allocationorresources. Your managerial experience may run concurrently with the required technical experience referenced above

Preferred Qualifications

  • 7+ years of biotechnology or pharmaceutical manufacturing experience with progressively increasing responsibility.

  • Demonstratedpeopleleadership experience managing, coaching, and developing technical teams.

  • Strong technicalexpertisein either Upstream & Services manufacturing operations or Downstream manufacturing operations.

  • Experience with GMP manufacturing operations, process stewardship, and manufacturing support.

  • Experience supporting operational readiness activities, including water runs, dry runs, equipment testing, and startup support.

  • Experience with CAPA implementation, CAPA applicability assessments, effectiveness checks, risk assessments, and root cause analysis support.

  • Knowledge of drug substance manufacturing equipment, process flows, and manufacturing operations.

  • Experience supporting Manufacturing Execution Systems (MES) and Electronic Batch Records (EBRs) within a GMP manufacturing environment.

  • Knowledge of single-use technologies and Bill of Material (BOM) structures.

  • Experience partnering with Process Development on facility fit assessments, process implementation, and knowledge transfer activities.

  • Strong communication, organizational, and cross-functional leadership skills.

Thrive

As we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being through comprehensive benefits, career development opportunities, and a collaborative culture.

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