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Downstream Process Development Jobs in Philadelphia, PA

CEDENT

Process Scientist

Philadelphia, PA · On-site

... developed process to GMP manufacturing. A Scientist is a mid-level individual with understanding of cell/molecular biology and previous experience in either upstream or downstream biopharmaceutical ...

Globus Medical

Analytical Scientist

Audubon, PA · On-site

Collaborate cross-functionally with upstream/downstream process development, formulation, and quality teams to support CMC development. * Analyze and interpret complex data, provide scientific ...

Globusmedical

Analytical Scientist

Audubon, PA

Collaborate cross-functionally with upstream/downstream process development, formulation, and quality teams to support CMC development. * Analyze and interpret complex data, provide scientific ...

Steel Partners

Product Development Chemist

Bristol, PA · On-site

... activities to downstream team members. This position serves as the technical authority for ... Standardized Product & Process Optimization * Identify and prioritize optimization opportunities ...

Dunmore

Product Development Chemist

Bristol, PA · On-site

... activities to downstream team members. This position serves as the technical authority for ... Standardized Product & Process Optimization * Identify and prioritize optimization opportunities ...

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How much do downstream process development jobs pay per hour?

As of May 28, 2026, the average hourly pay for downstream process development in Philadelphia, PA is $33.99, according to ZipRecruiter salary data. Most workers in this role earn between $27.88 and $41.73 per hour, depending on experience, location, and employer.

What is a Downstream Process Development job?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What are the key skills and qualifications needed to thrive in the Downstream Process Development position, and why are they important?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What are typical daily responsibilities for someone in Downstream Process Development?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.
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Downstream Process Development jobs near you

(Sr) Technician, Downstream Process

GenScript/ProBio

Pennington, NJ

$60K - $75K/yr

Other

Posted 15 days ago

Job description

About ProBio:

ProBio, a subsidiary of GenScript, is a global CDMO offering end-to-end services from discovery to GMP for plasmids, antibodies, and cell & gene therapies. We bring together multidisciplinary expertise to accelerate development and manufacturing through customized, and comprehensive services. ProBio has established companies in the United States, the Netherlands, South Korea, and China (Hong Kong, Shanghai, and Nanjing) and other regions to serve global customers, and has helped customers in the United States, Europe, Asia Pacific and other regions obtain more than 150 IND approvals since October 2017.

About the job:

The (Sr) Technician, Downstream Process will work within the Downstream Processing group and performs the following activities while executing Downstream operations:

  • Preparation of stock solutions, and buffers.
  • Filtration of stock solutions and buffers.
  • Operates all production equipment in assigned functional area such as single use chromatography systems, chromatography columns, other disposable Bioprocess equipment, and solution preparation equipment as per written procedures.
  • The (Sr) Technician, Downstream Process supports relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.

Location: Pennington, NJ

Responsibilities:

  • Executes routine complex manufacturing assignments per written procedures; recognizes deviations from procedures and raises issue to management for resolution.
  •  Adheres to current Good Manufacturing Practices (cGMP) and Standard Operating Procedures (SOPs).
  • Performs routine microbial and mammalian purification. Monitors chromatography and tangential flow filtration (TFF) systems during processing.
  • Weighs and checks raw materials, assembles process equipment, and monitors processes.
  • Completes work instructions and maintains clean room environment to comply with regulatory requirements
  • Operates all production equipment in assigned functional area such as single use chromatography systems, chromatography columns, other disposable Bioprocess equipment, and solution preparation equipment as per written procedures.
  • Authors solution preparation Master Batch Records (MBRs) by transferring technical information from scientific and development documents.
  • Proposes and routes revisions to existing SOP's for functional area equipment.
  • Works to become proficient on common bioprocessing equipment.
  • Conducts Safety and GMP self-auditing walkthroughs, documenting observations for assignment and closure dates. Tracks and ensures closure of observations. 
  • Logs and submits samples in Laboratory Information Management System (LIMS); tracks results and compiles data.
  • Reviews own work for completeness on executed Master Batch Records (MBRs).
  • Coordinate the tracking and return of executed records to Quality department for review.
  • Coordinates with Logistics to ensure needed materials are delivered to the production area timely. Monitors future needs against material supply to alert Logistics of shortfalls.
  • Performs other tasks and assignments as needed and specified by management.

Qualifications:

  • Bachelor's degree in science or engineering with a 0 - 5 years relevant experience or an Associate's degree in science or engineering with a minimum of 3 years relevant experience or a High school diploma with a minimum of 7 years relevant experience.
  • Demonstrated ability to follow written instructions and procedures.
  • Demonstrated ability to pay strict attention to detail.
  • Proficiency with Microsoft Office.
  • Excellent verbal and written communication and skills.
  • Ability to work collaboratively as part of a team, in a fast-paced, matrixed, team environment consisting of internal and external team members.

The estimated pay range for the role is between $60,000 - $75,000 based on qualifications and experience.

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