ZipRecruiter

Log In

1

Downstream Process Development Jobs in Massachusetts

Integrated Resources INC

Biprocess Engineer

Devens, MA · On-site

D.: 0 - 2 years; BS/MS: 2 - 6 years) in process development, process validation or manufacturing support in bioprocessing (upstream and/ or downstream) * Preferred: Prior experience scaling up ...

Integrated Resources INC

Process Engineer

Lexington, MA · On-site

... downstream processes of commercial productions and late stage clinical process development and productions. The scope of work will include designing studies under instruction, executing experiments ...

next page

Showing results 1-20

All JobsDownstream Process Development JobsDownstream Process Development Jobs in Massachusetts

Downstream Process Development information

See Massachusetts salary details

$20

$36

$54

How much do downstream process development jobs pay per hour?

As of Jun 22, 2026, the average hourly pay for downstream process development in Massachusetts is $36.79, according to ZipRecruiter salary data. Most workers in this role earn between $30.19 and $45.14 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Process Development position, and why are they important?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What is a Downstream Process Development job?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What are typical daily responsibilities for someone in Downstream Process Development?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are popular job titles related to Downstream Process Development jobs in Massachusetts? For Downstream Process Development jobs in Massachusetts, the most frequently searched job titles are:
What job categories do people searching Downstream Process Development jobs in Massachusetts look for? The top searched job categories for Downstream Process Development jobs in Massachusetts are:
What cities in Massachusetts are hiring for Downstream Process Development jobs? Cities in Massachusetts with the most Downstream Process Development job openings:
Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Massachusetts as of June 2026, with employment types broken down into 79% Full Time, 6% Part Time, 4% Temporary, 9% Contract, and 2% Nights. Highlights an 93% In-person, 2% Hybrid, and 5% Remote job distribution, with an average salary of $76,515 per year, or $36.8 per hour.

Process Engineer, Pharmaceutical

Open roles at Optimyze1

Boston, MA

$120K - $130K/yr

Full-time

Posted 26 days ago

Job description


We're hiring a Process Development Sales Engineer to work with industrial customers to support the deployment of AI-driven solutions in technical and operational environments.


This is a cross-functional role that combines engineering, customer collaboration, data analysis, and technical problem-solving. You'll work with a range of stakeholders to understand operational challenges, analyze process and production data, develop models and workflows, and help drive improvements using the company's platform.


The ideal candidate is comfortable engaging with technical teams, working with data and analytical tools, and translating technical findings into practical business outcomes.


Internally, you'll act as a technical subject matter expert and advocate for customer needs across manufacturing and process-related initiatives.


Externally, you'll support enterprise customers by partnering with engineering and operations teams to maximize value from the platform, whether by improving existing workflows or helping implement new solutions.


In collaboration with Sales, Product, and Engineering, you'll also contribute to identifying new use cases and shaping future platform capabilities.


What You'll DoCustomer Engagement & Project Delivery
  • Partner with customers to support deployment and adoption of platform solutions
  • Lead onboarding and implementation efforts across technical and operational environments
  • Build relationships with engineering, operations, and leadership stakeholders
  • Identify opportunities for operational improvement and data-driven insights
  • Translate customer challenges into actionable technical solutions and product feedback
  • Support projects from discovery through implementation and impact measurement
Technical Analysis & Problem Solving
  • Analyze operational and process datasets to identify trends, bottlenecks, and optimization opportunities
  • Develop analytical models, simulations, and workflows using Python and related tools
  • Work with industrial data systems and manufacturing datasets
  • Collaborate with product and engineering teams to improve platform functionality
  • Communicate technical findings to both technical and non-technical audiences
  • Support troubleshooting and continuous improvement initiatives in complex operational settings
What You'll Need
  • 5-7 years of experience in manufacturing, process engineering, or related industrial environments
  • Experience developing and applying first-principles (physics-, chemistry-, and biology-based) models of bioprocesses and biologics manufacturing operations. Candidates should have demonstrated experience building mechanistic models from fundamental transport, reaction, thermodynamic, kinetic, and cellular processes rather than purely empirical or machine-learning approaches.

Examples may include:

• Upstream bioprocess modeling (cell culture, microbial fermentation, metabolic and growth kinetics, nutrient consumption, product formation)

• Downstream process modeling (chromatography, filtration, UF/DF, precipitation, mixing, mass transfer, adsorption, and purification operations)

• Digital twins and process simulations for biologics manufacturing facilities

• Scale-up and scale-down modeling based on transport phenomena and bioprocess fundamentals

• Mechanistic modeling for process optimization, control, technology transfer, capacity planning, or process development

Preferred qualifications:
• Experience implementing models in MATLAB, Python, gPROMS, Aspen Custom Modeler, COMSOL, Julia, or similar platforms
• Experience supporting commercial manufacturing, process development, or manufacturing science and technology (MSAT) teams
• Ability to derive, calibrate, validate, and interpret mechanistic models using experimental and manufacturing data