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Downstream Process Development Jobs in Virginia (NOW HIRING)

Apex Systems

Business Process Analyst

Richmond, VA · On-site

$60.40K - $81.10K/yr

... downstream usage. * Testing & validation: Support SIT/UAT planning and execution; develop test ... We offer quality career resources, training, certifications, development opportunities, and a ...

10Pearls LLC

SAP Ariba Technical Lead

Vienna, VA · On-site

Assists customers in the development of processes and procedures which leverage Ariba solution ... In depth understanding of ARIBA upstream and downstream processes * Knowledge of backend ...

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$18

$33

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How much do downstream process development jobs pay per hour?

As of May 28, 2026, the average hourly pay for downstream process development in Virginia is $33.39, according to ZipRecruiter salary data. Most workers in this role earn between $27.40 and $41.01 per hour, depending on experience, location, and employer.

What is a Downstream Process Development job?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What are the key skills and qualifications needed to thrive in the Downstream Process Development position, and why are they important?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What are typical daily responsibilities for someone in Downstream Process Development?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.
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Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Virginia as of May 2026, with employment types broken down into 78% Full Time, and 22% Contract. Highlights an 83% In-person, and 17% Remote job distribution, with an average salary of $69,460 per year, or $33.4 per hour.
Director, Vector Production

Director, Vector Production

Sangamo Therapeutics

Richmond, VA • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

This job post has expired today. Applications are no longer accepted.

Job description

JOB SUMMARY:
The Director, Vector Production will oversee activities related to the Process Development and in-house non-GMP/cGMP production of recombinant Adeno-associated Viral Vectors (rAAV), and cGMP vector production at contract manufacturing organizations (CMOs).
ESSENTIAL FUNCTIONS:
  • Manage the Process Development, GMP production, testing and fill finish of rAAV products at CMO's
  • Manage internal activities related to the scale-up and production of rAAVs in house for use in R&D and pending facility decisions
  • Lead in-house team producing rAAV
  • Co-ordinate production activities with research, non-clinical development, QA, QC and clinical development
  • Ensure the ongoing security of the supply chain for raw materials and intermediates to ensure the uninterrupted performance of rAAV operations
  • Co-ordinate the transfer, qualification and implementation of process improvements and scale-up
  • Lead the reporting, investigation and resolution of deviations encountered during GMP production activities
  • Participate in the design, construction and commissioning of company manufacturing facilities
  • Other activities as may be assigned

EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:
The ideal candidate for this position will have in-depth experience of the large-scale cGMP production of rAAV, including upstream cell culture, downstream processing, and fill finish operations.
Candidate must possess:
  • MS or Ph.D in bioprocessing, chemical engineering, vector biology, or biological sciences
  • Minimum of 10 years experience in the biotechnology or pharma industry with a primary focus on upstream cell culture process development and manufacturing operations for biologics
  • Proven track record of managing in-house and CMO GMP production operations
  • In-depth experience with:
    • Mammalian cell, insect cell and microbial cell culture systems at both pilot-scale and at large-scale
    • Different bioreactor production systems and scales, including disposable-based culture systems
    • CIP, SIP, WFI
  • In-depth knowledge of FDA, EMA, GMP and ICH regulatory requirements
  • Knowledge of Quality Systems and QBD as they relate to GMP production operations and process optimization
OTHER REQUIREMENTS:
  • Experience of facility, and production equipment design and validation, including IQ, OQ & PQ a plus
  • Proven managerial skills
  • Outstanding organizational skills
  • Excellent written and oral communication skills
  • Ability to operate in a fast-paced, multi-disciplinary industrial environment

The successful candidate will enjoy a competitive base salary and the opportunity to participate in incentive compensation programs, including bonus and stock option plans. Sangamo offers a comprehensive benefits program, including: medical, dental and vision care; paid vacation and holiday time; access to a voluntary 401(k) and Employee Stock Purchase Plan. Sangamo is an equal opportunity employer.

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