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Downstream Process Development Jobs in Philadelphia, PA

Legend Biotech US

Scientist

Philadelphia, PA · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

This Scientist position will closely work with Molecular Biology, Downstream, Analytical and Technical development partners to ensure end-to-end process alignment, support comparability strategy and ...

Wood Plc

Senior Process Engineer

Philadelphia, PA · On-site +1

$104K - $135K/yr

A key contributor on process engineering design teams (upstream, downstream, utilities, fill ... Participating in project planning, cost development, and project scheduling * Maintaining effective ...

Morgan Properties

Senior Software Engineer

Conshohocken, PA · On-site

$120K - $159K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

... development and performance tuning, and production-grade React applications supporting data ... downstream processes. In addition, the role contributes to architectural design discussions ...

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Showing results 21-40

All JobsDownstream Process Development JobsDownstream Process Development Jobs in Philadelphia, PA

Downstream Process Development information

See Philadelphia, PA salary details

$19

$33

$49

How much do downstream process development jobs pay per hour?

As of Aug 18, 2026, the average hourly pay for downstream process development in Philadelphia, PA is $33.99, according to ZipRecruiter salary data. Most workers in this role earn between $27.88 and $41.73 per hour, depending on experience, location, and employer.

What is downstream process development?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What does someone in downstream process development do?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are the key skills and qualifications needed for downstream process development?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Philadelphia, PA as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $70,697 per year, or $34 per hour.

Senior Medical Tubing Extrusion Engineer

Martech Medical Products

Harleysville, PA • On-site

$100K - $138K/yr

Full-time

Posted 20 days ago

Job description


Senior Medical Tubing Extrusion Engineer
Onsite Position
Relocation assistance is not available

Join Our Team
Join a growing medical device manufacturing organization where your technical expertise will directly impact the development and production of innovative healthcare technologies.  As a Senior Medical Tubing Extrusion Engineer, you will serve as the technical leader for extrusion process development, validation, optimization, and commercialization activities.  This role offers the opportunity to work on complex medical tubing products, influence manufacturing strategy, mentor technical talent, and drive continuous improvement in a highly regulated environment.
Position Summary
The Senior Medical Tubing Extrusion Engineer serves as the subject matter expert for medical tubing extrusion processes and technologies.  This individual leads process development, validation, equipment and tooling improvements, and new product introduction activities while partnering closely with Manufacturing, Quality, Maintenance, Supply Chain, Project Management, and Commercial teams.
This role combines hands-on engineering expertise with technical leadership and offers the opportunity to influence both current operations and future manufacturing capabilities.
How You Will Contribute
  • Lead the development, optimization, validation, and sustainment of medical tubing extrusion processes to ensure product quality, efficiency, and compliance.
  • Design, develop, qualify, and maintain extrusion tooling, including dies, tips, mandrels, sizing fixtures, and downstream tooling.
  • Lead process and equipment validation activities, including IQ, OQ, PQ, process characterization, and capability studies.
  • Serve as the technical lead for extrusion-related New Product Introduction (NPI), commercialization, scale-up, and technology transfer projects.
  • Drive continuous improvement initiatives focused on yield improvement, process capability, throughput, cost reduction, and operational excellence.
  • Troubleshoot complex process, tooling, equipment, and product quality issues using structured problem-solving methodologies.
  • Conduct root cause investigations and implement effective corrective and preventive actions.
  • Develop and maintain engineering documentation, validation reports, SOPs, work instructions, and process standards.
  • Evaluate manufacturability, capacity requirements, and technical feasibility for new business opportunities and customer programs.
  • Mentor and train engineers, technicians, and manufacturing personnel to strengthen technical capabilities throughout the organization.
  • Support customer audits, supplier assessments, technical reviews, and regulatory inspections.
  • Evaluate and implement new materials, equipment, automation technologies, and manufacturing methods to expand organizational capabilities.
  • Lead cross-functional projects that support strategic manufacturing and business objectives.
Required Qualifications
  • Bachelor's degree in Mechanical Engineering, Polymer Engineering, Chemical Engineering, Manufacturing Engineering, Biomedical Engineering, or a related engineering discipline.
  • 7+ years of experience in extrusion engineering, polymer processing, medical device manufacturing, or a related manufacturing environment.
  • Demonstrated expertise in medical tubing extrusion process development, optimization, and troubleshooting.
  • Strong knowledge of thermoplastics, polymer behavior, and extrusion processing principles.
  • Experience designing and developing extrusion tooling, including dies, tips, mandrels, and sizing systems.
  • Experience leading process and equipment validations, including IQ, OQ, and PQ activities.
  • Strong understanding of Design of Experiments (DOE), Statistical Process Control (SPC), process characterization, and capability analysis.
  • Experience conducting root cause investigations and implementing corrective and preventive actions.
  • Strong technical writing, project management, and communication skills.
  • Demonstrated ability to lead technical projects and mentor engineers, technicians, and manufacturing personnel.
Preferred Qualifications
  • Experience in medical device manufacturing.
  • Knowledge of FDA Quality System Regulations (QSR), ISO 13485, Good Manufacturing Practices (GMP), Design Controls, Risk Management, and Change Control processes.
  • Experience with complex medical tubing products, including multilumen, tapered, reinforced, microbore, and specialty extrusions.
  • Experience supporting NPI, customer qualification, commercialization, and technology transfer activities.
  • Lean Six Sigma Green Belt or Black Belt certification.
  • Experience with SolidWorks or equivalent CAD software.
  • Experience supporting technical quoting and manufacturability assessments.
Work Authorization Requirement:  Applicants must be legally authorized to work in the United States on an unrestricted basis.  The Company does not sponsor employment visas or provide immigration-related sponsorship now or in the future.  Candidates requiring current or future sponsorship for employment authorization are not eligible for consideration.
 

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