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Director Dmpk Jobs (NOW HIRING)

Atavistik Bio

Senior Scientist, DMPK

Cambridge, MA

$130K - $150K/yr

Reporting to the Senior Director, DMPK, this individual will be responsible for the design, execution, reviewing and interpreting the non-clinical DMPK data. This work supports the progression of ...

Atavistik Bio

Senior Scientist, DMPK

Cambridge, MA · On-site

$130K - $150K/yr

Reporting to the Senior Director, DMPK, this individual will be responsible for the design, execution, reviewing and interpreting the non-clinical DMPK data. This work supports the progression of ...

Exelixis

Senior DMPK Director

Alameda, CA

The Senior DMPK Director has strong scientific, technical and leadership skills to develop and implement DMPK and modeling & simulation strategies to advance drug candidates from discovery to ...

Exelixis

Senior DMPK Director

Alameda, CA · On-site

The Senior DMPK Director has strong scientific, technical and leadership skills to develop and implement DMPK and modeling & simulation strategies to advance drug candidates from discovery to ...

Exelixis

Senior DMPK Director

Alameda, CA · On-site

The Senior DMPK Director has strong scientific, technical and leadership skills to develop and implement DMPK and modeling & simulation strategies to advance drug candidates from discovery to ...

Vrtx

Executive Director, Biotherapeutics DMPK

Boston, MA

$268K - $402K/yr

We are seeking an accomplished and strategic leader to serve as Executive Director, Biotherapeutics DMPK-Bioanalysis (DMPK-BA), to guide the DMPK-BA strategy for our rapidly growing Biotherapeutics ...

General Proximity

Head of DMPK

San Francisco, CA

We are seeking a first-rate DMPK expert to help us pioneer this uncharted frontier of drug ... direct modulation by the drug, the classical approach). Historically, the development of ...

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How much do director dmpk jobs pay per year?

As of Jun 13, 2026, the average yearly pay for director dmpk in the United States is $246,666.00, according to ZipRecruiter salary data. Most workers in this role earn between $230,000.00 and $261,000.00 per year, depending on experience, location, and employer.

What are the main responsibilities of a Director DMPK and how do they interact with other departments?

A Director DMPK is responsible for leading the strategy, design, and execution of drug metabolism and pharmacokinetic studies supporting drug discovery and development. This role involves collaborating closely with medicinal chemistry, toxicology, clinical pharmacology, and regulatory affairs teams to ensure the safe and efficient progression of drug candidates. Directors often oversee the interpretation of preclinical and clinical PK data, provide scientific input for regulatory submissions, and contribute to project milestone decisions. Regular interaction with both internal project teams and external partners is common, making cross-functional communication a key aspect of daily work. This collaborative environment enables Directors to make significant contributions to successful drug development pipelines.

What does a Director of DMPK do?

A Director of Drug Metabolism and Pharmacokinetics (DMPK) leads efforts to understand the absorption, distribution, metabolism, and excretion (ADME) of drug candidates. They design and oversee preclinical and clinical studies to optimize drug properties, ensuring efficacy and safety. This role involves collaborating with pharmacology, toxicology, and regulatory teams to drive drug development. Additionally, they interpret data, guide strategy, and contribute to regulatory submissions.

What are the key skills and qualifications needed to thrive in the Director Dmpk position, and why are they important?

To thrive as a Director DMPK (Drug Metabolism and Pharmacokinetics), you need advanced expertise in pharmacokinetics, drug metabolism, and bioanalytical methods, typically supported by a PhD in pharmaceutical sciences, chemistry, or a related field. Familiarity with regulatory guidelines, data analysis platforms like WinNonlin or Phoenix, and validated laboratory systems is crucial. Strong leadership, cross-functional collaboration, and effective communication skills help in guiding multidisciplinary teams and driving complex projects forward. These capabilities ensure the development and regulatory success of new drug candidates in a highly competitive and compliant environment.

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Director Dmpk jobs near you
Senior Scientist, Drug Metabolism & Pharmacokinetics (DMPK)

Senior Scientist, Drug Metabolism & Pharmacokinetics (DMPK)

Prime Medicine

Cambridge, MA

$107K - $137K/yr

Other

Posted 17 days ago

Job description

Position Overview

We are seeking a motivated and skilled Senior Scientist to join the Nonclinical Development group, contributing to the DMPK function in support of exploratory and IND-enabling programs across Prime Medicine's pipeline. Reporting to the Associate Director, DMPK/Bioanalytical Sciences, this individual will independently analyze and interpret datasets from in vivo studies, contribute to nonclinical regulatory documents, and work cross-functionally with pharmacology, translational biology and external CROs, to ensure high-quality DMPK data packages are delivered to support program timelines. The ideal candidate has a strong foundation in in vivo pharmacokinetics for RNA therapeutics and/or LNP-based delivery systems, thrives in a fast-paced and matrixed organization, and possesses the flexibility and positive attitude needed to make meaningful contributions to the Nonclinical Development team.

Primary Responsibilities
  • Analyze and interpret PK study data from exploratory and IND-enabling in vivo
  • Perform non-compartmental analysis (NCA) using Phoenix WinNonlin to derive key PK parameters (Cmax, AUC, T, Vd, CL).
  • Leverage expertise in DMPK to provide recommendations for in vivo study designs in collaboration with pharmacology and key stakeholders.
  • Perform bioanalytical assay development (30%) and collaborate with bioanalytical scientists to trouble-shoot challenges during method development to ensure quantitative methods for key analytes (LNP lipid components, mRNA, pegRNA, PD biomarkers) meet regulatory expectations and data quality standards..
  • Contribute to nonclinical regulatory documents including pharmacokinetics summaries and nonclinical study reports under the guidance of senior stakeholders in Nonclinical Development.
  • Maintain thorough records in the electronic laboratory notebook (ELN); prepare clear data summaries, presentations, and technical memos for program team and governance meetings.
Qualifications

Minimum Qualifications

  • D. in pharmacokinetics, pharmaceutical sciences, pharmacology, biochemistry, or a related discipline.
  • 6+ years of cumulative experience. Industry experience (biotech or pharmaceutical) with direct responsibility for in vivo DMPK study design, execution, and interpretation is required; postdoctoral training in a DMPK or translational pharmacology setting is strongly preferred
  • Demonstrated experience with in vivo PK studies in preclinical models and proficiency in NCA using Phoenix WinNonlin or equivalent software.
  • Familiarity with regulatory expectations for nonclinical DMPK assessments and bioanalytical assay development.
  • Demonstrated ability to coordinate with external CROs, including scientific guidance, protocol development, and data review..
  • Strong written and verbal communication skills; ability to present complex DMPK data clearly to multidisciplinary audiences.
  • Highly self-motivated, collaborative, and organized, with the ability to manage multiple priorities independently in a fast-paced matrix environment.

Preferred Qualifications

  • Familiarity with PK/PD modeling concepts; experience with Phoenix WinNonlin modeling modules a plus.
  • Experience with LNP-based delivery systems and/or RNA therapeutics (mRNA, siRNA, ASO, sgRNA or related modalities).
  • Experience with exploratory DMPK studies, evaluating new delivery vehicles and evaluation of biodistribution using in vivo
  • Familiarity with bioanalytical platforms supporting DMPK studies, including LC-MS/MS, RT-qPCR/ddPCR, ELISA/MSD.
  • Ability and excitement to contribute to the development and success of the Nonclinical Development team.

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