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How much do downstream process development jobs pay per hour?

As of May 30, 2026, the average hourly pay for downstream process development in the United States is $33.68, according to ZipRecruiter salary data. Most workers in this role earn between $27.64 and $41.35 per hour, depending on experience, location, and employer.

What is a Downstream Process Development job?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What are the key skills and qualifications needed to thrive in the Downstream Process Development position, and why are they important?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What are typical daily responsibilities for someone in Downstream Process Development?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.
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Downstream Process Development jobs near you
Director, Downstream Process Development

Director, Downstream Process Development

Allakos

Redwood City, CA

Full-time

Posted 18 days ago

Job description

Director, Downstream Process Development
Allakos Inc. is a clinical-stage company developing therapeutic antibodies for inhibitory receptors on the surface of immune effector cells involved in allergic, inflammatory and proliferative diseases.
Allakos is committed to developing innovative therapies that transform patients’ lives. We are looking for bright and talented individuals to join our team and share in our passion and commitment to improving the lives of patients.
Position Summary:
The Director, Downstream Process Development would be key member of Biologics DS development and tech transfer team and would be responsible for all activities related to Downstream Process Development of our late-stage clinical biologics (Mab) molecule AK002 and early stage program. This position leads the Purification Group which is responsible for the process development, tech transfer, supervision of Engineering and Clinical batches, BLA enabling activities, PPQ Batches and commercial production at multiple CMO sites, process characterization and BLA authoring and review.
Your Role:
  • Provide technical and managerial leadership to the Downstream Process Development group and technology transfer of AK002 process to CMO sites.
  • Accountable for all activities pertaining to the downstream process development lab. Supervise planning and execution of experiments. Analyze results and communicate it effectively to management.
  • Coordinate with Upstream development, Analytical and Facilities department to successfully complete the DSP activities
  • Provide overall strategy and experimental plan for downstream process characterization studies. Generate protocols, supervise execution, use statistical tools to analyze results and review reports for studies.
  • Plan the downstream process development experiments for new molecules and supervise execution of the same.
  • Supervise the Engineering and Clinical batches at the CMOs, Review and approve Batch records, Bill of Materials, Bill of Parameters, Batch records, deviations and CAPA documents for these batches
  • Plan and supervise PPQ batches at CMOs. Review and approve protocols and reports for PPQ batches
  • Author and review BLA submission documents
  • Lead cross functional meetings with Quality, Regulatory, Supply Chain, Process Development, Analytical and Drug Product to build consensus on key issues and facilitate decision making to move the project forward
  • Travel domestically and internationally up to 10% of the time
Qualifications and Expertise:
  • At least 15 years of relevant experience (12+ with MS, 10+ for PhD) successfully working in biopharmaceutical industry with proven track record of leadership and success
  • At least 8 years managing cross functional projects and leading teams
  • Extensive experience in Downstream process development and process characterization of biologics molecules such as Mabs and fusion proteins.
  • Experience in technology transfer and facility fit assessments
  • Should have worked with early and late stage and commercial biologics with experience in process development, process characterization, PPQ batches and other BLA enabling studies and CPV programs.
  • Experience working with Contract Manufacturers is preferred.
  • Experienced in BLA submission write ups.
  • Experience in people and stakeholder management, conflict resolution and building consensus.
  • Good understanding of cGMP-regulations including relevant US/EU regulatory and quality requirements, practices, and standards.
  • Exceptional interpersonal skills to establish positive relationships with internal stakeholders, CROs/CMOs, and multi-functional/multi-cultural teams.
  • Ability to travel at least 10% of the time.
The salary is competitive and commensurate with experience and qualifications.
The Allakos Values are: Selflessness, Drive, Clarity, Thoughtfulness, Fun, and Leadership
Allakos is an equal opportunity employer. Allakos will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or
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About Allakos

Sourced by ZipRecruiter

Industry

Biotechnology research and development

Company size

51 - 200 Employees

Headquarters location

Redwood City, CA, US

Year founded

2012

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