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Downstream Process Development Jobs in Philadelphia, PA

Wood Plc

Senior Process Engineer

Philadelphia, PA · On-site +1

$104K - $135K/yr

A key contributor on process engineering design teams (upstream, downstream, utilities, fill ... Participating in project planning, cost development, and project scheduling * Maintaining effective ...

Marsh McLennan

Senior Enterprise Architect

Lansdale, PA · On-site

... downstream process dependencies across core servicing, transaction, and operational workflows ... Manage the development of supporting application components, interface/design of systems as well as ...

Morgan Properties

Senior Software Engineer

Conshohocken, PA · On-site

$120K - $159K/yr

... development and performance tuning, and production-grade React applications supporting data ... downstream processes. In addition, the role contributes to architectural design discussions ...

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Downstream Process Development information

See Philadelphia, PA salary details

$19

$33

$49

How much do downstream process development jobs pay per hour?

As of Sep 12, 2026, the average hourly pay for downstream process development in Philadelphia, PA is $33.99, according to ZipRecruiter salary data. Most workers in this role earn between $27.88 and $41.73 per hour, depending on experience, location, and employer.

What is downstream process development?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What does someone in downstream process development do?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are the key skills and qualifications needed for downstream process development?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What are popular job titles related to Downstream Process Development jobs in Philadelphia, PA?

For Downstream Process Development jobs in Philadelphia, PA, the most frequently searched job titles are:

Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Philadelphia, PA as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 81% Full Time, 15% Part Time, and 2% Contract. Highlights an 86% Physical, 3% Hybrid, and 11% Remote job distribution, with an average salary of $70,697 per year, or $34 per hour.

Mechanical Engineer III

Philadelphia, PA • On-site

Hargrove Engineers and Constructors
Industrial Automation Equipment Manufacturing • 51 - 200 employees
Learn more about Hargrove Engineers and Constructorsexternal

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 10 hours ago

Job description

What You'll Be Doing
Job Scope: Generally responsible for conceptual through detailed design for manufacturing facilities in the biopharmaceutical and specialty chemical industries. Responsible for coordinating and specifying both upstream and downstream process equipment as well as collaborating with all engineering disciplines. Responsible for supporting the procurement of process systems for technical reviews, equipment inspection and construction support. This work will be performed in an engineering environment that requires knowledge with ASME BPE standards, FDA/GMP compliance and other international standards. This work will be performed under general supervision.
Primary responsibilities will include but not be limited to:
  • Familiarity with department design and drafting standards.
  • Familiarity with project scope, specifications and design criteria upon assignment to a project task team.
  • On-site assistance during startup, as needed.
  • Accomplishing engineering activities such as construction specifications, material procurement specifications, calculations and piping estimates.
  • Developing conceptual layouts and cost studies as necessary to determine the simplest, most efficient approach to solving engineering tasks at hand.
  • Producing estimate level preliminary designs and material take-offs suitable for the level of the estimate being performed on a project.
  • Producing detail design calculations and sketches for materials of construction associated with the project. Calculations produced will be neatly prepared and organized for efficient checking by others and efficient use by drafters/designers for preparing drawings and as a deliverable when required.
  • Assisting the drafting group in resolving routine layout and detailing problems. It is your responsibility to furnish sufficient sketches and details necessary for completion of engineering drawings.
  • Consulting with design leaders from other disciplines to ensure the smooth flow of vital information necessary for the scheduled completion of the project.
  • Reviewing and checking vendor drawings and other discipline drawings for mechanical input.
  • Advising the senior engineer concerning design or scope changes, which have been identified.
  • Assisting other engineers in developing and assembling scopes, drawings and specifications into a "package" for mechanical purchase inquiries issued for procurement of equipment, materials or subcontract pricing.
  • Developing construction specifications.
  • Reviewing fabrication drawings and other construction submittals for conformance to engineering drawings and specifications.
  • Performing fieldwork necessary to gather field data, check tie-ins and provide construction support.
  • Provide technical guidance to less experienced drafting and engineering personnel in the department.
  • Knowledgeable of the discipline specific methods, practices and techniques required to engineer, design and construct process and manufacturing projects.
  • Recognize and communicate scope and design changes promptly.
  • Coordinate work activities with other teammates and the discipline lead.
  • Applying advanced engineering techniques and analysis to complex designs.
  • Complete understanding of the skills and experience required to perform engineering and design functions.
  • Ability to identify and develop work sharing packages for interoffice execution support. Provide leadership to ensure communication and execution of work within scope, schedule and budget.

Ideal Background
Education: Bachelor or Master of Science degree in Mechanical Engineering from an accredited university is required.
Registration: Professional Engineering registration is highly preferred.
Experience: This position requires 6 to 10 years of relevant biopharmaceutical or chemical manufacturing experience in mechanical engineering.
Required Knowledge, Skills, and Abilities:
  • Knowledge of design standards and codes.
  • Knowledge, application and specification of materials.
  • Development of piping material and material procurement specifications.
  • Knowledge of good design practices for sizing all piping systems.
  • Specify criteria for and select piping specialty items.
  • Knowledge of manual valve sizing, use and application.
  • Identification of need, application and specification of safety valves and devices to maintain the mechanical integrity of process/utility systems.
  • Identification of need, application and specification of steam traps and liquid drainers.
  • Estimating mechanical/piping construction quantities from conceptual documents.
  • Knowledge of other disciplines deliverable development to ensure coordination of design efforts.
  • Knowledge and understanding of schedule constraints and information requirements for the production of all mechanical deliverables.
  • Ability to accurately estimate completion of assigned tasks.
  • Ability to develop a man-hour budget and schedule for discipline scope of project.
  • Ability to determine construction material quantities.
  • Knowledge and ability to apply company engineering design standards.
  • Ability to lead a small team to deliver on commitments.
  • Proficient in the use of Microsoft Word, Excel and Outlook.
  • Working knowledge of Revit and Plant 3D. Not required but will be responsible for reviewing capabilities.
  • Excellent communication skills, both verbal and written.
  • Excellent presentation skills.
  • Virtual team skills and cross divisional relationships are developed, and able to provide interoffice execution leadership and support.

Physical Requirements:
  • Ability to sit, stand, or walk for long periods of time.

Hargrove Culture
We work to create an environment founded on trust, personal integrity, and a "team mentality" so that each person understands the value of their contributions both on a project and company-wide level. We know that each person on our team contributes to the success of our company by pairing expertise and passion to meet and exceed the needs of the clients we serve across the globe.
Our safety culture protects and promotes the well-being of every person who works with us and every person touched by our work.
As a 100% Teammate owned company, we proudly offer a comprehensive benefits package including, paid holidays, personal paid time off, medical, dental, vision, life, and disability insurance, 401(k), and other benefits to eligible Teammates.
Equal Opportunity Employment Statement
Hargrove is an Equal Opportunity/Affirmative Action employer. We do not discriminate based upon race, color, national origin, religion, age, sex (including gender, sexual orientation, pregnancy, sexual identity, marital or family status), disability, military service or obligations, veteran status, or any other characteristic protected by law.
Hargrove is a drug-free workplace.
The selected candidate must be authorized to work in the United States.

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