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Downstream Process Development Jobs in Massachusetts

Amgen

Process Development Associate

Cambridge, MA · On-site

Process Development Associate What you will do Let's do this. Let's change the world. In this vital ... and downstream manufacturing processes supporting Ph II/III clinical trials to marketing ...

CEDENT

Senior Scientist, Process Development

Watertown, MA

$99K - $135K/yr

We are seeking a Senior Scientist, Process Development, responsible for executing cell culture experiments, downstream processing, analyzing data, and contributing to process development projects.

Managed Staffing

Purification Scientist

Boston, MA · On-site

$44 - $46/hr

Monday-Friday | 8:00 AM-5:00 PM (40 hrs/week Position Summary Seeking an early-career Biologist / Purification Scientist to join the Downstream Process Development team in Boston, MA. This role will ...

Adecco

Research Associate II

Waltham, MA

Adecco Healthcare & Life SciencesSenior Research Associate - Downstream Process Development (Protein Purification) Fully Onsite | Waltham, MA | Temp Opportunity Pay: Up to 54/hr depending on relevant ...

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Downstream Process Development information

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$20

$36

$54

How much do downstream process development jobs pay per hour?

As of Jun 22, 2026, the average hourly pay for downstream process development in Massachusetts is $36.79, according to ZipRecruiter salary data. Most workers in this role earn between $30.19 and $45.14 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Process Development position, and why are they important?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What is a Downstream Process Development job?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What are typical daily responsibilities for someone in Downstream Process Development?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are popular job titles related to Downstream Process Development jobs in Massachusetts? For Downstream Process Development jobs in Massachusetts, the most frequently searched job titles are:
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What cities in Massachusetts are hiring for Downstream Process Development jobs? Cities in Massachusetts with the most Downstream Process Development job openings:
Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Massachusetts as of June 2026, with employment types broken down into 79% Full Time, 6% Part Time, 4% Temporary, 9% Contract, and 2% Nights. Highlights an 93% In-person, 2% Hybrid, and 5% Remote job distribution, with an average salary of $76,515 per year, or $36.8 per hour.

DOWNSTREAM PROCESS DEVELOPMENT SCIENTIST

MyGradJob

Billerica, MA

Other

Posted 28 days ago

Job description

Company Description

MilliporeSigma is the North American life science brand of Merck KGaA, Darmstadt, Germany - a leading science and technology company. It offers a broad range of innovative products and services to biotech and pharmaceutical drug therapies businesses. Through dedicated collaboration with the scientific and engineering communities, and as one of the top three R&D investors in the life science tools industry, the brand serves as a strategic partner to customers and helps advance the promise of life science.

Job Description
  • Design fit-for-purpose purification experiments according to the stage of development
  • Ensure scientific evaluation of impact of deviations to Downstream validation studies
  • Compile and analyze experimental data to generate process knowledge and decide on next steps
  • Write development and validation reports and ensure their timely delivery
  • Prepare and present project updates to global project team and to upper management
  • Ensure a continuous improvement within Downstream process development activities
  • Represent & promote E2E and Biodevelopment activities (presentations, congresses, events)
  • Technical lead on the overall projects (supervises Downstream processes development and implementation of new methods and services)
  • Technical leader for equipment, technologies for Downstream process development
  • Responsible for activities ranging from protein purification, filtration, biochemical and biophysical characterization of proteins: -
  • Execute routine protein purification with affinity, size exclusion, ion exchange, and hydrophobic interaction chromatography using AKTA systems (Unicorn software)
  • Perform analyses including but not limited to SDS-PAGE, SE-HPLC, LAL, host cell-DNA, host cell protein, as necessary
  • To develop, validate and transfer robust analytical methods required for successful drug development and manufacturing.
  • To support follow-up and troubleshooting on analytical methods.
  • Provide expertise and insight to guide development of appropriate purification methods
  • Develop novel purification processes as well as using standard methods to purify proteins from the mg to gram scale. Processes will be multiple steps and must provide necessary clearance of viruses, endotoxin, and host cell proteins and DNA.
  • Perform, develop and optimize robust, efficient, scalable strategies for improving process performance. Activities will include small-scale studies and pilot scale purification studies.
  • Apply DOE methods to purification activities
Qualifications
  • Engineering/Master degree (PhD preferred) in biotechnology with 5+ years in the biopharmaceutical industry
  • Solid and proven theoretical basis and hands-on experience in protein purification and analytical characterization
  • Hands-on experience with purification unit operations including filtration, chromatography, TFF, UF/DF, AKTA, UNICORN and HPLC systems.
  • Strong hands-on experience in troubleshooting and routine instrument maintenance.
  • Experienced in protein purification via affinity, hydrophobic interaction (HIC), ion exchange (IEX), size exclusion (SEC) and mixed-mode chromatography
  • Knowledge and skills in biochemical characterization of proteins including analytical and biophysical
  • Proven track record in Purification Process Development is necessary with emphasis on chromatographic separations and excellent understanding of and experience with chromatographic resin screening and process optimization.  Experience with scale-up and GMP manufacturing is desirable.
  • Solid and proven working knowledge of DOE. Ability to critically analyze data using statistical tools and to compile technical reports
  • Excellent presentation and communication skills
  • Results-oriented with ability to work and deliver under pressure
  • Excellent English (written, oral) 
Additional Information

All your information will be kept confidential according to EEO guidelines.

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